(1S)-N-benzyl-N-[[benzyl-[(1S)-1-phenylethyl]amino]disulfanyl]-1-phenylethanamine | 1381846-45-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1S)-N-benzyl-N-[[benzyl-[(1S)-1-phenylethyl]amino]disulfanyl]-1-phenylethanamine
• CAS: 1381846-45-2
• 化学式: C₃₀H₃₂N₂S₂
• 分子量: 484.729
• InChiKey: GTZZHTYBLFCCIT-UIOOFZCWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  57.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二氯化二硫 、 (S)-(-)-N-苄基-1-苯基-乙胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以58%的产率得到(1S)-N-benzyl-N-[[benzyl-[(1S)-1-phenylethyl]amino]disulfanyl]-1-phenylethanamine
  参考文献：
  名称：

  Synthesis and antimicrobial activities of structurally novel S,S′-bis(heterosubstituted) disulfides

  摘要：

  The central focus of this study is on the antibacterial and antifungal properties of synthetically produced S,S'-bis(heterosubstituted) disulfides as a means to control the growth of various infection-causing pathogens. Staphylococcus aureus, Francisella tularensis and Candida albicans were each found to be highly susceptible to several of these compounds by agar or broth dilution and Kirby-Bauer diffusion assays. These structurally simple, low molecular weight disulfides have shown promising bioactivities and may serve as leads to the development of effective new antibacterials for pathogenic bacteria such as methicillinresistant S. aureus and F. tularensis. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.056

文献信息

• Synthesis and antimicrobial activities of structurally novel S,S′-bis(heterosubstituted) disulfides
  作者：Praveen Ramaraju、Danielle Gergeres、Edward Turos、Sonja Dickey、Daniel V. Lim、John Thomas、Burt Anderson

  DOI：10.1016/j.bmcl.2012.04.056

  日期：2012.6

  The central focus of this study is on the antibacterial and antifungal properties of synthetically produced S,S'-bis(heterosubstituted) disulfides as a means to control the growth of various infection-causing pathogens. Staphylococcus aureus, Francisella tularensis and Candida albicans were each found to be highly susceptible to several of these compounds by agar or broth dilution and Kirby-Bauer diffusion assays. These structurally simple, low molecular weight disulfides have shown promising bioactivities and may serve as leads to the development of effective new antibacterials for pathogenic bacteria such as methicillinresistant S. aureus and F. tularensis. (C) 2012 Elsevier Ltd. All rights reserved.