acetiamine | 123293-43-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: acetiamine
• 英文别名: N-(4-acetoxy-2-acetylsulfanyl-1-methyl-but-1-enyl)-N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-formamide；N-(4-acetoxy-2-acetylmercapto-1-methyl-but-1-en-t-yl)-N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-formamide；N-(4-Acetoxy-2-acetylmercapto-1-methyl-but-1-en-t-yl)-N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-formamid；O,S-Diacetyl-thiamin；O.S-Diacetylthiamin；Diacetylthiamin；[(Z)-3-acetylsulfanyl-4-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]pent-3-enyl] acetate
• CAS: 123293-43-6
• 化学式: C₁₆H₂₂N₄O₄S
• 分子量: 366.441
• InChiKey: ISIPQAHMLLFSFR-GDNBJRDFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  141
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  盐酸硫胺 在 sodium hydroxide 、 水 作用下， 生成 acetiamine
  参考文献：
  名称：

  Gene Expression of Cyclooxygenase in the Aging Heart

  摘要：

  Cyclooxygenase (COX) is the key rate-limiting enzyme in the prostaglandin synthetic pathway. Two isoforms of COX have been identified: a constitutive COX-1 and an inducible COX-2, which is activated in response to various stimuli. We investigated the changes of COX-1 and COX-2 in rat heart during aging. We measured the age-related changes in the mRNA and protein levels of COX by using reverse-transcription polymerase chain reaction and Western blotting, respectively. COX-2 mRNA and protein levels increased with age, whereas those of COX-1 showed no change. The COX activity determined by prostaglandin E-2 production increased with age. Because the COX-catalyzed arachidonate cascade is an important source of reactive oxygen species (ROS) generation, changes in ROS generation and lipid peroxidation were also assessed. The amount of ROS generated by the COX pathway increased with age, as did the total ROS generation and lipid peroxidation. These results show that COX-2 activity increases with age, partially because of elevated transcriptional expression and protein content, and they suggest that increased COX-2 can play a role in oxidative alterations in the aged heart.

  DOI：

  10.1093/gerona/56.8.b350

文献信息

• US2752348
  申请人：——

  公开号：——

  公开（公告）日：——
• DE929551
  申请人：——

  公开号：——

  公开（公告）日：——
• Gene Expression of Cyclooxygenase in the Aging Heart
  作者：J. W. Kim、B. S. Baek、Y. K. Kim、J. T. Herlihy、Y. Ikeno、B. P. Yu、H. Y. Chung

  DOI：10.1093/gerona/56.8.b350

  日期：2001.8.1

  Cyclooxygenase (COX) is the key rate-limiting enzyme in the prostaglandin synthetic pathway. Two isoforms of COX have been identified: a constitutive COX-1 and an inducible COX-2, which is activated in response to various stimuli. We investigated the changes of COX-1 and COX-2 in rat heart during aging. We measured the age-related changes in the mRNA and protein levels of COX by using reverse-transcription polymerase chain reaction and Western blotting, respectively. COX-2 mRNA and protein levels increased with age, whereas those of COX-1 showed no change. The COX activity determined by prostaglandin E-2 production increased with age. Because the COX-catalyzed arachidonate cascade is an important source of reactive oxygen species (ROS) generation, changes in ROS generation and lipid peroxidation were also assessed. The amount of ROS generated by the COX pathway increased with age, as did the total ROS generation and lipid peroxidation. These results show that COX-2 activity increases with age, partially because of elevated transcriptional expression and protein content, and they suggest that increased COX-2 can play a role in oxidative alterations in the aged heart.