2-butoxytropone | 1002736-85-7

• 分子结构分类: 有机化合物 - 碳氢化合物衍生物 - 环庚三烯酮
• 英文名称: 2-butoxytropone
• 英文别名: 2-Butoxycyclohepta-2,4,6-trien-1-one；2-butoxycyclohepta-2,4,6-trien-1-one
• CAS: 1002736-85-7
• 化学式: C₁₁H₁₄O₂
• 分子量: 178.231
• InChiKey: ORPHSESWJQYCTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-butoxytropone 、 dimethyl azodicarboxylate 以 甲苯 为溶剂， 以61%的产率得到dimethyl 1-butoxy-2-oxo-6,7-diazabicyclo[3.2.2]nona-3,8-diene-6,7-dicarboxylate
  参考文献：
  名称：

  新型二氮杂双环托酚酮衍生物的合成和体外杀原虫评价

  摘要：

  介绍了基于托酚酮醚的 27 种新型二氮杂双环的合成和体外抗寄生虫活性。这些化合物可以使用简单易得的起始材料，通过高产率的杂 Diels-Alder 反应很容易地制备。一些新的二氮杂双环化合物对克氏锥虫、杜氏利什曼原虫、罗得西亚布氏锥虫和耐氯喹恶性疟原虫具有体外活性，与目前使用的原生动物杀灭剂相当或更好。

  DOI：

  10.1002/ardp.200700143
• 作为产物：
  描述：

  正溴丁烷 、 环庚三烯酚酮 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 以62%的产率得到2-butoxytropone
  参考文献：
  名称：

  新型二氮杂双环托酚酮衍生物的合成和体外杀原虫评价

  摘要：

  介绍了基于托酚酮醚的 27 种新型二氮杂双环的合成和体外抗寄生虫活性。这些化合物可以使用简单易得的起始材料，通过高产率的杂 Diels-Alder 反应很容易地制备。一些新的二氮杂双环化合物对克氏锥虫、杜氏利什曼原虫、罗得西亚布氏锥虫和耐氯喹恶性疟原虫具有体外活性，与目前使用的原生动物杀灭剂相当或更好。

  DOI：

  10.1002/ardp.200700143

文献信息

• THERMALLY-ACTIVATED SELF-IMMOLATIVE MATERIALS
  申请人：UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

  公开号：US20150368403A1

  公开（公告）日：2015-12-24

  A polymer including a self-immolative polymer segment and a thermally-activated trigger moiety is described. The self-immolative polymer segment includes a head end, a tail end, and a plurality of repeating units. The trigger moiety includes a cycloaddition adduct that is covalently coupled to the head end of the self-immolative polymer segment. When the polymer is exposed to an activation temperature, the cycloaddition adduct undergoes retro-cycloaddition to release the self-immolative polymer segment. The self-immolative polymer segment then decomposes to sequentially release repeating units in a head-to-tail direction.
• US9580553B2
  申请人：——

  公开号：US9580553B2

  公开（公告）日：2017-02-28
• [EN] THERMALLY-ACTIVATED SELF-IMMOLATIVE MATERIALS<br/>[FR] MATÉRIAUX AUTO-IMMOLATEURS THERMO-ACTIVÉS
  申请人：UNIV WASHINGTON CT COMMERCIALI

  公开号：WO2014133620A2

  公开（公告）日：2014-09-04

  A polymer including a self-immolative polymer segment and a thermally-activated trigger moiety is described. The self-immolative polymer segment includes a head end, a tail end, and a plurality of repeating units. The trigger moiety includes a cycloaddition adduct that is covalently coupled to the head end of the self-immolative polymer segment. When the polymer is exposed to an activation temperature, the cycloaddition adduct undergoes retro-cycloaddition to release the self-immolative polymer segment. The self-immolative polymer segment then decomposes to sequentially release repeating units in a head-to-tail direction.
• Synthesis andIn VitroProtozoocidal Evaluation of Novel Diazabicyclic Tropolone Derivatives
  作者：Alexander Khrizman、Rachel D. Slack、Richard C. Remsing、Susan Little、Vanessa Yardley、Guillermo Moyna

  DOI：10.1002/ardp.200700143

  日期：2007.11

  The synthesis and in vitro antiparasitic activity of twenty‐seven novel diazabicycles based on tropolone ethers is presented. The compounds can be readily prepared by means of a high‐yielding hetero Diels–Alder reaction using simple and readily available starting materials. Several of the new diazabicycles have in vitro activities against Trypanosoma cruzi, Leishmania donovani, Trypanosoma brucei rhodesiense

  介绍了基于托酚酮醚的 27 种新型二氮杂双环的合成和体外抗寄生虫活性。这些化合物可以使用简单易得的起始材料，通过高产率的杂 Diels-Alder 反应很容易地制备。一些新的二氮杂双环化合物对克氏锥虫、杜氏利什曼原虫、罗得西亚布氏锥虫和耐氯喹恶性疟原虫具有体外活性，与目前使用的原生动物杀灭剂相当或更好。