3-allyloxy-2-oxy-propylamine | 6967-44-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-allyloxy-2-oxy-propylamine
• 英文别名: 1-allyloxy-3-amino-propan-2-ol；3-allyloxy-2-oxypropylamine；1-(Allyloxy)-3-aminopropan-2-ol；1-amino-3-prop-2-enoxypropan-2-ol
• CAS: 6967-44-8
• 化学式: C₆H₁₃NO₂
• mdl: MFCD00047938
• 分子量: 131.175
• InChiKey: CBTJEAMLAOXIEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.666
• 拓扑面积：
  55.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-allyloxy-2-oxy-propylamine 在 platinum(0) 2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane complex 2,6-二叔丁基-4-甲基苯酚 、 糖精 作用下， 以 methylvinyl cyclosiloxane 、 甲苯 为溶剂， 反应 5.0h， 生成
  参考文献：
  名称：

  [EN] SILICONE (METH)ACRYLAMIDE MONOMER, POLYMER, OPHTHALMIC LENS, AND CONTACT LENS
  [FR] (MÉTH)ACRYLAMIDE DE SILICONE, MONOMÈRE, POLYMÈRE, LENTILLE OPHTALMIQUE ET LENTILLE DE CONTACT

  摘要：

  本发明涉及一种硅（甲基）丙烯酰胺单体，该硅（甲基）丙烯酰胺单体特别适用于隐形眼镜、人工晶状体、人工角膜等产品的使用。

  公开号：

  WO2011116206A1
• 作为产物：
  描述：

  potassium;N-(2-hydroxy-3-prop-2-enoxypropyl)sulfamate 在 盐酸 作用下， 以70.9%的产率得到3-allyloxy-2-oxy-propylamine
  参考文献：
  名称：

  氨基磺酸衍生物与环氧化物的反应

  摘要：

  二缩水甘油醚和烯丙基缩水甘油醚与氨基磺酸盐的反应，然后产物的酸水解得到相应的氨基醚。氨基磺酸与乙醇的醇解被建议作为温和消除磺基的方法。

  DOI：

  10.1007/bf02495401
• 作为试剂：
  描述：

  ammonium hydroxide 、 氨 、 烯丙基缩水甘油醚 在 ice 、 3-allyloxy-2-oxy-propylamine 、 liquid 作用下， 82.0 ℃ 、13.33 kPa 条件下， 反应 48.0h， 生成 3-allyloxy-2-oxy-propylamine
  参考文献：
  名称：

  (Meth)acrylamide monomers containing hydroxy and silicone functionalities

  摘要：

  本发明涉及式为：的（甲基）丙烯酰胺单体：其中R为H或CH3，R1选自具有1至8个碳原子的取代和未取代烷基，取代和未取代苯和甲苯基，以及R2、R3和R4分别选自具有1至8个碳原子的烷基，取代和未取代苯和甲苯基，以及—OSiR5R6R7，其中R5、R6和R7分别选自由1至4个碳原子的直链或支链烷基组成的群。还公开了由此制得的聚合物。

  公开号：

  US07396890B2

文献信息

• (METH)ACRYLAMIDE MONOMERS CONTAINING HYDROXY AND SILICONE FUNCTIONALITIES
  申请人：Zanini Diana

  公开号：US20070167592A1

  公开（公告）日：2007-07-19

  The present invention relates to (meth)acrylamide monomers of the formula: wherein R is H or CH 3 , R 1 is selected from H, substituted and unsubstituted alkyl groups having 1 to 8 carbon atoms, substituted and unsubstituted benzene and toluene groups and and R 2 , R 3 and R 4 are independently selected from alkyl groups having 1 to 8 carbon atoms, substituted and unsubstituted benzene and toluene groups, and —OSiR 5 R 6 R 7 wherein R 5 , R 6 and R 7 are independently selected from the group consisting of straight or branched alkyl groups having 1 to 4 carbon atoms. Polymers made therefrom are also disclosed.

  本发明涉及式子为（meth）acrylamide单体：其中R为H或CH3，R1选自具有1至8个碳原子的取代和未取代烷基，取代和未取代苯和甲苯基以及式子和R2，R3和R4分别选自具有1至8个碳原子的烷基，取代和未取代苯和甲苯基以及—OSiR5R6R7，其中R5，R6和R7分别选自直链或支链烷基组成的群。还公开了由此制得的聚合物。
• Methods and structures employing non-radioactive chemically-labeled polynucleotide probes
  申请人：ENZO BIOCHEM, INC.

  公开号：EP0117440A1

  公开（公告）日：1984-09-05

  Non-radioactive chemically-labeled polynucleotide probes, such as non-radioactive chemically-labeled, single- stranded DNA probes, are hybridized to fixed, denatured, single-stranded genetic material having a make-up complementary to said probes for determining the identification and/or presence of said genetic material. The non-radioactive chemical label on said probe is employed to elicit a response therefrom so as to determine the identity and/or presence of said genetic material. It is preferred that the non-radioactive chemical label attached to the probe have an enzyme attached thereto after hybridization, and that the presence of the enzyme attached to the chemically-labeled probe be elicited by spectro-photometric assay techniques.

  非放射性化学标记的多核苷酸探针，如非放射性化学标记的单链 DNA 探针，与固定的变性单链遗传物质杂交，该遗传物质的组成与所述探针互补，以确定所述遗传物质的识别和/或存在。所述探针上的非放射性化学标记用于引起探针的反应，以确定所述遗传物质的特征和/或存在。最好是探针上的非放射性化学标记在杂交后附有酶，并通过分光光度测定技术来激发附在化学标记探针上的酶的存在。
• Method and materials useful for the analysis and detection of genetic material
  申请人：ENZO BIOCHEM, INC.

  公开号：EP0124124A2

  公开（公告）日：1984-11-07

  in techniques for the analysis of genetic material, such as DNA and/or RNA, wherein the genetic material is denatured, fixed to a substrate and hybridized with a probe, superior results are obtainable when there is employed as the probe a chemically labeled probe which, preferably after hybridization, has added or attached thereto, such as to the chemical label or moiety of the probe, an enzyme component effective upon contact with a chromogen to produce an insoluble color precipitate or product. Techniques for the analysis of genetic material which are improved in sensitivity, definition, accuracy and/or speed, by employing a chemically labeled probe, include such well known techniques as «Southern» blot analysis, «Northern» blot analysis, «Western» blot analysis, colony hybridization, plaque lifts, cytoplasmic dot hybridization, in situ hybridization to cells and/or tissues and other such techniques.

  在分析遗传物质（如 DNA 和/或 RNA）的技术中，遗传物质被变性、固定在基质上并 与探针杂交，当探针采用化学标记的探针时，可获得较好的结果，该探针最好在杂交 后添加或附着（如在探针的化学标记或分子上）一种酶成分，该酶成分与发色剂接触 后可产生不溶性的彩色沉淀或产物。通过采用化学标记探针，在灵敏度、清晰度、准确性和/或速度方面都有所提高的遗传物质分析技术包括众所周知的 "Southern "印迹分析、"Northern "印迹分析、"Western "印迹分析、菌落杂交、斑块升降、细胞质点杂交、细胞和/或组织原位杂交等技术。
• Ribose- and 2-deoxyribose compounds
  申请人：YALE UNIVERSITY

  公开号：EP0329198A2

  公开（公告）日：1989-08-23

  The invention relates to ribose- and 2-deoxyribose compounds having the general formula The definitions of the compounds is given in the claims. Applications include detection and localization of poly­nucleotide sequences in chromosomes, fixed cells, tissue sections, and cell extracts. Specific applications include chromosomal karyotyping, clinical diagnosis of nucleic acid-­containing etiological agents, e.g. bacteria, viruses, or fungi, and diagnosis of genetic disorders.

  本发明涉及具有通式的核糖和 2-脱氧核糖化合物。 化合物的定义见权利要求。 其应用包括染色体、固定细胞、组织切片和细胞提取物中多核苷酸序列的检测和定位。具体应用包括染色体核型分析、含核酸病原体（如细菌、病毒或真菌）的临床诊断以及遗传疾病的诊断。
• Modified nucleic acids and their use
  申请人：BioChip Technologies GmbH

  公开号：EP1111069A1

  公开（公告）日：2001-06-27

  The invention relates to a process for the modification of double-stranded nucleic acids with groups that allow a covalent binding of these nucleic acids to surfaces on supports or other substrates. In a further embodiment, the invention relates to a modified nucleic acid obtainable according to the method or process just mentioned. In a further embodiment, the present invention relates to a support carrying a covalently bonded modified nucleic acid, especially a DNA or RNA, where the nucleic acid is bonded via one or more modified nucleosides to the surface of said support In a further embodiment, the invention relates to a method of manufacturing a support carrying a covalently bonded modified nucleic acid, especially a DNA or RNA, where the nucleic acid is bonded via one or more modified nudeosides to the surface of said support. Furthermore, the invention relates to a matrix that may be gel-like and that is obtainable by cross-linking of a modified nucleid acid according to the invention with a cross-linker. The invention also relates to a method of manufacture of such a matrix. The invention also relates to a kit employing a support or matrix according to the invention, especially for detection or purification of nucleic acids, or nucleic acid binding (e.g. regulatory) proteins. In another embodiment, the present invention relates to a kit for introducing modified nucleosides into a nucleic acid and then covalently binding such a nucleic acid to a support.

  本发明涉及一种用基团修饰双链核酸的工艺，这些基团可使这些核酸与支持物或其他基质的表面共价结合。在另一个实施方案中，本发明涉及一种可根据上述方法或工艺获得的修饰核酸。在另一个实施方案中，本发明涉及一种携带共价键合修饰核酸（尤其是 DNA 或 RNA）的支持物，其中核酸通过一种或多种修饰核苷键合到所述支持物的表面。此外，本发明还涉及一种基质，该基质可以是凝胶状，可通过交联剂交联根据本发明修饰的核酸而获得。本发明还涉及一种制造这种基质的方法。本发明还涉及一种采用本发明的支持物或基质的试剂盒，特别是用于检测或纯化核酸或核酸结合蛋白（如调节蛋白）。在另一个实施方案中，本发明涉及一种试剂盒，用于将修饰的核苷引入核酸，然后将这种核酸与支持物共价结合。