4-methoxymethylsalicylic acid | 185743-02-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methoxymethylsalicylic acid
• 英文别名: 2-Hydroxy-4-(methoxymethyl)benzoic acid
• CAS: 185743-02-6
• 化学式: C₉H₁₀O₄
• 分子量: 182.176
• InChiKey: GRAPGABDJXOQFI-UHFFFAOYSA-N

物化性质

• 沸点：
  323.3±37.0 °C(Predicted)
• 密度：
  1.305±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-methoxymethylsalicylic acid 在 potassium hydroxide 、 sodium hydroxide 作用下， 以 吡啶 、 水 为溶剂， 反应 1.0h， 生成 7-羟基黄酮
  参考文献：
  名称：

  修饰的Baker-Venkataraman转化法新合成乙酰乙酸甘油酯，油绿酚，薯in皂素，曲霉素和其他羟基化黄酮

  摘要：

  Baker-Venkataraman（BV）重排是合成黄酮的选择方法。BV的主要局限性在于它需要对羟基进行广泛的保护和脱保护，这会使该过程冗长且麻烦。在本研究中，使用简单的保护基团和容易获得的原料开发了一种三步有效的方法。描述了新的合成醋氨蝶呤，瓜油酚，薯met皂素，甘油三酸酯和其他羟基黄酮。

  DOI：

  10.2174/1570178611999140206115633

文献信息

• Benzoyl piperidines/pyrrolidines for enhancing synaptic response
  申请人：Cortex Pharmaceuticals, Inc.

  公开号：US05650409A1

  公开（公告）日：1997-07-22

  Benzoyl piperidines and pyrrolidines and compounds of related structure are disclosed for use in enhancing synaptic responses mediated by AMPA receptors. The compounds are effective in the treatment of subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number or strength of excitatory synapses or in the number of AMPA receptors. The compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors, for improving the performance of subjects with memory deficiencies, for treating depression, alcoholism and schizophrenia, and for improving memory encoding.

  本发明揭示了苯甲酰哌啶和吡咯烷以及相关结构的化合物，用于增强由AMPA受体介导的突触反应。这些化合物对于治疗因兴奋性突触数量或强度不足或AMPA受体数量不足而导致神经或智力功能受损的受试者具有有效性。这些化合物还可用于治疗非受损受试者，以增强依赖利用AMPA受体的脑网络的感觉运动和认知任务表现，用于改善记忆不足的受试者表现，用于治疗抑郁症、酒精中毒和精神分裂症，以及用于改善记忆编码。
• 2-ALKYLOXY BENZENE FORMYL ARYLAMINE COMPOUND AND PHARMACEUTICAL USE THEREOF
  申请人：Fudan University

  公开号：EP3196191A1

  公开（公告）日：2017-07-26

  The present invention relates to 2-alkoxy benzene formyl arylamine compounds as scheme I , in which the R, G, X, Y, Z are consistent with the detailed description in the patent claim. The compounds can act as sphingomyelin synthase (SMS) inhibitors to treat diseases caused by abnormal increasing of sphingomyelin(SM). This invention also includes compounds as scheme I , their pharmaceutically acceptable salts, pharmaceutical compositions as the active ingredients, and their application in drugs which can prevent and cure diseases caused by SM level abnormal increase. These diseases include atherosclerosis, fatty liver, obesity, type II diabetes, and other metabolic syndromes.

  本发明涉及如方案 I 所示的 2-烷氧基苯甲酰芳胺化合物，其中 R、G、X、Y、Z 与专利权利要求书中的详细描述一致。这些化合物可作为鞘磷脂合成酶（SMS）抑制剂，用于治疗因鞘磷脂（SM）异常增加而引起的疾病。本发明还包括作为活性成分的方案I化合物、它们的药学上可接受的盐、药物组合物，以及它们在药物中的应用，这些药物可以预防和治疗由SM水平异常升高引起的疾病。这些疾病包括动脉粥样硬化、脂肪肝、肥胖症、II 型糖尿病和其他代谢综合征。
• 2-alkyloxy benzene formyl arylamine compound and pharmaceutical use thereof
  申请人：FUDAN UNIVERSITY

  公开号：US10196359B2

  公开（公告）日：2019-02-05

  2-alkoxy benzene formyl arylamine compounds and their pharmaceutical salts are disclosed. The compounds can act as sphingomyelin synthase (SMS) inhibitors to treat diseases caused by abnormal increasing of sphingomyelin (SM). The pharmaceutically acceptable salts and pharmaceutical compositions of the compounds are used as active ingredients in drugs which can prevent and cure diseases caused by SM level abnormal increase. These diseases include atherosclerosis, fatty liver, obesity, type diabetes, and other metabolic syndromes.

  本研究公开了 2-烷氧基苯甲酰芳胺化合物及其药物盐。这些化合物可作为鞘磷脂合成酶（SMS）抑制剂，治疗因鞘磷脂（SM）异常增加而引起的疾病。这些化合物的药学上可接受的盐和药物组合物可作为药物的活性成分，用于预防和治疗由鞘磷脂水平异常升高引起的疾病。这些疾病包括动脉粥样硬化、脂肪肝、肥胖症、糖尿病和其他代谢综合征。
• BENZOYL PIPERIDINES/PYRROLIDINES FOR ENHANCING SYNAPTIC RESPONSE
  申请人：CORTEX PHARMACEUTICALS, INC.

  公开号：EP0839134A1

  公开（公告）日：1998-05-06
• SALICYLIC ACID DERIVATIVES WITH FLUOROPHORES AND METHOD OF MAKING AND USING THE SAME
  申请人：HUANG Sheng-Tung

  公开号：US20120252047A1

  公开（公告）日：2012-10-04

  A latent fluorophore is derived from salicylic acid, and containing a fluorogenic group and a moiety represented by formula I wherein the fluorogenic group is directly linked to the moiety of formula I or indirectly linked thereto via a linkage structure. In addition, a method of preparing a latent fluorophore, a method of using the same and a kit containing the same are also introduced.