5-Hydroxy-1-methyl-5-phenyl-3-isopropyl-4-(isopropylimino)-2-thioxo-1,3-diazolidine | 138877-78-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5-Hydroxy-1-methyl-5-phenyl-3-isopropyl-4-(isopropylimino)-2-thioxo-1,3-diazolidine
• 英文别名: 4-Hydroxy-3-methyl-4-phenyl-1-propan-2-yl-5-propan-2-yliminoimidazolidine-2-thione
• CAS: 138877-78-8
• 化学式: C₁₆H₂₃N₃OS
• 分子量: 305.444
• InChiKey: ZVMRSPHQFCMEPP-UHFFFAOYSA-N

物化性质

• 沸点：
  416.2±55.0 °C(Predicted)
• 密度：
  1.14±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  71.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-Methyl-2-(methylthio)-5-phenyl-3-isopropyl-4-(isopropylamino)imidazolium chloride 在 air 作用下， 以 甲苯 为溶剂， 反应 1.0h， 以70%的产率得到5-Hydroxy-1-methyl-5-phenyl-3-isopropyl-4-(isopropylimino)-2-thioxo-1,3-diazolidine
  参考文献：
  名称：

  Three-component cyclocondensations. An efficient synthesis of 4-amino-2-(methylthio)imidazolium salts via the reaction of methyl chlorothioimidates with benzaldimines and isocyanides. Autoxidation of the imidazole derivatives

  摘要：

  Treatment of imino chlorosulfides 1 with a mixture of benzaldimine and isocyanide provides 4-aminoimidazolium chlorides 5. Presumably this reaction involves the N-imidoylbenzylideniminium chlorides 4 as transient intermediates. 1- and 3-tert-Butyl imidazolium salts 5 undergo fast isobutene elimination giving the corresponding imidazole and imidazoline hydrochlorides 10 and 13. Compounds 13 autoxidize to afford 5-hydroxy derivatives 14 under atmospheric oxygen. The structural assignment of 14 has been confirmed by X-ray diffraction analysis. Under similar conditions, treatment of ketimines 17 with methyl chlorothioimidate 1 and isocyanide gives 2-thioxodiazolidines 19.

  DOI：

  10.1021/jo00033a038

文献信息

• Three-component cyclocondensations. An efficient synthesis of 4-amino-2-(methylthio)imidazolium salts via the reaction of methyl chlorothioimidates with benzaldimines and isocyanides. Autoxidation of the imidazole derivatives
  作者：Yvelise Malvaut、Evelyne Marchand、Georges Morel

  DOI：10.1021/jo00033a038

  日期：1992.3

  Treatment of imino chlorosulfides 1 with a mixture of benzaldimine and isocyanide provides 4-aminoimidazolium chlorides 5. Presumably this reaction involves the N-imidoylbenzylideniminium chlorides 4 as transient intermediates. 1- and 3-tert-Butyl imidazolium salts 5 undergo fast isobutene elimination giving the corresponding imidazole and imidazoline hydrochlorides 10 and 13. Compounds 13 autoxidize to afford 5-hydroxy derivatives 14 under atmospheric oxygen. The structural assignment of 14 has been confirmed by X-ray diffraction analysis. Under similar conditions, treatment of ketimines 17 with methyl chlorothioimidate 1 and isocyanide gives 2-thioxodiazolidines 19.