N-(6-(trifluoromethyl)pyridin-2-yl)picolinamide | 1161205-23-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-(6-(trifluoromethyl)pyridin-2-yl)picolinamide
• 英文别名: N-[6-(trifluoromethyl)pyridin-2-yl]pyridine-2-carboxamide
• CAS: 1161205-23-7
• 化学式: C₁₂H₈F₃N₃O
• 分子量: 267.21
• InChiKey: FQPIEHXRKMCSSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  54.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-吡啶甲酸 、 2-氨基-6-(三氟甲基)吡啶 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 作用下， 以 1,4-二氧六环 为溶剂， 以86%的产率得到N-(6-(trifluoromethyl)pyridin-2-yl)picolinamide
  参考文献：
  名称：

  Synthesis and Evaluation of a Series of Heterobiarylamides That Are Centrally Penetrant Metabotropic Glutamate Receptor 4 (mGluR4) Positive Allosteric Modulators (PAMs)

  摘要：

  We report the synthesis and evaluation of a series or heterobiaryl amides as positive allosteric modulators of mGluR4. Compounds 9b and 9c showed submicromolar potency at both human and rat mGluR4. In addition, both 9b and 9c were shown to be centrally penetrant in rats using nontoxic vehicles, a major advance for the mGluR4 field.

  DOI：

  10.1021/jm9005065

文献信息

• Synthesis and Evaluation of a Series of Heterobiarylamides That Are Centrally Penetrant Metabotropic Glutamate Receptor 4 (mGluR4) Positive Allosteric Modulators (PAMs)
  作者：Darren W. Engers、Colleen M. Niswender、C. David Weaver、Satyawan Jadhav、Usha N. Menon、Rocio Zamorano、P. Jeffrey Conn、Craig W. Lindsley、Corey R. Hopkins

  DOI：10.1021/jm9005065

  日期：2009.7.23

  We report the synthesis and evaluation of a series or heterobiaryl amides as positive allosteric modulators of mGluR4. Compounds 9b and 9c showed submicromolar potency at both human and rat mGluR4. In addition, both 9b and 9c were shown to be centrally penetrant in rats using nontoxic vehicles, a major advance for the mGluR4 field.