1-(6-(3-(trifluoromethyl)phenyl)pyridin-2-yl)ethanone | 1227055-11-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(6-(3-(trifluoromethyl)phenyl)pyridin-2-yl)ethanone
• 英文别名: 1-[6-[3-(trifluoromethyl)phenyl]pyridin-2-yl]ethanone
• CAS: 1227055-11-9
• 化学式: C₁₄H₁₀F₃NO
• 分子量: 265.235
• InChiKey: FPKIPPVUORQOQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(6-(3-(trifluoromethyl)phenyl)pyridin-2-yl)ethanone 在 sodium hydride 、 肼 作用下， 以 四氢呋喃 、 乙二醇乙醚 、 乙醇 、 水 为溶剂， 反应 36.0h， 生成
  参考文献：
  名称：

  Efficient yellow OLEDs based on bis-tridentate iridium(III) complexes with two C∧N∧N-coordinating ligands

  摘要：

  Four bis-tridentate iridium(III) complexes with two different C boolean AND N boolean AND N-coordinating ligands have been synthesized and characterized. All complexes exhibited yellow/orange emission peaking at 580-604 nm with short lifetimes of 1.4-1.6 mu s and medium photoluminescence quantum yields (PLQYs) of 31%-53%. These complexes exhibit good thermal stability with decomposition temperature (T-d) exceeding 310 degrees C. The luminescence efficiency and thermal stability of iridium complexes were improved by the m-substituted CF3 groups. As a result, complex 2 exhibited the highest PLQYs of 0.53 and T-d of 348 degrees C. The OLEDs based on complex 2 showed good performances. The device at 2% doping concentration showed a maximum current efficiency of 36.4 cd A(-1), power efficiency of 29.1 lm W-1 and external quantum efficiency (EQE) of 14.4%. These results suggest that these complexes have potential for the application in high-efficiency OLEDs.

  DOI：

  10.1016/j.ica.2019.119168
• 作为产物：
  描述：

  间溴三氟甲苯 在 四(三苯基膦)钯 、 正丁基锂 、 potassium carbonate 作用下， 以 四氢呋喃 、 正己烷 、 水 为溶剂， 反应 28.5h， 生成 1-(6-(3-(trifluoromethyl)phenyl)pyridin-2-yl)ethanone
  参考文献：
  名称：

  2-PHENYL-6-AZOLYLPYRIDINE-BASED LIGAND AND GROUP VIII TRANSITION METAL COMPLEX

  摘要：

  一种基于2-苯基-6-氮杂吡啶的配体由以下公式（I）表示：其中，X代表氮或C—R10；R1、R2、R3、R4、R5、R6、R7、R8和R10独立地代表氢、卤素、氰基、氨基、可选择取代的芳基、可选择取代的杂环芳基、硫酸根、—COOH、烷氧基、羰基、C1-C10卤代烷基、C1-C12烷基、C2-C10烯基、C2-C10炔基、C3-C20环烷基、C3-C20环烯基、C1-C20杂环烷基或C1-C20杂环烯基；R9代表氢或碱金属。

  公开号：

  US20130018189A1

文献信息

• [EN] PYRIDINE, BICYCLIC PYRIDINE AND RELATED ANALOGS AS SIRTUIN MODULATORS<br/>[FR] PYRIDINE, PYRIDINE BICYCLIQUE ET ANALOGUES ASSOCIÉS EN TANT QUE MODULATEURS DE SIRTUINE
  申请人：SIRTRIS PHARMACEUTICALS INC

  公开号：WO2010056549A1

  公开（公告）日：2010-05-20

  The present invention provides novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders relating to aging or stress, diabetes, obesity, neurodegenerative disease, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorder that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. The compounds are of general formula (III) wherein R1, R2, R", X, Y, W, Z1 and Z2 are as defined in the specification.

  本发明提供了新颖的调节sirtuin的化合物以及其使用方法。这些调节sirtuin的化合物可用于延长细胞寿命，并用于治疗和/或预防与衰老或压力、糖尿病、肥胖、神经退行性疾病、心血管疾病、血液凝块障碍、炎症、癌症、潮红以及需要增加线粒体活性的疾病或疾病。还提供了包含sirtuin调节化合物与另一治疗剂组合的组合物。这些化合物的一般化学式为（III），其中R1、R2、R"、X、Y、W、Z1和Z2如规范中定义。
• PYRIDINE, BICYCLIC PYRIDINE AND RELATED ANALOGS AS SIRTUIN MODULATORS
  申请人：Narayan Radha

  公开号：US20110263564A1

  公开（公告）日：2011-10-27

  Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了一种新型的调节sirtuin的化合物及其使用方法。这些sirtuin调节化合物可用于延长细胞寿命，治疗和/或预防各种疾病和障碍，包括与衰老或压力相关的疾病或障碍、糖尿病、肥胖症、神经退行性疾病、心血管疾病、血液凝块障碍、炎症、癌症和/或潮红，以及需要增加线粒体活性的疾病或障碍。此外，还提供了包含sirtuin调节化合物与另一种治疗剂联合使用的组合物。
• US8580961B2
  申请人：——

  公开号：US8580961B2

  公开（公告）日：2013-11-12
• 2-PHENYL-6-AZOLYLPYRIDINE-BASED LIGAND AND GROUP VIII TRANSITION METAL COMPLEX
  申请人：Chi Yun

  公开号：US20130018189A1

  公开（公告）日：2013-01-17

  A 2-phenyl-6-azolylpyridine-based ligand is represented by the following formula (I): wherein, X represents nitrogen or C—R 10 ; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 10 independently represent hydrogen, halogen, a cyano group, an amino group, an optionally substituted aryl group, an optionally substituted heteroaryl group, sulfate, —COOH, an alkoxy group, a carbonyl group, a C 1 -C 10 haloalkyl group, a C 1 -C 12 alkyl group, a C 2 -C 10 alkenyl group, a C 2 -C 10 alkynyl group, a C 3 -C 20 cycloalkyl group, a C 3 -C 20 cycloalkenyl group, a C 1 -C 20 heterocycloalkyl group, or a C 1 -C 20 heterocycloalkenyl group; and R 9 represents hydrogen or alkali metal.

  一种基于2-苯基-6-氮杂吡啶的配体由以下公式（I）表示：其中，X代表氮或C—R10；R1、R2、R3、R4、R5、R6、R7、R8和R10独立地代表氢、卤素、氰基、氨基、可选择取代的芳基、可选择取代的杂环芳基、硫酸根、—COOH、烷氧基、羰基、C1-C10卤代烷基、C1-C12烷基、C2-C10烯基、C2-C10炔基、C3-C20环烷基、C3-C20环烯基、C1-C20杂环烷基或C1-C20杂环烯基；R9代表氢或碱金属。
• Efficient yellow OLEDs based on bis-tridentate iridium(III) complexes with two C∧N∧N-coordinating ligands
  作者：Yuan-Yuan Hu、Wei Luo、Yan Wang、Bi-Hai Tong、Man-Keung Fung、Qian-Feng Zhang

  DOI：10.1016/j.ica.2019.119168

  日期：2020.1

  Four bis-tridentate iridium(III) complexes with two different C boolean AND N boolean AND N-coordinating ligands have been synthesized and characterized. All complexes exhibited yellow/orange emission peaking at 580-604 nm with short lifetimes of 1.4-1.6 mu s and medium photoluminescence quantum yields (PLQYs) of 31%-53%. These complexes exhibit good thermal stability with decomposition temperature (T-d) exceeding 310 degrees C. The luminescence efficiency and thermal stability of iridium complexes were improved by the m-substituted CF3 groups. As a result, complex 2 exhibited the highest PLQYs of 0.53 and T-d of 348 degrees C. The OLEDs based on complex 2 showed good performances. The device at 2% doping concentration showed a maximum current efficiency of 36.4 cd A(-1), power efficiency of 29.1 lm W-1 and external quantum efficiency (EQE) of 14.4%. These results suggest that these complexes have potential for the application in high-efficiency OLEDs.