(S)-ethyl 3-ethoxy-4-(1-hydroxy-2-oxoazetidin-3-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxylate | 1448995-16-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: (S)-ethyl 3-ethoxy-4-(1-hydroxy-2-oxoazetidin-3-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxylate
• 英文别名: ethyl 3-ethoxy-4-[(3S)-1-hydroxy-2-oxoazetidin-3-yl]-5-oxo-1,2,4-triazole-1-carboxylate
• CAS: 1448995-16-1
• 化学式: C₁₀H₁₄N₄O₆
• 分子量: 286.244
• InChiKey: HUGRQJRRYMBXDZ-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  、 偶氮二甲酸二乙酯 在 三苯基膦 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 (S)-ethyl 3-ethoxy-4-(1-hydroxy-2-oxoazetidin-3-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazole-1-carboxylate
  参考文献：
  名称：

  Teaching old dogs (Fmoc-amine, azodicarboxylate, and phosphine) new tricks (triazolinones)

  摘要：

  Exposure of Fmoc-amines to an excess of standard Mitsunobu reagents, azodicarboxylate and triphenylphosphine, at ambient temperature yielded triazolinone derivatives in high yield and purity. This transformation appeared to be general and the traditional Mitsunobu reaction can be carried out independently of triazolinone formation because the latter requires a high excess of reagents. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.06.115

文献信息

• Teaching old dogs (Fmoc-amine, azodicarboxylate, and phosphine) new tricks (triazolinones)
  作者：Anna Krchňáková、Patricia A. Miller、Marvin J. Miller、Viktor Krchňák

  DOI：10.1016/j.tetlet.2013.06.115

  日期：2013.8

  Exposure of Fmoc-amines to an excess of standard Mitsunobu reagents, azodicarboxylate and triphenylphosphine, at ambient temperature yielded triazolinone derivatives in high yield and purity. This transformation appeared to be general and the traditional Mitsunobu reaction can be carried out independently of triazolinone formation because the latter requires a high excess of reagents. (C) 2013 Elsevier Ltd. All rights reserved.