2-Phenyl-2-(2-(2-phenyl-1,3-dithiolan-2-yl)ethyl)thiazolidine | 156000-22-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫代缩醛
• 英文名称: 2-Phenyl-2-(2-(2-phenyl-1,3-dithiolan-2-yl)ethyl)thiazolidine
• 英文别名: 2-phenyl-2-[2-(2-phenyl-1,3-dithiolan-2-yl)ethyl]-1,3-thiazolidine
• CAS: 156000-22-5
• 化学式: C₂₀H₂₃NS₃
• 分子量: 373.607
• InChiKey: KKJPYXOFTLNARN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  87.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,2-联苯甲酰乙烷 、 alkaline earth salt of/the/ methylsulfuric acid 在 吡啶 、 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 20.0h， 生成 2-Phenyl-2-(2-(2-phenyl-1,3-dithiolan-2-yl)ethyl)thiazolidine
  参考文献：
  名称：

  New γ-thiazolidine-1,3-dithiolanes as radioprotectors

  摘要：

  Fourteen gamma-thiazolidine-1,3-dithiolanes were prepared and tested as radioprotective agents. The combination within a single molecule of thiazolidine and dithiolane moieties, both of which are known for their radioprotective properties, was achieved for the first time. Several molecules show significant radioprotective activity: immediate 4l; delayed 4b, 4f, 4h; or immediate and prolonged 4a.

  DOI：

  10.1016/0223-5234(94)90208-9

文献信息

• New γ-thiazolidine-1,3-dithiolanes as radioprotectors
  作者：Ho Law、MH Péra、G Taillandier、M Fatome、JD Laval、G Leclerc

  DOI：10.1016/0223-5234(94)90208-9

  日期：1994.1

  Fourteen gamma-thiazolidine-1,3-dithiolanes were prepared and tested as radioprotective agents. The combination within a single molecule of thiazolidine and dithiolane moieties, both of which are known for their radioprotective properties, was achieved for the first time. Several molecules show significant radioprotective activity: immediate 4l; delayed 4b, 4f, 4h; or immediate and prolonged 4a.