2-[1,1-dimethyl-2-(methylthio)ethyl]pyridine | 103905-23-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-[1,1-dimethyl-2-(methylthio)ethyl]pyridine
• 英文别名: Pyridine, 2-[1,1-dimethyl-2-(methylthio)ethyl]-；2-(2-methyl-1-methylsulfanylpropan-2-yl)pyridine
• CAS: 103905-23-3
• 化学式: C₁₀H₁₅NS
• 分子量: 181.302
• InChiKey: PIMPKLNAUWMQNK-UHFFFAOYSA-N

物化性质

• 沸点：
  268.0±23.0 °C(Predicted)
• 密度：
  1.008±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-乙基吡啶 在 正丁基锂 、 potassium diisopropylamide 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 生成 2-[1,1-dimethyl-2-(methylthio)ethyl]pyridine
  参考文献：
  名称：

  On the metallation of 2-isopropylpyridine

  摘要：

  2-Isopropylpyridine has been successfully metallated and functionalized by using potassium diisopropylamide (KDA). Subsequent functionalization has been achieved with a wide range of electrophiles and good to excellent yields have been obtained. The action of other potassium or sodium bases has also been investigated. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00507-9

文献信息

• Transannular bond formation between the amino and the sulfonio groups in 6,7-dihydro-6-methyl-5H-dibenzo[b,g][1,5]thiazocinium salts. The first example of a sulfurane with an apical alkyl group
  作者：Kinya. Akiba、Kohichi. Takee、Yasuko. Shimizu、Katsuo. Ohkata

  DOI：10.1021/ja00280a033

  日期：1986.10
• On the metallation of 2-isopropylpyridine
  作者：Eric Pasquinet、Patrick Rocca、Francis Marsais、Alain Godard、Guy Quéguiner

  DOI：10.1016/s0040-4020(98)00507-9

  日期：1998.7

  2-Isopropylpyridine has been successfully metallated and functionalized by using potassium diisopropylamide (KDA). Subsequent functionalization has been achieved with a wide range of electrophiles and good to excellent yields have been obtained. The action of other potassium or sodium bases has also been investigated. (C) 1998 Elsevier Science Ltd. All rights reserved.

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