(3S)-1-[(p-nitrobenzyloxy)2-thiophenylacetyl]-3-(acetylamino)azetidin-2-one | 253445-86-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (3S)-1-[(p-nitrobenzyloxy)2-thiophenylacetyl]-3-(acetylamino)azetidin-2-one
• 英文别名: (4-nitrophenyl)methyl 2-[(3S)-3-acetamido-2-oxoazetidin-1-yl]-2-phenylsulfanylacetate
• CAS: 253445-86-2
• 化学式: C₂₀H₁₉N₃O₆S
• 分子量: 429.453
• InChiKey: BVVMUOLRSQUEAA-KKFHFHRHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  147
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (3S)-1-[(p-nitrobenzyloxy)2-thiophenylacetyl]-3-(acetylamino)azetidin-2-one 以 phosphate buffer 、 乙腈 为溶剂， 生成 ((S)-3-Acetylamino-2-oxo-azetidin-1-yl)-phenylsulfanyl-acetic acid
  参考文献：
  名称：

  Synthesis, reactivity and biochemical evaluation of 1,3-substituted azetidin-2-ones as enzyme inhibitors

  摘要：

  A series of monocyclic azetidinones were prepared, bearing, at position C-3, an acetylamino or a bromo substituent, at position N-1, a carboxymethyl group protected as p-nitrobenzyl ester (PNB) and alpha-functionalized with a potential leaving group (LG). These structures were designed as potential suicide-inhibitors of enzymes containing a serine nucleophile in their active site. The beta-lactam ring of these molecules was found to be stable in phosphate buffer (pH 7.5), but the PNB ester was rapidly cleaved. This constitutes a practical method of in situ deprotection. Depending on the nature of the LG group on the carboxymethyl chain, substitution of this group (LG = F) or decarboxylation (LG = SO2Ph) was observed under hydrolytic conditions. The 1,3-disubstituted azetidinones were inactive against beta-lactamases of classes A, B, C, and D. Three compounds behaved as weak reversible inhibitors of porcine pancreatic elastase (PPE). (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00819-4
• 作为产物：
  描述：

  乙酸酐 、 ((S)-3-Amino-2-oxo-azetidin-1-yl)-phenylsulfanyl-acetic acid 4-nitro-benzyl ester; compound with trifluoro-acetic acid 在 potassium carbonate 作用下， 以 水 、 乙腈 为溶剂， 反应 0.5h， 以74%的产率得到(3S)-1-[(p-nitrobenzyloxy)2-thiophenylacetyl]-3-(acetylamino)azetidin-2-one
  参考文献：
  名称：

  Synthesis, reactivity and biochemical evaluation of 1,3-substituted azetidin-2-ones as enzyme inhibitors

  摘要：

  A series of monocyclic azetidinones were prepared, bearing, at position C-3, an acetylamino or a bromo substituent, at position N-1, a carboxymethyl group protected as p-nitrobenzyl ester (PNB) and alpha-functionalized with a potential leaving group (LG). These structures were designed as potential suicide-inhibitors of enzymes containing a serine nucleophile in their active site. The beta-lactam ring of these molecules was found to be stable in phosphate buffer (pH 7.5), but the PNB ester was rapidly cleaved. This constitutes a practical method of in situ deprotection. Depending on the nature of the LG group on the carboxymethyl chain, substitution of this group (LG = F) or decarboxylation (LG = SO2Ph) was observed under hydrolytic conditions. The 1,3-disubstituted azetidinones were inactive against beta-lactamases of classes A, B, C, and D. Three compounds behaved as weak reversible inhibitors of porcine pancreatic elastase (PPE). (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00819-4

文献信息

• Synthesis, reactivity and biochemical evaluation of 1,3-substituted azetidin-2-ones as enzyme inhibitors
  作者：Cécile Beauve、Michèle Bouchet、Roland Touillaux、Jacques Fastrez、Jacqueline Marchand-Brynaert

  DOI：10.1016/s0040-4020(99)00819-4

  日期：1999.11

  A series of monocyclic azetidinones were prepared, bearing, at position C-3, an acetylamino or a bromo substituent, at position N-1, a carboxymethyl group protected as p-nitrobenzyl ester (PNB) and alpha-functionalized with a potential leaving group (LG). These structures were designed as potential suicide-inhibitors of enzymes containing a serine nucleophile in their active site. The beta-lactam ring of these molecules was found to be stable in phosphate buffer (pH 7.5), but the PNB ester was rapidly cleaved. This constitutes a practical method of in situ deprotection. Depending on the nature of the LG group on the carboxymethyl chain, substitution of this group (LG = F) or decarboxylation (LG = SO2Ph) was observed under hydrolytic conditions. The 1,3-disubstituted azetidinones were inactive against beta-lactamases of classes A, B, C, and D. Three compounds behaved as weak reversible inhibitors of porcine pancreatic elastase (PPE). (C) 1999 Elsevier Science Ltd. All rights reserved.