N-{2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl}benzamide | 919103-21-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-{2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl}benzamide
• 英文别名: N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]benzamide
• CAS: 919103-21-2
• 化学式: C₁₄H₁₅N₃O₂
• 分子量: 257.292
• InChiKey: ZABQVUZXDYHZPO-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  73.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  马尿酸 、 (S)-吡咯烷-2-腈 在 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-{2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl}benzamide
  参考文献：
  名称：

  WO2007/5991

  摘要：

  公开号：

文献信息

• Inhibitors of Fibroblast Activation Protein Alpha
  申请人：Bachovchin William W.

  公开号：US20090221818A1

  公开（公告）日：2009-09-03

  Disclosed are peptide-based compounds that include boronic acid or cyano functionality, which efficiently and selectively inhibit fibroblast activation protein alpha. Among other therapeutic utilities, the peptide-based compounds may be useful for the treatment of cancer.
• Substrates and Inhibitors of Antiplasmin Cleaving Enzyme and Fibroblast Activation Protein and Methods of Use
  申请人：The Board of Regents of the University of Oklahoma

  公开号：US20150141660A1

  公开（公告）日：2015-05-21

  The presently disclosed and claimed inventive concepts include inhibitors of antiplasmin cleaving enzyme (APCE) and fibroblast activation protein alpha (FAP) which can be used in various therapies related to disorders of fibrin and α 2 -antiplasmin and abnormal cell proliferation. The presently disclosed and claimed inventive concepts also include substrates of APCE and FAP, which may be used, for example, in screening methods for identifying such inhibitors. The presently disclosed and claimed inventive concepts further include, but are not limited to, methods of treating or inhibiting atherosclerosis and thrombus disorders by altering the ratios of types of plasma α 2 -antiplasmin and to methods of treating conditions involving abnormal cell proliferation such as cancers.
• US7998997B2
  申请人：——

  公开号：US7998997B2

  公开（公告）日：2011-08-16
• US8933201B2
  申请人：——

  公开号：US8933201B2

  公开（公告）日：2015-01-13
• US9527884B2
  申请人：——

  公开号：US9527884B2

  公开（公告）日：2016-12-27