4-Ethyl-4-(hydroxymethyl)-2-oxazolidinone | 162632-59-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 4-Ethyl-4-(hydroxymethyl)-2-oxazolidinone
• 英文别名: 4-ethyl-4-hydroxymethyloxazolidin-2-one；(+/-)-4-Ethyl-4-(hydroxymethyl)-2-oxazolidinone；4-ethyl-4-hydroxymethyl-2-oxazolidinone；4-hydroxymethyl-4-ethyl-2-oxazolidinone；4-ethyl-4-hydroxymethyl-2-oxazolidone；4-ethyl-4-(hydroxymethyl)-1,3-oxazolidin-2-one
• CAS: 162632-59-9
• 化学式: C₆H₁₁NO₃
• 分子量: 145.158
• InChiKey: FCMBXDLFGKHPLS-UHFFFAOYSA-N

物化性质

• 沸点：
  371.1±11.0 °C(Predicted)
• 密度：
  1.144±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-甲基巴豆酰氯 、 4-Ethyl-4-(hydroxymethyl)-2-oxazolidinone 以 氯仿 为溶剂， 以90%的产率得到4-(3',3'-dimethylacryloxymethyl)-4-ethyl-2-oxazolidinone
  参考文献：
  名称：

  Surface active N-halamine compounds

  摘要：

  提供具有环状N-卤胺生物杀菌单体和聚合物的方法，并将其用作生物杀菌剂，其中功能性基团卤代噁唑烷酮可以同聚和共聚。共聚反应使用廉价单体，例如丙烯腈，苯乙烯，醋酸乙烯酯，氯乙烯等。还可以通过嫁接反应将N-卤胺单体与商业聚合物如聚丙烯腈，聚苯乙烯，聚醋酸乙烯，聚乙烯醇，聚氯乙烯和纤维素反应。这些N-卤胺化合物是稳定的生物杀菌剂，可以释放少量的自由卤素和其他杂质。它们将用作游泳池，油漆，防腐剂，医疗和牙科涂料，工业和商业涂料，织物，无菌绷带，容器衬里等的消毒剂。

  公开号：

  US05902818A1
• 作为产物：
  描述：

  2-氨基-2-乙基-1,3-丙二醇 在 氮气 、 尿素 作用下， 生成 4-Ethyl-4-(hydroxymethyl)-2-oxazolidinone
  参考文献：
  名称：

  Imidazolidone polyetheramine strength enhancing additives of epoxy resin

  摘要：

  该发明披露了咪唑烷酮改性聚醚胺的组成和制备方法。烷基聚醚胺来源于2-异丙基氨基乙胺和尿素。N-异丙基-2-咪唑烷酮是中间产物，经烷氧基化和胺化制备N-异丙基咪唑烷酮聚醚胺。该发明还披露了通过还原胺化从4-乙基-4-羟甲基-2-咪唑烷酮衍生的多元醇制备咪唑烷酮改性聚醚胺的组成和制备方法。该发明的产品在环氧树脂应用中经过测试，表现出改良的性能。这些产品也可能在聚脲应用中有用。

  公开号：

  US05422042A1

文献信息

• Ethyl Imidazole-1-carboxylate (EImC) as a Carbonylating Agent: Efficient Synthesis of Oxazolidin-2-ones from Amino Alcohols
  作者：S. Veeraswamy、K. Indrasena Reddy、R. Venkat Ragavan、Satyanarayana Yennam、A. Jayashree

  DOI：10.1246/cl.2013.109

  日期：2013.2.5

  Various substituted oxazolidin-2-ones were synthesized from the corresponding amino alcohols using ethyl imidazole-1-carboxylate (EImC). Highly substituted and sterically hindered amino alcohols and amino alcohols having a free hydroxy group were cyclized to oxazolidin-2-ones efficiently. This method is simple and produces oxazolidin-2-ones in very good yield.

  从相应的氨基醇合成了多种取代的噁唑烷-2-酮，使用了乙基咪唑-1-羧酸酯（EImC）。高度取代且空间位阻的氨基醇以及具有自由羟基的氨基醇均能高效环化为噁唑烷-2-酮。该方法简单，并能以非常好的产率生产噁唑烷-2-酮。
• Surface active N-Halamine compounds
  申请人：Auburn University

  公开号：US06469177B1

  公开（公告）日：2002-10-22

  N-halamine biocidal materials and coatings are provided. Monomeric oxazolidinones or hydantoins are homopolymerized or copolymerized with other monomers so as to produce materials or coatings, which upon exposure to solutions of chlorine or bromine become biocidal. The biocidal materials and coatings are effective at inactivating microorganisms upon surface contact and are regenerable following loss of efficacy upon further exposure to solutions of chlorine or bromine. Surfaces which could be treated with the materials and coatings include, but are not limited to: glass, plastic, metals, fibers, and wood for use in pool and tank liners, food wrappers, catheters, paints, tiles, shower walls, fabrics, sterile bandages, pipes, medical and dental coatings, preservatives, and the like.

  提供了N-卤胺生物杀菌材料和涂层。单体的噁唑烷酮或海达因酮与其他单体共聚或均聚，以产生在暴露于氯或溴溶液后具有生物杀菌作用的材料或涂层。这些生物杀菌材料和涂层在表面接触时有效地灭活微生物，并在进一步暴露于氯或溴溶液后失去效力时可再生。可以用这些材料和涂层处理的表面包括但不限于：玻璃、塑料、金属、纤维和木材，用于游泳池和储罐衬里、食品包装、导管、油漆、瓷砖、淋浴墙、织物、无菌绷带、管道、医疗和牙科涂层、防腐剂等。
• Hypolipidaemic condensed 1,4-thiazepines
  申请人：Glaxo Wellcome Inc.

  公开号：US05817652A1

  公开（公告）日：1998-10-06

  The invention provides a compound of formula (I), wherein n is an integer of from 0 to 2; R is an optional substituent; R.sup.1 is hydrogen or C.sub.1-6 alkyl; R.sup.2 is an atom or group selected from hydrogen, C.sub.1-4 alkyl (including cycloalkyl and cycloalkylalkyl), C.sub.1-4 alkoxy, pyrryl, thienyl, pyridyl, 1,3-benzodioxolo, phenyl and naphthyl, which groups are optionally substituted; R.sup.3 is hydrogen, OH, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or --O C.sub.1-6 acyl; R.sup.4 is a group independently selected from C.sub.1-6 alkyl (including cycloalkyl and cycloalkylalkyl), C.sub.2-6 alkenyl, and C.sub.2-6 -alkynyl which groups are optionally substituted; R.sup.5 is a group independently selected from C.sub.2-6 alkyl (including cycloalkyl and cycloalkylalkyl), C.sub.2-6 alkenyl and C.sub.2-6 alkynyl, which groups are optionally substituted; or R.sup.4 and R.sup.5, together with the carbon atom to which they are attached, form a C.sub.3-7 spiro cycloalkyl group which is optionally substituted; R.sup.6 and R.sup.7 are independently selected from hydrogen and C.sub.1-6 alkyl; and X is an aromatic or non-aromatic monocyclic or bicyclic ring system having from 5 to 10 carbon atoms (including the two carbon atoms forming part of the thiazepine ring) wherein optionally one or more of the carbon atoms is/are replaced by heteroatom(s) independently selected from nitrogen, oxygen and sulphur, or X is an aromatic or non-aromatic monocyclic or bicyclic ring system having from 5 to 10 carbon atoms (including the two carbon atoms forming part of the thiazepine ring) wherein one or more of the carbon atoms is/are replaced by heteroatom(s) independently selected from nitrogen, oxygen and sulphur; and salts, solvates and physiologically functional derivatives thereof, pharmaceutical formulations comprising such compounds, processes for their preparation and their use in reducing bile acid uptake and hence as hypolipidaemic compounds. ##STR1##

  本发明提供了一种化合物，其化学式为（I），其中n是0到2的整数；R是可选的取代基；R.sup.1是氢或C.sub.1-6烷基；R.sup.2是从氢，C.sub.1-4烷基（包括环烷基和环烷基烷基），C.sub.1-4烷氧基，吡咯基，噻吩基，吡啶基，1,3-苯并二氧杂环，苯基和萘基中选择的原子或基团，这些基团可以被取代；R.sup.3是氢，OH，C.sub.1-6烷基，C.sub.1-6烷氧基或--O C.sub.1-6酰基；R.sup.4是从C.sub.1-6烷基（包括环烷基和环烷基烷基），C.sub.2-6烯基和C.sub.2-6-炔基中独立选择的基团，这些基团可以被取代；R.sup.5是从C.sub.2-6烷基（包括环烷基和环烷基烷基），C.sub.2-6烯基和C.sub.2-6炔基中独立选择的基团，这些基团可以被取代；或R.sup.4和R.sup.5与它们连接的碳原子一起形成一个C.sub.3-7螺环烷基团，该基团可以被取代；R.sup.6和R.sup.7独立选择自氢和C.sub.1-6烷基；X是具有5到10个碳原子（包括构成噻唑环一部分的两个碳原子）的芳香或非芳香单环或双环环系，其中可选地一个或多个碳原子被氮，氧和硫独立选择的杂原子替换，或者X是具有从5到10个碳原子（包括构成噻唑环一部分的两个碳原子）的芳香或非芳香单环或双环环系，其中一个或多个碳原子被氮，氧和硫独立选择的杂原子替换；以及这些化合物的盐，溶剂化合物和生理功能衍生物，包括这样的化合物的制药组合物，它们的制备过程以及它们在减少胆汁酸吸收和因此作为降脂化合物的用途。
• Ophthalmic devices containing heterocyclic compounds and methods for their production
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：EP1327893A1

  公开（公告）日：2003-07-16

  This invention relates to ophthalmic devices and methods for their production where the ophthalmic device contain a polymer and at least one heterocyclic compound comprising at least one N-Cl and/or N-Br bond.

  本发明涉及眼科设备及其生产方法，其中眼科设备包含聚合物和至少一种杂环化合物，杂环化合物包含至少一个 N-Cl 和/或 N-Br 键。
• Biocidal polyester and methods
  申请人：Auburn University

  公开号：US20030064645A1

  公开（公告）日：2003-04-03

  Biocidal polyester fabrics, fibers and other materials, and methods of preparation. Heterocyclic N-halamine precursor moieties are covalently linked to the polyester material. The fabrics or fibers obtain antimicrobial activity after washing with a source of oxidative halogen such as a chlorine bleach by conversion of the precursor moieties into N-halamine functionalities. The antimicrobial activity can be repeatedly regenerated by further washing with aqueous oxidative halogen. The biocidal polyester fabrics, fibers, and other materials will be effective in reducing, or eliminating entirely, pathogenic and odor-causing microorganisms.

  杀菌聚酯织物、纤维和其他材料及其制备方法。杂环 N-卤胺前体分子与聚酯材料共价连接。通过将前体分子转化为 N-卤胺官能团，在使用氯漂白剂等氧化卤源洗涤后，织物或纤维可获得抗菌活性。抗菌活性可通过进一步使用氧化卤素水溶液洗涤反复再生。这种杀菌聚酯织物、纤维和其他材料可有效减少或完全消除致病和致臭微生物。