diethyl 1-(2-nitrophenyl)ethyl phosphate | 150943-30-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diethyl 1-(2-nitrophenyl)ethyl phosphate
• CAS: 150943-30-9
• 化学式: C₁₂H₁₈NO₆P
• 分子量: 303.252
• InChiKey: ITBOHBYLFBJXSV-UHFFFAOYSA-N

物化性质

• 沸点：
  408.6±28.0 °C(Predicted)
• 密度：
  1.242±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  90.6
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  磷酸二乙酯 、 1-(1-溴乙基)-2-硝基苯 在 silver(l) oxide 作用下， 以 乙腈 为溶剂， 反应 4.5h， 以80%的产率得到diethyl 1-(2-nitrophenyl)ethyl phosphate
  参考文献：
  名称：

  Furuta, Toshiaki; Torigai, Hiromi; Osawa, Tomoko, Journal of the Chemical Society. Perkin transactions I, 1993, # 24, p. 3139 - 3142

  摘要：

  DOI：

文献信息

• Photocleavage of o-nitrobenzyl ether derivatives for rapid biomedical release applications
  作者：Moon Suk Kim、Scott L. Diamond

  DOI：10.1016/j.bmcl.2006.05.013

  日期：2006.8

  The externally controlled cleavage of covalently linked prodrugs, proteins, or solid-phase formulation vehicles offers potential advantages for controlled drug or gene delivery. A series of o-nitrobenzyl ester compounds (1 8) were synthesized to allow a systematic study of photolability. The o-nitrobenzyl ester was strictly required for photolability, while imido esters were not photolabile. The degradation kinetics of 1-o-phenylethyl ester was an order of magnitude faster than that of o-nitrobenzyl ester. Tosylate, phosphate, and benzoate derivatives of 1-o-nitrophenylethyl displayed similar photolability (> 80% decomposition within 10 min at 3.5 mW/cm(2) at 365 nm). O-o-Nitrobenzyl O'O"-diethyl phosphate displayed the fastest decomposition at photoirradiation condition (3.5 mW/cm(2), 365 nm) suitable for biological systems. We report the synthesis and photo-decomposition of 1-o-nitrophenylethyl derivatives amenable for the creation of photolabile prodrugs or formulation particles for drug depots, DNA condensation, or tissue engineering applications. (c) 2006 Elsevier Ltd. All rights reserved.
• Furuta, Toshiaki; Torigai, Hiromi; Osawa, Tomoko, Journal of the Chemical Society. Perkin transactions I, 1993, # 24, p. 3139 - 3142
  作者：Furuta, Toshiaki、Torigai, Hiromi、Osawa, Tomoko、Iwamura, Michiko

  DOI：——

  日期：——