trans-1,2-Dimethoxycarbonyl-1-phenylcyclopropane | 723-19-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: trans-1,2-Dimethoxycarbonyl-1-phenylcyclopropane
• 英文别名: (+/-)-1-Phenyl-cyclopropan-1r.2t-dicarbonsaeure-dimethylester；trans-1-Phenyl-1,2-dimethoxycarbonyl-cyclopropan；dimethyl (1R,2R)-1-phenylcyclopropane-1,2-dicarboxylate
• CAS: 723-19-3；39822-28-1；39822-29-2；55221-25-5；55221-26-6
• 化学式: C₁₃H₁₄O₄
• 分子量: 234.252
• InChiKey: UAOJFWUVNVCTPQ-GWCFXTLKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.29
• 重原子数：
  17.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  52.6
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  DL-扁桃酸甲酯 在 吡啶 、 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 苯 为溶剂， 生成 trans-1,2-Dimethoxycarbonyl-1-phenylcyclopropane
  参考文献：
  名称：

  Nishiyama, Kazuyoshi; Inouye, Yuzo, Agricultural and Biological Chemistry, 1982, vol. 46, # 4, p. 1027 - 1034

  摘要：

  DOI：

文献信息

• Stereoselectivity of a polymer supported reaction
  作者：I. Artaud、P. Viout

  DOI：10.1016/s0040-4039(01)82852-5

  日期：1981.1

  PhCH2 - CO2 - and CH2 = CH - CO2 - in a soluble chloromethylated polystyrene leads to polymer supported esters which were used for the preparation of cyclopropyl derivatives. For the first time at our knowledge, a reaction was performed between two funntionalized polymers. The polymer backbone effect on the reaction with one or two bound reagents is not large, and it depends on the temperature.

  在可溶性氯甲基化的聚苯乙烯中被PhCH 2 -CO 2-和CH 2 = CH-CO 2-取代Cl导致聚合物负载的酯，该酯用于制备环丙基衍生物。据我们所知，这是第一次在两种官能化的聚合物之间进行反应。聚合物主链对与一种或两种结合试剂的反应的影响不大，并且取决于温度。
• <b>Three-membered Rings. IV. Solvent Control for the Stereoselective Formation of Cyclopropanes Substituted at Two of the Ring Carbons</b>
  作者：Layton L. McCoy

  DOI：10.1021/ja00870a044

  日期：1962.6
• Synthesis of racemic cis-1-alkyl- and 1-aryl-2-aminocyclopropanecarboxylic esters
  作者：Sven Mangelinckx、Norbert De Kimpe

  DOI：10.1016/s0040-4039(03)00126-6

  日期：2003.2

  The title cyclic beta-amino esters were synthesized stereo- and regioselectively. Starting from the corresponding 1-aryl- and 1-alkylcyclopropane-1,2-dicarboxylates, selective monosaponification and subsequent Curtius reaction leads to certain cis-1-alkyl-and 1-aryl-2-aminocyclopropanecarboxylic esters. These P-aminocyclopropanecarboxylate derivatives (beta-ACCs) can be seen as useful building blocks for beta-peptides. (C) 2003 Elsevier Science Ltd. All rights reserved.
• Synthetic reactions by complex catalysts. XXX. Synthesis of cyclic compounds by means of copper-isonitrile complex. Copper(I) carbenoid intermediate
  作者：Takeo Saegusa、Kazuya Yonezawa、Ichiki Murase、Toshiro Konoike、Shimpei Tomita、Yoshihiko Ito

  DOI：10.1021/jo00953a011

  日期：1973.6
• A Convenient Synthesis of Polysubstituted Cyclopropanes
  作者：H. Fauduet、R. Burgada

  DOI：10.1055/s-1980-29152

  日期：——