N'-tert-butyl-N-benzoyl-N'-(2-chlorobenzoyl)hydrazine | 112226-58-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-tert-butyl-N-benzoyl-N'-(2-chlorobenzoyl)hydrazine
• 英文别名: N'-t-butyl-N-benzoyl-N'-(2-chlorobenzoyl)hydrazine；N'-benzoyl-N-tert-butyl-2-chlorobenzohydrazide
• CAS: 112226-58-1
• 化学式: C₁₈H₁₉ClN₂O₂
• 分子量: 330.814
• InChiKey: ZIXLQHZCSCBWFZ-UHFFFAOYSA-N

物化性质

• 熔点：
  161.5 °C
• 密度：
  1.205±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N'-tert-butyl-N-benzoyl-N'-(2-chlorobenzoyl)hydrazine 生成 2-benzoyl-3-tert-butyl 3-(o-chlorobenzoyl)carbazonitrile
  参考文献：
  名称：

  KAMESWARAN, VENKSTARAMAN;WRIGHT, DONALD P.;HERMAN, ROD A.

  摘要：

  DOI：
• 作为产物：
  描述：

  N'-tert-butyl-N-benzoylhydrazine 、 邻氯苯甲酰氯 在 sodium hydroxide 作用下， 以 乙醚 为溶剂， 反应 3.0h， 生成 N'-tert-butyl-N-benzoyl-N'-(2-chlorobenzoyl)hydrazine
  参考文献：
  名称：

  Quantitative structure-activity analysis of larvicidal 1-(substituted benzoyl)-2-benzoyl-1-tert-butylhydrazines againstChilo suppressalis

  摘要：

  AbstractThe larvicidal activity of a number of 1‐(substituted benzoyl)‐2‐benzoyl–1 ‐ten‐butylhydrazines against the rice stem borer (Chilo suppressalis Walk.) was measured. Variations in the activity were examined quantitatively using physico‐chemical substituent and molecular parameters and regression analysis. The results indicated that the molecular hydrophobicity and the electron‐withdrawing inductive/ field effect of ontho substituents are favourable to larvicidal activity. The bulkiness of substituents at the meta and para positions was unfavourable to activity, substitution at the para position being more unfavourable than that at the meta position in terms of van der Waals' volume. The 2,3–, 2,5‐ and 2,6‐disubstitution patterns were also unfavourable to activity. Reductions in larvicidal activity caused by the 2,6‐,‐ 2,3,5‐ and 2,3,4,5‐substitutions were greater than those induced by the 2,3‐ and 2,5‐disubstitutions. When the sum of contributions from favourable effects is greater than that from unfavourable effects, the larvicidal activity is expected to be superior to that of the unsubstituted compound.

  DOI：

  10.1002/ps.2780410210

文献信息

• Synthesis and insecticidal evaluation ofN-tert-butyl-N′-thio[O-(1-methylthioethylimino)-N″-methylcarbamate]-N,N′-diacylhydrazines
  作者：Jian Shang、Yuxiu Liu、Runqiu Huang、Fuchun Bi、Qingmin Wang

  DOI：10.1002/hc.20360

  日期：2007.8

  A series of novel N-tert-butyl-N′-thio[O-(1-methylthioethylimino)-N″-methylcarbamate]-N,N′-diacylhydrazines were synthesized by the reaction of chlorosulfenyl[O-(1-methylthioethylimino)-N-methylcarbamate] with N-tert-butyl-N,N′-diacylhydrazine in the presence of sodium hydride. The reaction of sulfur dichloride with O-(1-methylthioethylimino)-N-methylcarbamate (Methomyl) in the presence of pyridine

  通过氯磺基[O-(1-甲硫基乙亚氨基)-N”-甲基氨基甲酸酯]-N,N'-二酰基肼的反应合成了一系列新型N-叔丁基-N'-硫代[O-(1-甲硫基乙基亚氨基)-N”-甲基氨基甲酸酯]-N,N'-二酰基肼-N-甲基氨基甲酸酯]与 N-叔丁基-N,N'-二酰基肼在氢化钠存在下。首次报道了二氯化硫与O-(1-甲硫基乙基亚氨基)-N-甲基氨基甲酸酯(灭多威)在吡啶存在下反应生成氯磺基[O-(1-甲硫基乙基亚氨基)-N-甲基氨基甲酸酯]。N-叔丁基-N'-硫代[O-(1-甲硫基乙基亚氨基)-N″-甲基氨基甲酸酯]-N,N'-二苯甲酰肼的X射线单晶衍射表明母体化合物N-叔丁基-N ,N'-二苯甲酰肼和O-(1-甲硫基乙基亚氨基)-N-甲基氨基甲酸酯通过NSN谱带结合得到产物。评价了它们对东方粘虫和蚜虫的杀幼虫活性。它们都对东方粘虫表现出优异的杀幼虫活性，其中一些表现出比亲本二酰基肼更高的杀幼虫活性。毒性试验表明，该产品在较高浓度下对
• Synthesis and Insecticidal Evaluation of <i>N</i>-<i>tert-</i>Butyl-<i>N</i>′-thio[1-(6-chloro-3-pyridylmethyl)-2-nitroiminoimidazolidine]-<i>N</i>,<i>N</i>′-diacylhydrazines
  作者：Jian Shang、Ranfen Sun、Yongqiang Li、Runqiu Huang、Fuchun Bi、Qingmin Wang

  DOI：10.1021/jf903642s

  日期：2010.2.10

  novel N-tert-butyl-N′-thio[1-(6-chloro-3-pyridylmethyl)-2-nitroiminoimidazolidine]-N,N′-diacylhydrazines were synthesized by the reaction of chlorosulfenyl(N-tert-butyl-N,N′-diacylhydrazines) with 1-(6-chloro-3-pyridylmethyl)-2-nitroiminoimidazolidine (imidacloprid) in the presence of sodium hydride. Their larvicidal activities were evaluated. All of them exhibited insecticidal activities against Oriental

  一系列新颖ñ -叔丁基- ñ ' -硫代[1-（6-氯-3-吡啶甲基）-2- nitroiminoimidazolidine] - ñ，Ñ '-diacylhydrazines被chlorosulfenyl的反应，合成（ñ -叔在氢化钠存在下，将丁基-N，N'-二酰基肼与1-（6-氯-3-吡啶甲基）-2-硝基亚氨基咪唑烷（吡虫啉）。他们的杀幼虫活性进行了评估。它们都表现出对东方粘虫和豆蚜的杀虫活性。毒性试验表明，在较高浓度下（200 mg L -1）标题化合物可在2小时内杀死杀灭蚜虫的速度与亲代吡虫啉一样快，而在较低浓度（10 mg L -1）下，标题化合物可在治疗3天后诱发幼虫，异常和致死幼虫蜕变，例如母体二酰基肼。
• Method of controlling insects
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0630568A1

  公开（公告）日：1994-12-28

  The present invention is concerned with a method of controlling insects using an insecticidally effective amount of certain N'-substituted-N,N'-diacylhydrazines having the formula wherein: X is phenyl, 2-fluorophenyl, or phenyl or 2-fluorophenyl substituted at the 4-position with chloro, fluoro, iodo, methyl or ethyl; and Y is phenyl, 4-fluorophenyl, 2-chloro-4-fluorophenyl or phenyl substituted at the 2-position with chloro, bromo or iodo.

  本发明涉及一种使用杀虫有效量的某些 N'-取代-N,N'-二乙酰肼的方法，这些 N'-取代-N,N'-二乙酰肼的化学式为 其中 X 是苯基、2-氟苯基或在 4 位被氯、氟、碘、甲基或乙基取代的苯基或 2-氟苯基；以及 Y 是苯基、4-氟苯基、2-氯-4-氟苯基或在 2 位被氯、溴或碘取代的苯基。
• Insecticidal N'-substituted-N,N'-diacylhydrazines
  申请人：ROHM AND HAAS COMPANY

  公开号：EP0236618B1

  公开（公告）日：1991-02-27
• EP0245950B1
  申请人：——

  公开号：EP0245950B1

  公开（公告）日：1992-06-17