6-(1H-imidazol-1-yl)-2-pyridinamine | 1314355-97-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-(1H-imidazol-1-yl)-2-pyridinamine
• 英文别名: 6-(1H-Imidazol-1-yl)pyridin-2-amine；6-imidazol-1-ylpyridin-2-amine
• CAS: 1314355-97-9
• 化学式: C₈H₈N₄
• 分子量: 160.178
• InChiKey: PHACTKOEQFYCPA-UHFFFAOYSA-N

物化性质

• 沸点：
  400.9±30.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56.7
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  咪唑 、 2-氨基-6-溴吡啶 在 potassium carbonate 作用下， 以 neat (no solvent) 为溶剂， 反应 18.0h， 以80%的产率得到6-(1H-imidazol-1-yl)-2-pyridinamine
  参考文献：
  名称：

  Facile and scalable preparation of 2-imidazolylpyridines

  摘要：

  A novel method for the synthesis of 2-imidazolylpyridines is presented. The reaction of 2-halopyridines, potassium carbonate, and imidazole at high temperatures under inert gas atmosphere leads exclusively to the formation of 2-imidazolylpyridines in high yields. The synthesis is scalable, comparatively inexpensive, and the products are easily isolable. (c) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.04.060

文献信息

• PEPTIDE DEFORMYLASE INHIBITORS
  申请人：Glaxosmithkline Intellectual Property (No. 2) Limited

  公开号：EP2684039A2

  公开（公告）日：2014-01-15
• [EN] PEPTIDE DEFORMYLASE INHIBITORS<br/>[FR] INHIBITEURS DE LA PEPTIDE DÉFORMYLASE
  申请人：GLAXOSMITHKLINE LLC

  公开号：WO2012122450A2

  公开（公告）日：2012-09-13

  The present invention relates to a compound of Formula (I), or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.
• Facile and scalable preparation of 2-imidazolylpyridines
  作者：Andreas Raba、Markus R. Anneser、Dominik Jantke、Mirza Cokoja、Wolfgang A. Herrmann、Fritz E. Kühn

  DOI：10.1016/j.tetlet.2013.04.060

  日期：2013.6

  A novel method for the synthesis of 2-imidazolylpyridines is presented. The reaction of 2-halopyridines, potassium carbonate, and imidazole at high temperatures under inert gas atmosphere leads exclusively to the formation of 2-imidazolylpyridines in high yields. The synthesis is scalable, comparatively inexpensive, and the products are easily isolable. (c) 2013 Elsevier Ltd. All rights reserved.