[(4'-methylbiphenyl-2-yl)methylidene]propanedioic acid | 1290560-41-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(4'-methylbiphenyl-2-yl)methylidene]propanedioic acid
• 英文别名: 2-[[2-(4-Methylphenyl)phenyl]methylidene]propanedioic acid
• CAS: 1290560-41-6
• 化学式: C₁₇H₁₄O₄
• 分子量: 282.296
• InChiKey: QGQXOZSLAPDVLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  [(4'-methylbiphenyl-2-yl)methylidene]propanedioic acid 在 三氟化硼乙醚 作用下， 以 乙醚 为溶剂， 反应 20.0h， 以100%的产率得到(2-methyl-9H-fluoren-9-yl)propanedioic acid
  参考文献：
  名称：

  First and mild synthesis of fluorene-9-malonic acid and some substituted derivatives via the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids

  摘要：

  Hitherto unknown fluorene-9-malonic acid and some substituted derivatives were easily synthesized in very mild conditions through the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids issued from the corresponding biphenylcarboxaldehydes. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.02.026
• 作为产物：
  描述：

  4-甲苯硼酸 在 四(三苯基膦)钯 、 potassium phosphate monohydrate 、 ammonium acetate 作用下， 以 乙二醇二甲醚 、 乙醇 为溶剂， 20.0~150.0 ℃ 、600.01 kPa 条件下， 反应 2.25h， 生成 [(4'-methylbiphenyl-2-yl)methylidene]propanedioic acid
  参考文献：
  名称：

  First and mild synthesis of fluorene-9-malonic acid and some substituted derivatives via the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids

  摘要：

  Hitherto unknown fluorene-9-malonic acid and some substituted derivatives were easily synthesized in very mild conditions through the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids issued from the corresponding biphenylcarboxaldehydes. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.02.026

文献信息

• New imidazopyridine derivatives as angiotensin II antagonists
  申请人：J. URIACH & CIA. S.A.

  公开号：EP0669333A1

  公开（公告）日：1995-08-30

  The present invention relates to new imidazopyridine derivatives of formula I wherein: one of A, B, C and D is N and the other are CR, wherein each R independently represents hydrogen, C1-4 alkyl, COOH or halogen; R1 represents C1-4 alkyl or C3-7 cycloalkyl; Ar1 represents phenylene or pyridylene which can be optionally substituted; V represents C1-4 alkyl, C3-7 cycloalkyl, aryl, aryl-(C1-4)alkyl or a 5- or 6-membered aromatic heterocycle; the group X-Y represents C = C or CH-CR3; R3 represents hydrogen, C1-4 alkyl or aryl-(C1-4)alkyl; Z represents among others -CO2R4, -tetrazol-5-yl, -CONHS02R4, -CONR4R5, -CH2NHSO2R4; R4 and R5 independently represent hydrogen, C1-4 alkyl, aryl, aryl-(C1-4)alkyl or perfluoro-(C1-4)alkyl; W represents hydrogen, cyano, C1-4 alkyl, C1-4 haloalkyl, C3-7 cycloalkyl, aryl, aryl-(C1-4)alkyl, C1 -4 alkylsulfonyl, C1 -4 alkylsulfinyl, C1 -4 alkylthio, C1 -4 alkoxy, C1-4 alkylcarbonyl, halogen, hydroxymethyl or C1-4 alkoxymethyl, or W can have any of the meanings disclosed for Z. These compounds are angiotensin II antagonists.

  本发明涉及公式I的新咪唑吡啶衍生物，其中：A、B、C和D中的一个为N，另外三个为CR，其中每个R独立地代表氢、C1-4烷基、COOH或卤素；R1代表C1-4烷基或C3-7环烷基；Ar1代表苯基或吡啶基，可以选择性地被取代；V代表C1-4烷基、C3-7环烷基、芳基、芳基-(C1-4)烷基或5-或6-成员芳香杂环；X-Y基团代表C = C或CH-CR3；R3代表氢、C1-4烷基或芳基-(C1-4)烷基；Z代表等等的基团之一，如-CO2R4、-四唑-5-基、-CONHSO2R4、-CONR4R5、-CH2NHSO2R4；R4和R5独立地代表氢、C1-4烷基、芳基、芳基-(C1-4)烷基或全氟-(C1-4)烷基；W代表氢、氰基、C1-4烷基、C1-4卤代烷基、C3-7环烷基、芳基、芳基-(C1-4)烷基、C1-4烷基磺酰基、C1-4烷基亚砜基、C1-4烷基硫基、C1-4烷氧基、C1-4烷基羰基、卤素、羟甲基或C1-4烷氧甲基，或W可以具有Z所披露的任何含义。这些化合物是血管紧张素II拮抗剂。
• US5554624A
  申请人：——

  公开号：US5554624A

  公开（公告）日：1996-09-10