5-nitro-2-(2-carboxy-ethyl)-benzoic acid | 90945-77-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-nitro-2-(2-carboxy-ethyl)-benzoic acid
• 英文别名: 2-<2'-Carboxylaethyl>-5-nitro-benzoesaeure；2-carboxy-4-nitro-hydrocinnamic acid；2-(2-Carboxyethyl)-5-nitrobenzoic acid
• CAS: 90945-77-0
• 化学式: C₁₀H₉NO₆
• 分子量: 239.185
• InChiKey: COXOGSDVLCVYHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  120
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-nitro-2-(2-carboxy-ethyl)-benzoic acid 在 palladium on activated charcoal 盐酸 、 sodium hydroxide 、 tetrafluoroboric acid 、 三氯化铝 、 sodium azide 、 氢气 、 三乙胺 、 sodium chloride 、 sodium nitrite 作用下， 以 乙醚 为溶剂， 反应 23.5h， 生成 6-azido-1-oxo-indan-4-carboxylic acid
  参考文献：
  名称：

  Synthesis of 6-azido-1-oxo-indan-4-oyl isoleucine; a photoaffinity approach to plant signaling

  摘要：

  The synthesis of the photoreactive 6-azido-1-oxo-indanoyl isoleucine (3), as a molecular probe for the identification of putative receptors and binding proteins involved in stress signaling of plants, is described. The biological activity of the photolabile azide 3 comes close to that of the bacterial phytotoxin coronatine (1). Photodecomposition of 3 in the presence of myoglobin is assumed to proceed via an didehydroazepine intermediate and results in significant binding of the probe to the model protein. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00097-6

文献信息

• Enzyme modulators and treatments
  申请人：Flynn L. Daniel

  公开号：US20070078121A1

  公开（公告）日：2007-04-05

  Novel compounds and methods of using those compounds for the treatment of inflammatory conditions, immunological disorders, hyperproliferative diseases, cancer, and diseases characterized by hyper-vascularization are provided. In a preferred embodiment, modulation of the activation state of kinases, including p38 kinase protein, abl kinase protein, bcr-abl kinase protein, braf kinase protein, VEGFR kinase protein, or PDGFR kinase protein, comprises the step of contacting said kinase protein with the novel compounds.

  提供了新型化合物及其使用方法，用于治疗炎症性疾病、免疫性疾病、过度增生性疾病、癌症以及以高血管化为特征的疾病。在一种优选实施方式中，调节激酶的激活状态，包括p38激酶蛋白、abl激酶蛋白、bcr-abl激酶蛋白、braf激酶蛋白、VEGFR激酶蛋白或PDGFR激酶蛋白，包括将该激酶蛋白与新型化合物接触的步骤。
• ENZYME MODULATORS AND TREATMENTS
  申请人：Flynn L. Daniel

  公开号：US20080113967A1

  公开（公告）日：2008-05-15

  Novel compounds and methods of using those compounds for the treatment of inflammatory conditions, hyperproliferative diseases, cancer, and diseases characterized by hyper-vascularization are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein, abl kinase protein, ber-abl kinase protein, braf kinase protein, VEGFR kinase protein, or PDGFR kinase protein comprises the step of contacting said kinase protein with the novel compounds.

  本发明提供了新的化合物及其使用方法，用于治疗炎症状况、过度增殖性疾病、癌症和以高血管化为特征的疾病。在优选实施例中，调节p38激酶蛋白、abl激酶蛋白、ber-abl激酶蛋白、braf激酶蛋白、VEGFR激酶蛋白或PDGFR激酶蛋白的激活状态，包括将该激酶蛋白与新的化合物接触的步骤。
• US8163756B2
  申请人：——

  公开号：US8163756B2

  公开（公告）日：2012-04-24
• Synthesis of 6-azido-1-oxo-indan-4-oyl isoleucine; a photoaffinity approach to plant signaling
  作者：Göde Schüler、Claus Wasternack、Wilhelm Boland

  DOI：10.1016/s0040-4020(99)00097-6

  日期：1999.3

  The synthesis of the photoreactive 6-azido-1-oxo-indanoyl isoleucine (3), as a molecular probe for the identification of putative receptors and binding proteins involved in stress signaling of plants, is described. The biological activity of the photolabile azide 3 comes close to that of the bacterial phytotoxin coronatine (1). Photodecomposition of 3 in the presence of myoglobin is assumed to proceed via an didehydroazepine intermediate and results in significant binding of the probe to the model protein. (C) 1999 Elsevier Science Ltd. All rights reserved.