2-{[(cholesteryloxy)carbonyl]amino}ethyl methacrylate | 115748-23-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 2-{[(cholesteryloxy)carbonyl]amino}ethyl methacrylate
• 英文别名: cholesteryl N-(2-methacryloyloxyethyl)；2-[[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxycarbonylamino]ethyl 2-methylprop-2-enoate
• CAS: 115748-23-7
• 化学式: C₃₄H₅₅NO₄
• 分子量: 541.815
• InChiKey: OJKKWLOQQJTACH-NPIGIBJLSA-N

物化性质

• 沸点：
  622.8±44.0 °C(Predicted)
• 密度：
  1.05±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.8
• 重原子数：
  39
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  甲基丙烯酸异氰基乙酯 、 胆固醇 在 二月桂酸二丁基锡 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以95%的产率得到2-{[(cholesteryloxy)carbonyl]amino}ethyl methacrylate
  参考文献：
  名称：

  牙科复合应用液晶聚氨酯甲基丙烯酸酯的合成及性能

  摘要：

  合成了三种新型液晶甲基丙烯酸酯，并表征为在光固化牙科树脂基复合材料中作为共聚单体进行测试。选定的配方由甲基丙烯酸烷基铵或胆甾醇型氨基甲酸酯和2,2-双[4-（2-羟基-3-甲基丙烯酰氧基丙基）苯基]丙烷（BisGMA）或经甲基丙烯酸氨基甲酸酯基团改性的BisGMA衍生物组成，并进一步用三乙二醇二甲基丙烯酸酯稀释（TEGDMA），并用70％的填料（硅酸锆纳米粉，硅烷化填料）增强。这项研究解决了LC单体结构，光聚合速率（通过差示扫描光度法）和牙科树脂复合材料的特定性能（体积收缩率，吸水率，水溶性和疏水性）之间的关系。通过差示扫描量热法和偏光显微镜对LC性能的研究表明，LC中间相对室温（阳离子单体）或40°C（甲基丙烯酸胆固醇酯）稳定。发现与BisGMA / TEGDMA结合使用的LC氨基甲酸酯甲基丙烯酸酯的聚合速率为（0.122-0.136 s-1）高于单独的介晶单体（0.085-0.107 s

  DOI：

  10.1002/pola.24693

文献信息

• Effect of Hydrophobic Interactions on Properties and Stability of DNA−Polyelectrolyte Complexes
  作者：Sergey K. Filippov、Čestmír Koňák、Pavla Kopečková、Larisa Starovoytova、Milena Špírková、Petr Štěpánek

  DOI：10.1021/la9036716

  日期：2010.4.6

  Polyplexes are polyelectrolyte complexes of DNA and polycations, designed for potential gene delivery. We investigated the properties of new polyplexes formed from cholesterol-modified polycations and DNA. Three complexes were tested; their cholesterol contents were 1.4, 6.3, and 8.7 mol %. UV spectroscopy and fluorescence assay using ethidium bromide proved the formation of polyplexes. The kinetics of turbidity of polyplexes solutions in physiological solution showed that the colloid stability of polyplexes increases with increasing content of cholesterol in polycations. Dynamic, static, and electrophoretic light scattering, small-angle X-ray scattering, and atomic force microscopy were used for characterization of polyplexes. The observed hydrodynamic radii of polyplexes were in the range of 30-60 nm; they were related to the polycation/DNA ratio and hydrophobicity of the used polycations (the cholesterol content). The properties of polyplex particles depend, in addition to polycation structure, on the rate of polycation addition to DNA solutions.