N,N'-bis-salicylidenamino-guanidine | 91379-47-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N,N'-bis-salicylidenamino-guanidine
• 英文别名: N,N'-Bis-salicylidenamino-guanidin；1,2-bis[(E)-(2-hydroxyphenyl)methylideneamino]guanidine
• CAS: 91379-47-4
• 化学式: C₁₅H₁₅N₅O₂
• 分子量: 297.316
• InChiKey: HSTUAUQOBCWZDR-BEQMOXJMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  水杨醛 、 二氨基胍 在 氢溴酸 作用下， 生成 N,N'-bis-salicylidenamino-guanidine
  参考文献：
  名称：

  Gaiter, Gazzetta Chimica Italiana, 1915, vol. 45 I, p. 457

  摘要：

  DOI：

文献信息

• Compounds and methods of treating infections
  申请人：Neoculi Pty Ltd.

  公开号：US10253002B2

  公开（公告）日：2019-04-09

  The invention provides compounds of Formula I, and methods of treating or preventing a bacterial infection in a subject using a compound of Formula I. The invention also provides the use of a compound of Formula I in the manufacture of a medicament for the treatment of a bacterial infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a bacterial infection in a subject and to a medical device comprising the composition of the invention.

  本发明提供了式 I 化合物，以及使用式 I 化合物治疗或预防受试者细菌感染的方法。本发明还提供了式 I 化合物在制造治疗受试者细菌感染的药物中的用途。本发明进一步提供了一种用于治疗或预防受试者细菌感染方法中的医疗器械，以及包含本发明组合物的医疗器械。
• Methods for treating protozoan infections
  申请人：Neoculi Pty Ltd.

  公开号：US10392363B2

  公开（公告）日：2019-08-27

  The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention.

  本发明提供了式(I)化合物及其在使用式(I)化合物治疗或预防受试者原生动物感染的方法中的用途。本发明还提供了式 (I) 化合物在制造治疗受试者原生动物感染的药物中的用途。本发明进一步提供了一种用于治疗或预防受试者原生动物感染方法中的医疗器械，以及包含本发明组合物的医疗器械。
• COMPOUNDS AND METHODS OF TREATING INFECTIONS
  申请人：Neoculi Pty Ltd

  公开号：EP2991968B1

  公开（公告）日：2021-11-10
• METHODS FOR TREATING PROTOZOAN INFECTIONS
  申请人：Neoculi Pty Ltd

  公开号：EP3188722B1

  公开（公告）日：2021-08-04
• [EN] COMPOUNDS AND METHODS OF TREATING INFECTIONS<br/>[FR] COMPOSÉS ET MÉTHODES DE TRAITEMENT D'INFECTIONS
  申请人：NEOCULI PTY LTD

  公开号：WO2014176636A1

  公开（公告）日：2014-11-06

  The invention provides compounds of Formula (I), and methods of treating or preventing a bacterial infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a bacterial infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a bacterial infection in a subject and to a medical device comprising the composition of the invention.