3-(3-carboxypropyl)-5-phenylrhodanine | 81885-33-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-(3-carboxypropyl)-5-phenylrhodanine
• 英文别名: 4-(4-Oxo-5-phenyl-2-sulfanylidene-1,3-thiazolidin-3-yl)butanoic acid
• CAS: 81885-33-8
• 化学式: C₁₃H₁₃NO₃S₂
• 分子量: 295.383
• InChiKey: MZXHVWKDYDYJOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  sodium (RS)-α-bromophenylacetate 、 4-氨基丁酸 在 盐酸 、 二硫化碳 、 氨 作用下， 以 水 为溶剂， 生成 3-(3-carboxypropyl)-5-phenylrhodanine
  参考文献：
  名称：

  Rhodanine derivatives

  摘要：

  通用公式为：##STR1## 的罗丹啉衍生物对醛糖还原酶具有强烈的抑制活性，并可用于预防和治疗神经紊乱，如神经痛、视网膜病变、糖尿病性白内障以及肾脏紊乱，如肾小管肾病。

  公开号：

  US04446143A1

文献信息

• Rhodanine derivatives, a process for their preparation, and aldose reductase inhibitors containing such derivatives
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP0045165A1

  公开（公告）日：1982-02-03

  Rhodanine derivatives, process for their preparation, and aldose reductase inhibitor containing such derivatives. A rhodanine derivative of the general formula: is disclosed wherein R' represents a hydrogen atom, an alkyl group of 1-12 carbon atoms, an aralkyl group of 7-13 carbon atoms, a cycloalkyl group of 4-7 carbon atoms which is unsubstituted or substituted by at least one alkyl group of 1-4 carbon atoms, or a phenyl group which is unsubstituted or substituted by at least one halogen atom, trifluoromethyl group, phenyl group, nitro group, hydroxyl group, carboxyl group, amino group which may be substituted by an alkyl group of 1-4 carbon atoms, or alkyl, alkoxy or alkylthio group of 1-4 carbon atoms; R2 and R3, which may be the same or different, each represents a hydrogen atom, an alkyl group of 1-4 carbon atoms, or a phenyl group which is unsubstituted or substituted by at least one halogen atom, trifluoromethyl group, phenyl group, nitro group, hydroxyl group, carboxyl group, amino group which may be substituted by an alkyl group of 1-4 carbon atoms, or alkyl, alkoxy or alkylthio group of 1-4 carbon atoms; R4 represents an alkyl group of 1-4 carbon atoms, a cycloalkyl group of 4-7 carbon atoms which is unsubstituted or substituted by at least one alkyl group of 1-4 carbon atoms, a phenyl or benzyl group which is unsubstituted or substituted by at least one halogen atom, trifluoromethyl group, phenyl group, nitro group, hydroxyl group, carboxyl group, amino group which may be substituted by an alkyl group of 1-4 carbon atoms, or alkyl, alkoxy or alkylthio group of 1-4 carbon atoms, a naphthyl group, an anthracenyl group, or a heterocyclic group containing at least one of nitrogen, oxygen and sulfur atoms which is unsubstituted or substituted by at least one halogen atom, trifluoromethyl group, phenyl group, nitro group, hydroxyl group, carboxyl group, amino group which may be substituted by an alkyl group of 1-4 carbon atoms; or alkyl, alkoxy or alkylthio group of 1-4 carbon atoms; R5 represents a hydrogen atom, an alkyl group of 1-4 carbon atoms, a cycloalkyl group of 4-7 carbon atoms which is unsubstituted or substituted by at least one alkyl group of 1-4 carbon atoms, a phenyl or benzyl group which is unsubstituted or substituted by at least one halogen atom, trifluoromethyl group, phenyl group, nitro group, hydroxyl group, carboxyl group, amino group which may be substituted by an alkyl group of 1-4 carbon atoms, or alkyl, alkoxy or alkylthio group of 1-4 carbon atoms, a naphthyl group, an anthracenyl group, or a heterocyclic group containing at least one of nitrogen, oxygen and sulfur atoms which is unsubstituted or substituted by at least one halogen atom, trifluoromethyl group, phenyl group, nitro group, hydroxyl group, carboxyl group, amino group which may be substituted by an alkyl group of 1-4 carbon atoms, or alkyl, alkoxy or alkylthio group of 1-4 carbon atoms, with the proviso that when R5 represents a hydrogen atom, R4 does not represent an alkyl group of 1-4 carbon atoms; n is 0, 1 or 2; or when R' represents a hydrogen atom, a non-toxic salt of the acid. The derivatives of formula I and their non-toxic acid salts possess a strong inhibitory activity on aldose reductase, and are useful for the prevention and treatment of nerve disturbances such as neuralgia, retinopathy, diabetic cataract and renal disturbances such as tubular nephropathy.

  罗丹宁衍生物、其制备工艺以及含有此类衍生物的醛糖还原酶抑制剂。本发明公开了一种通式如下的罗丹宁衍生物： 其中 R'代表氢原子、1-12 个碳原子的烷基、7-13 个碳原子的芳烷基、未被取代或被至少一个 1-4 个碳原子的烷基取代的 4-7 个碳原子的环烷基、或未被取代或被至少一个卤原子、三氟甲基、苯基、硝基、羟基、羧基、可被 1-4 个碳原子的烷基或 1-4 个碳原子的烷基、烷氧基或烷硫基取代的苯基；R2 和 R3（可以相同或不同）分别代表氢原子、1-4 个碳原子的烷基或未被取代或被至少一个卤素原子、三氟甲基、苯基、硝基、羟基、羧基、可被 1-4 个碳原子的烷基或 1-4 个碳原子的烷基、烷氧基或烷硫基取代的苯基；R4 代表 1-4 个碳原子的烷基、未被取代或被至少一个 1-4 个碳原子的烷基取代的 4-7 个碳原子的环烷基、未被取代或被至少一个卤原子取代的苯基或苄基、三氟甲基、苯基、硝基、羟基、羧基、可被 1-4 个碳原子的烷基取代的氨基、或 1-4 个碳原子的烷基、烷氧基或烷硫基、萘基、蒽基、或含有至少一个氮、氧和硫原子的杂环基团，该杂环基团未被取代或被至少一个卤素原子、三氟甲基、苯基、硝基、羟基、羧基、可被 1-4 个碳原子的烷基取代的氨基取代；或 1-4 个碳原子的烷基、烷氧基或烷硫基；R5 代表氢原子、1-4 个碳原子的烷基、未被取代或被至少一个 1-4 个碳原子的烷基取代的 4-7 个碳原子的环烷基、未被取代或被至少一个卤素原子取代的苯基或苄基、三氟甲基、苯基、硝基、羟基、羧基、可被 1-4 个碳原子的烷基或 1-4 个碳原子的烷基、烷氧基或烷硫基取代的氨基、萘基、蒽基，或含有至少一个氮、氧和硫原子的杂环基团，该杂环基团未被取代或被至少一个卤素原子、三氟甲基、苯基、硝基、羟基、羧基、可被 1-4 个碳原子的烷基或 1-4 个碳原子的烷基、烷氧基或烷硫基取代，但当 R5 代表氢原子时，R4 不代表 1-4 个碳原子的烷基；n 为 0、1 或 2；或当 R' 代表氢原子时，为该酸的无毒盐。 式 I 的衍生物及其无毒酸盐对醛糖还原酶具有很强的抑制活性，可用于预防和治疗神经紊乱，如神经痛、视网膜病变、糖尿病性白内障和肾功能紊乱，如肾小管肾病。
• US4446143A
  申请人：——

  公开号：US4446143A

  公开（公告）日：1984-05-01