N'-pentanoylbenzohydrazide | 904041-53-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-pentanoylbenzohydrazide
• CAS: 904041-53-8
• 化学式: C₁₂H₁₆N₂O₂
• 分子量: 220.271
• InChiKey: ZONKQSVDTXKIAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N'-pentanoylbenzohydrazide 在 N,N-二异丙基乙胺 、 对甲苯磺酰氯 作用下， 以 乙腈 为溶剂， 生成 2-butyl-5-phenyl-1,3,4-oxadiazole
  参考文献：
  名称：

  Mild and convenient one-pot synthesis of 1,3,4-oxadiazoles

  摘要：

  A mild, general, convenient, and efficient one-pot synthesis of 2-phenyl-5-substituted-1,3,4-oxadiazoles is described. Both (hetero)aryl and alkyl carboxylic acids were efficiently condensed with benzohydrazide in the presence of TBTU to give diacylhydrazine intermediates. The latter underwent a smooth TsCl-mediated cyclodehydration reaction to afford 2-phenyl-5-substituted-1,3,4-oxadiazoles in good to very good yields. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.06.139
• 作为产物：
  描述：

  苯甲酰肼 、 正戊酸 在 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 生成 N'-pentanoylbenzohydrazide
  参考文献：
  名称：

  Mild and convenient one-pot synthesis of 1,3,4-oxadiazoles

  摘要：

  A mild, general, convenient, and efficient one-pot synthesis of 2-phenyl-5-substituted-1,3,4-oxadiazoles is described. Both (hetero)aryl and alkyl carboxylic acids were efficiently condensed with benzohydrazide in the presence of TBTU to give diacylhydrazine intermediates. The latter underwent a smooth TsCl-mediated cyclodehydration reaction to afford 2-phenyl-5-substituted-1,3,4-oxadiazoles in good to very good yields. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.06.139

文献信息

• Insecticidal N'-substituted-N-alkylcarbonyl-N'-acylhydrazines and N'-substituted -N-acyl-N'-alkylcarbonyl hydrazines
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0347216A2

  公开（公告）日：1989-12-20

  This invention concerns certain insecticidally active N′-substituted-N-alkylcarbonyl-N′-acylhydrazines or N′-substituted-N-acyl-N′-alkylcarbonylhydrazines and compositions containing such compounds.

  本发明涉及某些具有杀虫活性的 N′-取代-N-烷基羰基-N′-酰基肼或 N′-取代-N-酰基-N′-烷基羰基肼以及含有这类化合物的组合物。
• Mild and convenient one-pot synthesis of 1,3,4-oxadiazoles
  作者：Paolo Stabile、Alessandro Lamonica、Arianna Ribecai、Damiano Castoldi、Giuseppe Guercio、Ornella Curcuruto

  DOI：10.1016/j.tetlet.2010.06.139

  日期：2010.9

  A mild, general, convenient, and efficient one-pot synthesis of 2-phenyl-5-substituted-1,3,4-oxadiazoles is described. Both (hetero)aryl and alkyl carboxylic acids were efficiently condensed with benzohydrazide in the presence of TBTU to give diacylhydrazine intermediates. The latter underwent a smooth TsCl-mediated cyclodehydration reaction to afford 2-phenyl-5-substituted-1,3,4-oxadiazoles in good to very good yields. (C) 2010 Elsevier Ltd. All rights reserved.