1-((2R)-hydroxy-(1S)-methyl-2-phenylethyl)-1H-pyrimidine-2,4-dione | 305846-77-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-((2R)-hydroxy-(1S)-methyl-2-phenylethyl)-1H-pyrimidine-2,4-dione
• 英文别名: 1-[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]pyrimidine-2,4-dione
• CAS: 305846-77-9
• 化学式: C₁₃H₁₄N₂O₃
• 分子量: 246.266
• InChiKey: MYOPKBRKUVSGLT-CABZTGNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-((2R)-hydroxy-(1S)-methyl-2-phenylethyl)-1H-pyrimidine-2,4-dione 、 碘甲烷 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以66%的产率得到1-((2R)-methoxy-(1S)-methyl-2-phenylethyl)-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  An Efficient Synthesis of a New Series of Acyclonucleosides Starting from β-Amino Alcohols

  摘要：

  A series of new acyclonucleosides analogues 3 has been synthesized very efficiently in three steps starting from beta-amino alcohols 1. The key step of this process is a nucleophilic substitution with various nucleophiles on 2,2'-anhydronucleosides 2. The chemo- and stereoselectivities of this reaction are discussed. AM1 calculations sustained the observed chemoselectivity.

  DOI：

  10.1021/jo000812d
• 作为产物：
  描述：

  去甲麻黄碱 在 sodium hydroxide 、 水 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 19.0h， 生成 1-((2R)-hydroxy-(1S)-methyl-2-phenylethyl)-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  An Efficient Synthesis of a New Series of Acyclonucleosides Starting from β-Amino Alcohols

  摘要：

  A series of new acyclonucleosides analogues 3 has been synthesized very efficiently in three steps starting from beta-amino alcohols 1. The key step of this process is a nucleophilic substitution with various nucleophiles on 2,2'-anhydronucleosides 2. The chemo- and stereoselectivities of this reaction are discussed. AM1 calculations sustained the observed chemoselectivity.

  DOI：

  10.1021/jo000812d

文献信息

• An Efficient Synthesis of a New Series of Acyclonucleosides Starting from β-Amino Alcohols
  作者：Claude Agami、Luc Dechoux、Louis Hamon、Mohand Melaimi

  DOI：10.1021/jo000812d

  日期：2000.10.1

  A series of new acyclonucleosides analogues 3 has been synthesized very efficiently in three steps starting from beta-amino alcohols 1. The key step of this process is a nucleophilic substitution with various nucleophiles on 2,2'-anhydronucleosides 2. The chemo- and stereoselectivities of this reaction are discussed. AM1 calculations sustained the observed chemoselectivity.