7-amino-3-ethylthiazolo[4,5-d]pyrimidin-2(3H)-thione | 1188448-35-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 7-amino-3-ethylthiazolo[4,5-d]pyrimidin-2(3H)-thione
• 英文别名: 7-Amino-3-ethyl-[1,3]thiazolo[4,5-d]pyrimidine-2-thione
• CAS: 1188448-35-2
• 化学式: C₇H₈N₄S₂
• 分子量: 212.299
• InChiKey: QXNZEBGBCXEYHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  112
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  7-amino-3-ethylthiazolo[4,5-d]pyrimidin-2(3H)-thione 、 异氰酸2-甲氧苯酯 以 乙腈 为溶剂， 以82%的产率得到1-(3-ethyl-2-thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidin-7-yl)-3-(2-methoxyphenyl)thiourea
  参考文献：
  名称：

  Synthesis of some urea and thiourea derivatives of 3-phenyl/ethyl-2-thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidine and their antagonistic effects on haloperidol-induced catalepsy and oxidative stress in mice

  摘要：

  A series of 3-phenyl/ethyl-2-thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidin-7-yl urea and thiourea derivatives were designed and synthesized. All the compounds have been evaluated for their anti parkinsonian activity in catalepsy induced by haloperidol in mice. A majority of the compounds exhibited significant anti parkinsonian activity after intraperitoneal administration. The most active compound carries methoxy group at 2-position of the phenyl ring. Some of the potent compounds were selected for biochemical estimations of malondialdehyde, glutathione, superoxide dismutase and glutathione peroxidase from brain homogenate to highlight the neuroprotective properties associated with them. The results obtained in the present study may lead to the development of a suitable approach to the treatment of Parkinson's disease and may be the starting point for the future drug design. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.04.007
• 作为产物：
  描述：

  4-amino-3-ethyl-2,3-dihydro-2-thioxo-1,3-thiazole-5-carbonitrile 、 formamide 在 甲酸 、 水 作用下， 反应 6.0h， 以64%的产率得到7-amino-3-ethylthiazolo[4,5-d]pyrimidin-2(3H)-thione
  参考文献：
  名称：

  Synthesis of some urea and thiourea derivatives of 3-phenyl/ethyl-2-thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidine and their antagonistic effects on haloperidol-induced catalepsy and oxidative stress in mice

  摘要：

  A series of 3-phenyl/ethyl-2-thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidin-7-yl urea and thiourea derivatives were designed and synthesized. All the compounds have been evaluated for their anti parkinsonian activity in catalepsy induced by haloperidol in mice. A majority of the compounds exhibited significant anti parkinsonian activity after intraperitoneal administration. The most active compound carries methoxy group at 2-position of the phenyl ring. Some of the potent compounds were selected for biochemical estimations of malondialdehyde, glutathione, superoxide dismutase and glutathione peroxidase from brain homogenate to highlight the neuroprotective properties associated with them. The results obtained in the present study may lead to the development of a suitable approach to the treatment of Parkinson's disease and may be the starting point for the future drug design. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.04.007

文献信息

• Synthesis of some urea and thiourea derivatives of 3-phenyl/ethyl-2-thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidine and their antagonistic effects on haloperidol-induced catalepsy and oxidative stress in mice
  作者：Faizul Azam、Ismail A. Alkskas、Musa A. Ahmed

  DOI：10.1016/j.ejmech.2009.04.007

  日期：2009.10

  A series of 3-phenyl/ethyl-2-thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidin-7-yl urea and thiourea derivatives were designed and synthesized. All the compounds have been evaluated for their anti parkinsonian activity in catalepsy induced by haloperidol in mice. A majority of the compounds exhibited significant anti parkinsonian activity after intraperitoneal administration. The most active compound carries methoxy group at 2-position of the phenyl ring. Some of the potent compounds were selected for biochemical estimations of malondialdehyde, glutathione, superoxide dismutase and glutathione peroxidase from brain homogenate to highlight the neuroprotective properties associated with them. The results obtained in the present study may lead to the development of a suitable approach to the treatment of Parkinson's disease and may be the starting point for the future drug design. (C) 2009 Elsevier Masson SAS. All rights reserved.