N-isopropyl-N-ethylbenzylamine | 68723-26-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-isopropyl-N-ethylbenzylamine
• 英文别名: ethyl-benzyl-isopropyl-amine；Aethyl-benzyl-isopropyl-amin；N-benzyl-N-ethylpropan-2-amine
• CAS: 68723-26-2
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: LDISDPDZZUDKHE-UHFFFAOYSA-N

物化性质

• 沸点：
  212-215 °C
• 密度：
  0.904±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-isopropyl-N-ethylbenzylamine 在 碘 、 sodium carbonate 作用下， 以 氯仿 为溶剂， 反应 24.0h， 以41%的产率得到N-乙基苄胺
  参考文献：
  名称：

  Transformation of N,N-diisopropylarylmethylamines into N-isopropylarylmethylamines with molecular iodine

  摘要：

  N,N-Diisopropylarylmethylamines were smoothly converted into the corresponding N-isopropylaryl-methylamines by the reaction with molecular iodine in the presence of Na2CO3 in chloroform at 60 degrees C. Other related tertiary amines were also transformed into the corresponding secondary amines by the reaction with molecular iodine under the same reaction conditions. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.10.044
• 作为产物：
  描述：

  2-碘代丙烷 、 N-乙基苄胺 在 氢氧化钾 作用下， 生成 N-isopropyl-N-ethylbenzylamine
  参考文献：
  名称：

  Wedekind; Ney, Chemische Berichte, 1912, vol. 45, p. 1306

  摘要：

  DOI：

文献信息

• THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF
  申请人：GENENTECH, INC.

  公开号：US20180105504A1

  公开（公告）日：2018-04-19

  The invention provides a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein the variables X, Y 1 -Y 5 , R 1 , R 2 , R 3 , R 4 , and Het have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

  本发明提供了一种式I化合物：或其药学上可接受的盐，其中变量X、Y1-Y5、R1、R2、R3、R4和Het的含义如本文所述，以及含有此类化合物的组合物和使用此类化合物及组合物的方法。
• BIARYL AMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
  申请人：Katayama Seiji

  公开号：US20130116227A1

  公开（公告）日：2013-05-09

  Disclosed is a novel biaryl amide derivative represented by formula (1) and having an affinity for the aldosterone receptor; also disclosed is a pharmaceutically acceptable salt thereof. (In the formula, A is any of the groups represented by formula (a); L is —CONH—, etc.; R 1 is a substitutable aminosulfonyl group, etc.; R 2 is a hydrogen atom, etc.; R 3 is a hydrogen atom, etc.; R 4 is a hydrogen atom, a halogen atom, hydroxy group, a substitutable amino group, a substitutable C 1-6 alkoxy group, a substitutable 4- to 7-membered cyclic amino group, etc.; R 5a , R 5b and R 5c are each independently hydrogen atoms, etc.; R 6 is a halogen atom, a cyano group, etc.; R 7 and R 8 are each independently a hydrogen atom, etc.; and m is an integer such as 0.)

  揭示了一种表示为公式（1）的新型联苯酰胺衍生物，具有与醛固酮受体的亲和力；还揭示了其药用可接受的盐。（在该公式中，A是由公式（a）表示的任何基团之一；L是—CONH—等；R1是可替代的氨基磺酰基等；R2是氢原子等；R3是氢原子等；R4是氢原子、卤原子、羟基、可替代的氨基基团、可替代的C1-6烷氧基、可替代的4-到7-成员环氨基基团等；R5a、R5b和R5c各自独立地是氢原子等；R6是卤原子、氰基等；R7和R8各自独立地是氢原子等；m是整数，例如0。）
• 4-Squarylpiperazine Derivatives as Antiviral Agents
  申请人：Bachand Carol

  公开号：US20070249624A1

  公开（公告）日：2007-10-25

  This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with 4-squarylpiperazine derivatives that possess unique antiviral activity. More particularly, the present disclosure relates to compounds useful for the treatment of HIV and AIDS.

  本公开提供具有药物和生物影响特性的化合物，它们的药物组合物和使用方法。具体而言，该公开涉及具有独特抗病毒活性的4-四氢喹啉基哌嗪衍生物。更具体地说，本公开涉及用于治疗艾滋病毒和艾滋病的化合物。
• SUBSTITUTED AMINOINDANES AND ANALOGS THEREOF, AND THE PHARMACEUTICAL USE THEREOF
  申请人：Rackelmann Nils

  公开号：US20110201590A1

  公开（公告）日：2011-08-18

  The invention relates to substituted aminoindanes and analogs thereof of formula (I) and the pharmaceutical use thereof. Medicaments which comprise compounds of this type are suitable for the prevention or treatment of diverse disorders such as, for example, of respiratory disorders, cystic fibrosis disorders, acute or chronic renal disorders or bowel disorders.

  该发明涉及公式（I）的替代氨基茚和类似物及其药用。包含这类化合物的药物适用于预防或治疗各种疾病，例如呼吸系统疾病、囊性纤维化疾病、急性或慢性肾脏疾病或肠道疾病。
• COMPOUNDS USEFUL AS INHIBITORS OF HELIOS PROTEIN
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20210147383A1

  公开（公告）日：2021-05-20

  Disclosed are compounds of Formula (I): or a salt thereof, wherein: Z is CR 6 R 6 or C═O; Ring A is: and R 1 , R 2 , R 3 , R 4 , R 5 , m, and n are defined herein. Also disclosed are methods of using such compounds to inhibit Helios protein, and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.

  公开的化合物为Formula (I)的化合物或其盐，其中：Z为CR6R6或C═O；环A为：而R1、R2、R3、R4、R5、m和n在此处有定义。还公开了使用这些化合物抑制Helios蛋白的方法，以及包含这些化合物的药物组合物。这些化合物在治疗病毒感染和增生性疾病（如癌症）方面非常有用。