N-(diphenylmethylene)glycine di(tert-butyl)methyl ester | 1147129-41-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(diphenylmethylene)glycine di(tert-butyl)methyl ester
• 英文别名: 2,2,4,4-Tetramethylpentan-3-yl 2-(benzhydrylideneamino)acetate
• CAS: 1147129-41-6
• 化学式: C₂₄H₃₁NO₂
• 分子量: 365.516
• InChiKey: DTGBZTYNRSLAIY-UHFFFAOYSA-N

物化性质

• 沸点：
  435.3±37.0 °C(predicted)
• 密度：
  0.97±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-戊烯-3-酮 、 N-(diphenylmethylene)glycine di(tert-butyl)methyl ester 在 C₆₂H₃₆F₁₂NO⁽¹⁺⁾*Br^(1-) 、 cesium chloride 、 potassium carbonate 作用下， 以 乙醚 为溶剂， 反应 6.0h， 以84%的产率得到2,2,4,4-tetramethylpentan-3-yl (2R)-2-(benzhydrylideneamino)-5-oxoheptanoate
  参考文献：
  名称：

  Organocatalytic Approach to Enantioselective One-Pot Synthesis of Pyrrolidine, Hexahydropyrrolizine, and Octahydroindolizine Core Structures

  摘要：

  An enantioselective organocatalytic, one-pot synthesis of pyrrolidine, hexahydropyrrolizine, and octahydroindolizine core structures was realized starting from readily available glycine esters by combination with several different organocatalytic reactions.

  DOI：

  10.1021/ol900477x
• 作为产物：
  描述：

  二苯甲酮亚胺 、 2,2,4,4-tetramethylpentan-3-yl 2-bromoacetate 在 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 以4.6 g的产率得到N-(diphenylmethylene)glycine di(tert-butyl)methyl ester
  参考文献：
  名称：

  Rate Enhancement of Phase Transfer Catalyzed Conjugate Additions by CsCl

  摘要：

  A rate enhancement of phase transfer catalyzed conjugate additions was accomplished using a catalytic amount of CsCl. The utility of this method was demonstrated in the asymmetric synthesis of glutamic acid derivatives by using a chiral phase transfer catalyst.

  DOI：

  10.1021/ol900476e

文献信息

• Rate Enhancement of Phase Transfer Catalyzed Conjugate Additions by CsCl
  作者：Taichi Kano、Takeshi Kumano、Keiji Maruoka

  DOI：10.1021/ol900476e

  日期：2009.5.7

  A rate enhancement of phase transfer catalyzed conjugate additions was accomplished using a catalytic amount of CsCl. The utility of this method was demonstrated in the asymmetric synthesis of glutamic acid derivatives by using a chiral phase transfer catalyst.
• Organocatalytic Approach to Enantioselective One-Pot Synthesis of Pyrrolidine, Hexahydropyrrolizine, and Octahydroindolizine Core Structures
  作者：Yong-Gang Wang、Takeshi Kumano、Taichi Kano、Keiji Maruoka

  DOI：10.1021/ol900477x

  日期：2009.5.7

  An enantioselective organocatalytic, one-pot synthesis of pyrrolidine, hexahydropyrrolizine, and octahydroindolizine core structures was realized starting from readily available glycine esters by combination with several different organocatalytic reactions.