ebeiedine | 25650-70-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: ebeiedine
• 英文别名: ebeinine；(1R,2S,6S,9S,10R,11S,14S,15S,17R,18S,20S,23R,24S)-6,10,23-trimethyl-4-azahexacyclo[12.11.0.02,11.04,9.015,24.018,23]pentacosane-17,20-diol
• CAS: 25650-70-8
• 化学式: C₂₇H₄₅NO₂
• 分子量: 415.66
• InChiKey: NEMWYOKGHGSVSC-DZYYLIMLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  30
• 可旋转键数：
  0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ebeiedine 、 1-萘甲酰氯 在 氯化亚砜 作用下， 以 乙腈 为溶剂， 反应 2.0h， 以96.75%的产率得到ebeiedine 3β,6β-bis(1-naphthoate)
  参考文献：
  名称：

  Prederivatization and High-Performance Liquid Chromatographic Analysis of Alkaloids of Bulbs of Fritillaria

  摘要：

  A method of prederivatization and HPLC with UV detection was developed for the simultaneous analysis of five major steroidal alkaloids of the Fritillaria species: verticine, verticinone, isoverticine, ebeiedine, and ebeiedinone. Derivatization was carried out by esterification of the hydroxyl-containing Fritillaria alkaloids to the corresponding naphthoates with 1-naphthoyl chloride. Reaction conditions were optimized and the yields of the derivatization were between 94 and 100% for all test alkaloids. Derivatized alkaloids were characterized by mass spectrometry and HPLC-MS. The validated HPLC-UV method demonstrated linear UV response at the sampling ranges used, and a test limit of 1 mu g/mL was determined for all analytes. This analytical method is simple, convenient, and readily reproducible. The developed method was applied to the analysis of the major pharmacologically active alkaloids in three medicinally used Fritillaria species: F. cirrhosa F. thunberghii, and F. hupehensis. Five major Fritillaria alkaloids were simultaneously analyzed qualitatively and quantitatively from crude extracts of each of these herbs.

  DOI：

  10.1021/js960211v
• 作为产物：
  描述：

  乙酸酐 、 ebeiedinone 在 sodium tetrahydroborate 作用下， 以 吡啶 为溶剂， 生成 ebeiedine
  参考文献：
  名称：

  Lee, Ping; Kitamura, Yukie; Kaneko, Koh, Chemical and pharmaceutical bulletin, 1988, vol. 36, # 11, p. 4316 - 4329

  摘要：

  DOI：

文献信息

• Prederivatization and High-Performance Liquid Chromatographic Analysis of Alkaloids of Bulbs of Fritillaria
  作者：Kan Ding、Ge Lin、Yee-Ping Ho、Tin Y Cheng、Ping Li

  DOI：10.1021/js960211v

  日期：1996.11

  A method of prederivatization and HPLC with UV detection was developed for the simultaneous analysis of five major steroidal alkaloids of the Fritillaria species: verticine, verticinone, isoverticine, ebeiedine, and ebeiedinone. Derivatization was carried out by esterification of the hydroxyl-containing Fritillaria alkaloids to the corresponding naphthoates with 1-naphthoyl chloride. Reaction conditions were optimized and the yields of the derivatization were between 94 and 100% for all test alkaloids. Derivatized alkaloids were characterized by mass spectrometry and HPLC-MS. The validated HPLC-UV method demonstrated linear UV response at the sampling ranges used, and a test limit of 1 mu g/mL was determined for all analytes. This analytical method is simple, convenient, and readily reproducible. The developed method was applied to the analysis of the major pharmacologically active alkaloids in three medicinally used Fritillaria species: F. cirrhosa F. thunberghii, and F. hupehensis. Five major Fritillaria alkaloids were simultaneously analyzed qualitatively and quantitatively from crude extracts of each of these herbs.
• Lee, Ping; Kitamura, Yukie; Kaneko, Koh, Chemical and pharmaceutical bulletin, 1988, vol. 36, # 11, p. 4316 - 4329
  作者：Lee, Ping、Kitamura, Yukie、Kaneko, Koh、Shiro, Motoo、Xu, Guo-Jun、et al.

  DOI：——

  日期：——