2-phenyl-1,4-pentadien-3-ol | 907997-19-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-phenyl-1,4-pentadien-3-ol
• 英文别名: 2-Phenylpenta-1,4-dien-3-ol
• CAS: 907997-19-7
• 化学式: C₁₁H₁₂O
• 分子量: 160.216
• InChiKey: OPVJTVHFNGAKHJ-UHFFFAOYSA-N

物化性质

• 沸点：
  273.2±9.0 °C(Predicted)
• 密度：
  0.993±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-phenyl-1,4-pentadien-3-ol 在 manganese(IV) oxide 、 氢氧化钾 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 3-phenyltetrahydro-4H-pyran-4-one
  参考文献：
  名称：

  Synthesis of 3-Aryl-Substituted Tetrahydropyran-4-ones and Tetrahydrothiopyran-4-ones

  摘要：

  一系列具有3-芳基或3,6-二芳基取代基的四氢吡営-4-酮和四氢硫代吡喃-4-酮衍生物通过双共轭加成水或H2S到二乙烯基酮中制备。这些起始材料通过两步法获得：将锂化的α-溴苯乙烯衍生物与丙烯醛或肉桂醛进行转化，随后用MnO2氧化二乙烯基醇。

  DOI：

  10.1055/s-2006-941572
• 作为产物：
  描述：

  苯乙酮 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 4.75h， 生成 2-phenyl-1,4-pentadien-3-ol
  参考文献：
  名称：

  通过关注4-二甲基氨基-3-苯基哌啶衍生物的苯基取代基开发κ阿片受体激动剂：苦参碱类生物碱的结构-活性关系研究。

  摘要：

  从苦参碱型生物碱先导化合物4-二甲基氨基-1-戊酰基哌啶（3）开发了一系列新的κ阿片受体（KOR）激动剂。合成了具有多种苯基取代基的3衍生物，并评估了它们的抗伤害感受作用。此外，研究了它们对阿片受体对cis-4c和d以及trans-4g的选择性，它们均具有通过KOR发挥的高活性。

  DOI：

  10.1248/cpb.c15-00963

文献信息

• Synthesis of Tetrahydropyran-4-ones and Thiopyran-4-ones from Donor-Substituted α-Bromostyrene Derivatives
  作者：Anna Rosiak、Wolfgang Frey、Jens Christoffers

  DOI：10.1002/ejoc.200600372

  日期：2006.9

  Tetrahydropyran-4-one and tetrahydrothiopyran-4-one derivatives with a 3-aryl substituent were synthesized by double-conjugate addition of water or H2S to divinyl ketones. These starting materials were prepared in two steps by conversion of lithiated α-bromostyrene derivatives with acrolein or cinnamaldehyde and subsequent oxidation of the divinyl alcohols with MnO2. The electron-rich α-bromostyrene

  具有 3-芳基取代基的四氢​​吡喃-4-one 和四氢噻喃-4-one 衍生物通过水或 H2S 与二乙烯基酮的双共轭加成合成。通过用丙烯醛或肉桂醛转化锂化的 α-溴苯乙烯衍生物，然后用 MnO2 氧化二乙烯醇，分两步制备这些原料。富含电子的 α-溴苯乙烯构件是通过在严格无水条件下将 HBr 添加到相应的炔烃中来制备的，这在数克规模上可靠地工作。已经探索了两种具有特定取代模式的芳基乙炔路线；然而，在更大的范围内，只有 Corey-Fuchs 序列被证明是可行的。（© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006）
• Synthesis of 3-Phenyl-4-piperidones from Acetophenone by Shapiro and Aza-Michael Reactions and Their Further Derivatization
  作者：Anna Rosiak、Christoph Hoenke、Jens Christoffers

  DOI：10.1002/ejoc.200700325

  日期：2007.9

  The Shapiro reaction of acetophenone is the key in a convenient three-step access to a divinyl ketone which is further transformed by double aza-Michael reactions with primary amines into N-substituted 3-phenyl-4-piperidones. In the case of N-benzyl and N-allyl derivatives, the piperidine nitrogen atom can be deprotected and further functionalized, for example, by carboxamide, carbamate, or urea formation

  苯乙酮的夏皮罗反应是方便三步获得二乙烯基酮的关键，二乙烯基酮通过与伯胺的双氮杂-迈克尔反应进一步转化为 N-取代的 3-苯基-4-哌啶酮。在 N-苄基和 N-烯丙基衍生物的情况下，哌啶氮原子可以脱保护并进一步官能化，例如通过甲酰胺、氨基甲酸酯或尿素的形成。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim , 德国, 2007)
• POLYPHENYLENE ETHER RESIN COMPOSITION
  申请人：MITSUBISHI CHEMICAL CORPORATION

  公开号：EP0765914A1

  公开（公告）日：1997-04-02

  A polyphenylene ether resin composition containing the following Components (A) to (D) according at the following formulation ratio. (A) 50 to 99.5 parts by weight of a polyphenylene ether (B) 0.1 to 50 parts by weight of a partially hydrogenated aromatic alkenyl compound-conjugated diene block copolymer having a hydroxy group and based on 100 parts by weight of the above resin composition, (C) 0 to 950 parts by weight of a thermoplastic resin and (D) 0 to 10 parts by weight of a phosphorous acid triester

  一种聚苯醚树脂组合物，按以下配比含有以下成分（A）至（D）。 (A) 50 至 99.5 重量份的聚苯醚 (B) 0.1 至 50 份（按重量计）具有羟基的部分氢化芳香族烯基化合物-共轭 二烯嵌段共聚物 以上述树脂组合物 100 份重量计、 (C) 0 至 950 重量份的热塑性树脂 和 (D) 0 至 10 份(重量)的磷酸三酯
• SILANE COMPOUND, PRODUCTION METHOD THEREOF, AND RESIN COMPOSITION CONTAINING SILANE COMPOUND
  申请人：Sugioka Takuo

  公开号：US20100317774A1

  公开（公告）日：2010-12-16

  The present invention provides a silane compound which can be preferably used in an electronics application and the like, as a resin composition which is excellent in heat resistance, pressure resistance, water resistance, low moisture absorption property, low dielectric property, mechanical and chemical stability, and heat conductivity and capable of forming cured articles which hardly reduce physical properties even under severe environments such as high temperature and high pressure and high humidity; its production method, and a resin composition containing the silane compound. The silane compound of the present invention provides a silane compound having a siloxane bond and an imido bond, wherein the silane compound comprises a structure unit formed by connecting at least one organic skeleton having an imido bond to a silicon atom forming a siloxane bond, wherein the silane compound is defined by the following average composition formula: XaYbZcSiOd in the formula, X may be same or different and denotes a group including an organic skeleton having an imido bond, represented by the following formula (1); Z may be same or different and denotes an organic group having no imido bond; Y may be same or different and denotes at least one selected from the group consisting of hydrogen atom, hydroxyl group, halogen atom, and OR group; R may be same or different and denotes at least one selected from the group consisting of alkyl, acyl, aryl, and unsaturated aliphatic residual groups and may have a substituent; a is a numeral of 3 or lower but not 0; b is 0 or a numeral less than 3; c is 0 or a numeral less than 3; d is a numeral less than 2 but not 0; and a+b+c+2d=4, in the formula, R 1 denotes at least one structure selected from the group consisting of aromatic, heterocyclic, and alicyclic rings; x and z may be same or different and independently denote an integer of 0 or higher and 5 or lower; and y is 0 or 1.
• US5717014A
  申请人：——

  公开号：US5717014A

  公开（公告）日：1998-02-10