1,2-dimethoxy-4bH-benzo[2,3]furo[3',4':5,6][1,4]diazepino[7,1-a]isoindole-5,14(7H,8H)-dione | 1313371-40-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 1,2-dimethoxy-4bH-benzo[2,3]furo[3',4':5,6][1,4]diazepino[7,1-a]isoindole-5,14(7H,8H)-dione
• 英文别名: 17,18-Dimethoxy-4-oxa-7,14-diazapentacyclo[12.7.0.02,6.08,13.016,21]henicosa-2(6),8,10,12,16(21),17,19-heptaene-3,15-dione；17,18-dimethoxy-4-oxa-7,14-diazapentacyclo[12.7.0.02,6.08,13.016,21]henicosa-2(6),8,10,12,16(21),17,19-heptaene-3,15-dione
• CAS: 1313371-40-2
• 化学式: C₂₀H₁₆N₂O₅
• 分子量: 364.357
• InChiKey: OVOFFOFZWGHMKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  77.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-羟乙酰乙酸内酯 、 2-羧基-3,4-二甲氧基苯甲醛 、 邻苯二胺 在 溶剂黄146 作用下， 以 水 为溶剂， 反应 0.44h， 以83%的产率得到1,2-dimethoxy-4bH-benzo[2,3]furo[3',4':5,6][1,4]diazepino[7,1-a]isoindole-5,14(7H,8H)-dione
  参考文献：
  名称：

  一种高效的三组分串联反应导致水中五环异吲哚稠合的苯并[b,e][1,4]二氮杂

  摘要：

  已开发出一种从水中易得的常见反应物合成高度官能化的五环异吲哚稠合苯并[b,e][1,4]二氮杂衍生物的有效方法...

  DOI：

  10.1246/cl.2011.834

文献信息

• Microwave-assisted multi-component reaction in water leading to highly regioselective formation of benzo[f]azulen-1-ones
  作者：Shu-Liang Wang、Chuang Cheng、Fei-Yue Wu、Bo Jiang、Feng Shi、Shu-Jiang Tu、Trideep Rajale、Guigen Li

  DOI：10.1016/j.tet.2011.05.002

  日期：2011.6

  Microwave-assisted three-component reaction has been established for the regioselective synthesis of benzo[f]azulen-1-ones. The reaction was performed in aqueous media under microwave irradiation by using readily available and inexpensive starting materials. A total of 38 examples were examined to show a broad substrate scope and good overall yields (70-89%). The present new synthesis shows attractive green chemistry characteristics, such as the use of water as reaction media, concise one-pot conditions, short reaction periods (7-24 min), easy work-up/purification, and reduced waste production without the use of any strong acids or metal promoters. (C) 2011 Elsevier Ltd. All rights reserved.
• An Efficient Three-component Tandem Reaction Leading to Pentacyclic Isoindole-fused Benzo[<i>b</i>,<i>e</i>][1,4]diazepines in Water
  作者：Shu-Liang Wang、Chuang Cheng、Fei-Yue Wu、Jing Li、Bo Jiang、Shu-Jiang Tu

  DOI：10.1246/cl.2011.834

  日期：2011.8.5

  An efficient methodology for the synthesis of highly functionalized pentacyclic isoindole-fused benzo[b,e][1,4]diazepine derivatives from readily available common reactants in water has been develo...

  已开发出一种从水中易得的常见反应物合成高度官能化的五环异吲哚稠合苯并[b,e][1,4]二氮杂衍生物的有效方法...