HT1147 | 67048-85-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: HT1147
• 英文别名: 5-(3,5-dimethoxy-phenyl)-[1,3,4]oxathiazol-2-one；5-(3',5'-dimethoxyphenyl-1,3,4-oxathiazol-2-on；5-(3,5-Dimethoxyphenyl)-1,3,4-oxathiazol-2-one
• CAS: 67048-85-5
• 化学式: C₁₀H₉NO₄S
• 分子量: 239.252
• InChiKey: OXPHVXMBHPWQOT-UHFFFAOYSA-N

物化性质

• 熔点：
  176-178 °C (decomp)
• 沸点：
  372.7±52.0 °C(Predicted)
• 密度：
  1.40±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  82.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  HT1147 以25%的产率得到
  参考文献：
  名称：

  HOWE R. K.; GRUNER T. A.; CARTER L. G.; BLAC L. L.; FRANZ J. E., J. ORG. CHEM., 1978, 43, NO 19, 3736-3742

  摘要：

  DOI：
• 作为产物：
  描述：

  3,5-二甲氧基苯甲酰胺 、 氯羰基亚磺酰氯 以 甲苯 为溶剂， 生成 HT1147
  参考文献：
  名称：

  Cycloaddition reactions of nitrile sulfides with acetylenic esters. Synthesis of isothiazolecarboxylates

  摘要：

  DOI：

  10.1021/jo00413a024

文献信息

• Nitrile sulfides. Synthesis of 1,2,4-thiadiazoles
  作者：Robert K. Howe、John E. Franz

  DOI：10.1021/jo00921a022

  日期：1974.4
• PROTEASOME INHIBITORS AND THEIR USE IN TREATING PATHOGEN INFECTION AND CANCER
  申请人：Nathan Carl

  公开号：US20110118274A1

  公开（公告）日：2011-05-19

  The present invention relates to proteasome inhibitors and their use in methods of treating a subject for a pathogen infection or cancer. The methods involve administering to the subject a compound of Formula (I). (I) where: Q is Formula or Formula, where the crossing dashed line illustrates the bond formed joining Q to the rest of the compound of Formula (I). The remainder of substituents of the compound of Formula (I) are defined in the present application.
• [EN] PROTEASOME INHIBITORS AND THEIR USE IN TREATING PATHOGEN INFECTION AND CANCER<br/>[FR] INHIBITEURS DE PROTÉASOME ET LEUR UTILISATION DANS LE TRAITEMENT D'UNE AFFECTION PATHOGÈNE ET DU CANCER
  申请人：CORNELL RES FOUNDATION INC

  公开号：WO2009026579A1

  公开（公告）日：2009-02-26

  The present invention relates to proteasome inhibitors and their use in methods of treating a subject for a pathogen infection or cancer. The methods involve administering to the subject a compound of Formula (I). (I) where: Q is Formula or Formula, where the crossing dashed line illustrates the bond formed joining Q to the rest of the compound of Formula (I). The remainder of substituents of the compound of Formula (I) are defined in the present application.
• Cycloaddition reactions of nitrile sulfides with acetylenic esters. Synthesis of isothiazolecarboxylates
  作者：Robert K. Howe、Terry A. Gruner、Linda G. Carter、Linda L. Black、John E. Franz

  DOI：10.1021/jo00413a024

  日期：1978.9
• HOWE R. K.; GRUNER T. A.; CARTER L. G.; BLAC L. L.; FRANZ J. E., J. ORG. CHEM., 1978, 43, NO 19, 3736-3742
  作者：HOWE R. K.、 GRUNER T. A.、 CARTER L. G.、 BLAC L. L.、 FRANZ J. E.

  DOI：——

  日期：——