(5S)-5-(hydroxymethyl)-3-methyl-1,3-oxazolidin-2-one | 637343-86-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (5S)-5-(hydroxymethyl)-3-methyl-1,3-oxazolidin-2-one
• 英文别名: (S)-5-(hydroxymethyl)-3-methyloxazolidin-2-one
• CAS: 637343-86-3
• 化学式: C₅H₉NO₃
• 分子量: 131.131
• InChiKey: NOGODPXRSZBASZ-BYPYZUCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  (5S)-5-(hydroxymethyl)-3-methyl-1,3-oxazolidin-2-one 以 吡啶 为溶剂， 生成 (R)-5-{[Benzyl-(3,4-difluoro-benzyl)-amino]-methyl}-3-methyl-oxazolidin-2-one
  参考文献：
  名称：

  Synthesis and antibacterial activities of chiral 1,3-oxazinan-2-one derivatives

  摘要：

  We report here the design, synthesis, and antibacterial activities of novel classes of compounds containing chiral 1,3-oxazinan-2-ones and oxazolidinones as the basic Core Structures. These compounds are tertiary amines containing the core structures and two aryl substituents. Several of these molecules exhibit potent antibacterial activities against the tested Gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Bacillus subtilis. These compounds represent new structure scaffolds and can be further optimized to give new antibacterial agents with structures significantly different from those of existing classes of antibiotics. (C) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.01.072
• 作为产物：
  描述：

  (S)-3-methyl-5-(trityloxymethyl)oxazolidin-2-one 在 三氟乙酸 作用下， 生成 (5S)-5-(hydroxymethyl)-3-methyl-1,3-oxazolidin-2-one
  参考文献：
  名称：

  Synthesis and antibacterial activities of chiral 1,3-oxazinan-2-one derivatives

  摘要：

  We report here the design, synthesis, and antibacterial activities of novel classes of compounds containing chiral 1,3-oxazinan-2-ones and oxazolidinones as the basic Core Structures. These compounds are tertiary amines containing the core structures and two aryl substituents. Several of these molecules exhibit potent antibacterial activities against the tested Gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Bacillus subtilis. These compounds represent new structure scaffolds and can be further optimized to give new antibacterial agents with structures significantly different from those of existing classes of antibiotics. (C) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.01.072

文献信息

• [EN] 1,3-THIAZOL-2-YL SUBSTITUTED BENZAMIDES<br/>[FR] BENZAMIDES À SUBSTITUTION 1,3-THIAZOL-2-YL
  申请人：EVOTEC AG

  公开号：WO2016091776A1

  公开（公告）日：2016-06-16

  The present invention relates to 1,3-thiazol-2-yl substituted benzamide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.

  本发明涉及一般式（I）所述和定义的1,3-噻唑-2-基取代苯甲酰胺化合物，以及包含所述化合物的药物组合物和药物组合物的用途，用于制造用于治疗或预防疾病的药物组合物，特别是神经源性疾病，作为唯一药剂或与其他活性成分组合使用。
• [EN] ARYL FORMAMIDE COMPOUND, PREPARATION METHOD FOR SAME, AND MEDICINAL USES THEREOF<br/>[FR] COMPOSÉ ARYL FORMAMIDE, SON PROCÉDÉ DE PRÉPARATION ET SES UTILISATIONS MÉDICALES<br/>[ZH] 芳基甲酰胺类化合物及其制备方法和医药用途
  申请人：THE NAT INSTITUTES OF PHARMACEUTICAL R&D CO LTD

  公开号：WO2022063205A8

  公开（公告）日：2023-03-30
• Synthesis and antibacterial activities of chiral 1,3-oxazinan-2-one derivatives
  作者：Guijun Wang、Jean-Rene Ella-Menye、Vibha Sharma

  DOI：10.1016/j.bmcl.2006.01.072

  日期：2006.4

  We report here the design, synthesis, and antibacterial activities of novel classes of compounds containing chiral 1,3-oxazinan-2-ones and oxazolidinones as the basic Core Structures. These compounds are tertiary amines containing the core structures and two aryl substituents. Several of these molecules exhibit potent antibacterial activities against the tested Gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Bacillus subtilis. These compounds represent new structure scaffolds and can be further optimized to give new antibacterial agents with structures significantly different from those of existing classes of antibiotics. (C) 2006 Elsevier Ltd. All rights reserved.