1-(3-Chloro-2-fluorophenyl)-N-methylmethanamine hydrochloride | 1951438-93-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3-Chloro-2-fluorophenyl)-N-methylmethanamine hydrochloride
• 英文别名: 1-(3-chloro-2-fluorophenyl)-N-methylmethanamine;hydrochloride
• CAS: 1951438-93-9
• 化学式: C8H10Cl2FN
• 分子量: 210.07
• InChiKey: UUSZDAKEQMOQNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.62
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Piperazine derivatives as tachykinin antagonists
  申请人：——

  公开号：US20040157858A1

  公开（公告）日：2004-08-12

  The present invention relates to piperazine derivatives of formula (I) wherein R and R 1 represent independently halogen or C 1-4 alkyl; R 2 is hydrogen or C 1-4 alkyl; n and m are independently 1 or 2 and pharmaceutically acceptable salts and solvates thereof, to process for their preparation, to pharmaceutical compositions containing them and to their medical use. 1

  本发明涉及式（I）的哌嗪衍生物，其中R和R1分别代表卤素或C1-4烷基；R2为氢或C1-4烷基；n和m分别独立为1或2，并且其药学上可接受的盐和溶剂化合物，以及制备它们的过程，包含它们的制药组合物和它们的医药用途。
• PIPERAZINE DERIVATIVES AS TACHYKININ ANTAGONISTS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1377560A1

  公开（公告）日：2004-01-07
• [EN] PIPERAZINE DERIVATIVES AS TACHYKININ ANTAGONISTS<br/>[FR] DERIVES PIPERAZINES COMME ANTAGONISTES DES TACHYKININES
  申请人：GLAXO GROUP LTD

  公开号：WO2002081461A1

  公开（公告）日：2002-10-17

  The present invention relates to piperazine derivatives of formula (I) wherein R and R1 represent independently halogen or C1-4 alkyl; R2 is hydrogen or C1-4 alkyl; n and m are independently 1 or 2 and pharmaceutically acceptable salts and solvates thereof, to process for their preparation, to pharmaceutical compositions containing them and to their medical use.