7-methoxy-3-(6'-methoxy-1',2',3',4',-tetrahydronaphth-1'-yl)-1,2-dihydronaphthalene | 16821-33-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 7-methoxy-3-(6'-methoxy-1',2',3',4',-tetrahydronaphth-1'-yl)-1,2-dihydronaphthalene
• 英文别名: 7-methoxy-3-(6-methoxy-1,2,3,4-tetrahydronaphthyl)-1,2-dihydronaphthalene；6,6'-Dimethoxy-1,2,3,4,3',4'-hexahydro-[1,2']binaphthyl；6,6'-Dimethoxy-1,2,3,3',4,4'-hexahydro-1,2'-binaphthyl；7-methoxy-3-(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-1,2-dihydronaphthalene
• CAS: 16821-33-3
• 化学式: C₂₂H₂₄O₂
• 分子量: 320.431
• InChiKey: LQIYWRYUYNEUAP-UHFFFAOYSA-N

物化性质

• 熔点：
  76-77 °C
• 沸点：
  233-238 °C(Press: 3 Torr)
• 密度：
  1.122±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  过氧化氢苯甲酰 、 氯仿 、 7-methoxy-3-(6'-methoxy-1',2',3',4',-tetrahydronaphth-1'-yl)-1,2-dihydronaphthalene 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  The Dimerization of 6-Methoxy-3,4-dihydronaphthalene

  摘要：

  DOI：

  10.1021/ja01233a003
• 作为产物：
  描述：

  1,2-二氢-7-甲氧基萘 在 氢溴酸 作用下， 生成 7-methoxy-3-(6'-methoxy-1',2',3',4',-tetrahydronaphth-1'-yl)-1,2-dihydronaphthalene
  参考文献：
  名称：

  A Glucomannan and Chitosan Fiber Supplement Decreases Plasma Cholesterol and Increases Cholesterol Excretion in Overweight Normocholesterolemic Humans

  摘要：

  Objective: Both chitosan and glucomannan have demonstrated hypocholesterolemic effects. A recent study in rats indicates that the combination of the two is also a potent hypocholesterolemic agent that increases fecal fat excretion. The objective of the present study was to determine the hypocholesterolemic effect of a supplement containing equal amounts of chitosan and glucomannan on blood lipid concentrations and fecal excretion of fat, neutral sterols and bile acids.Methods: Twenty-one overweight normocholesterolemic subjects (I I males and 10 females) were fed 2.4 g/day of a supplement containing equal amounts of chitosan and glucomannan. Prior to taking the supplement (initial period) and after 28 days (final period), blood was drawn for measurement of serum lipids and a three-day fecal sample collected for determination of fat, neutral sterol and bile acid excretion. Subjects maintained their normal dietary and activity patterns during the study.Results: Caloric intake and intake of fat and dietary fiber (excluding the supplement) did not differ between the initial and final periods. Serum total, HDL and LDL cholesterol concentrations were significantly lower (P < 0.05) in the final period compared to the initial period. Serum triacylglycerol concentration did not change between periods. There was a trend towards greater fecal excretion of neutral sterols and bile acids (p = 0.13 and 0.16, respectively) in the final period. However. fecal fat excretion did not differ between periods.Conclusions: Serum cholesterol reduction by a chitosan/glucomannan supplement is likely mediated by increased fecal steroid excretion and is not linked to fat excretion.

  DOI：

  10.1080/07315724.2002.10719246

文献信息

• Synthesis of 5-Alkylidene-6-(dimethylamino)methyl-1,3-cyclohexadienes from α-Substituted Benzyldimethylammoniomethylides
  作者：Yoshio Machida、Naohiro Shirai、Yoshiro Sato

  DOI：10.1055/s-1991-26393

  日期：——

  2-Substituted 5-alkylidene-6-(dimethylamino)methyl-1,3-cyclohexadienes (E)-4 and (Z)-4 were prepared by the reaction of α,4-disubstituted dimethyl[(trimethylsilyl)methyl]benzylammonium iodides 2 with cesium fluoride. Their E-isomers were stable at room temperature and could be used in the Diels-Alder reaction. Some related reactions are also described.

  通过铯氟化物与α,4-二取代的二甲基[(三甲基硅基)甲基]苄基铵碘化物的反应，制备了2-取代的5-烷叉基-6-(二甲基氨基)甲基-1,3-环己二烯（E）-4和（Z）-4。其E-异构体在室温下稳定，并可用于Diels-Alder反应。同时，还描述了一些相关的反应。
• Acid Catalysed Reaction of Indanones, Tetralones and Benzosuberone with Neopentyl Glycol and other Alkanediols under Forced Conditions
  作者：Masao Imai、Goreti Ribeiro Morais、Bassam al-Hindawi、Mazen A. M. al-Sulaibi、Mohammad Meetani、Thies Thiemann

  DOI：10.3184/030823410x12753214605445

  日期：2010.6

  Upon reaction with an excess of 2,2-dimethylpropane-1,3-diol (neopentyl glycol, NPG) under acid catalysis, indanones and tetralones yield indenes and dihydronaphthalenes, respectively. The reaction can also be carried out with butane-1,3-diol.

  在酸催化下与过量的 2,2-二甲基丙烷-1,3-二醇（新戊二醇，NPG）反应后，茚酮和四氢萘酮分别生成茚和二氢萘。该反应也可以用丁烷-1,3-二醇进行。
• STRUCTURAL MODELS OF CORTIN COMPOUNDS IN THE NAPHTHALENE SERIES
  作者：LOUIS LONG、ALFRED BURGER

  DOI：10.1021/jo01206a010

  日期：1941.11
• Controlling benzylic functionality and stereochemistry: 2. Synthesis of the pseudopterosin aglycone
  作者：Stuart W. McCombie、Brian Cox、Ashit K. Ganduly

  DOI：10.1016/s0040-4039(00)71243-3

  日期：1991.5

  Homologation, cyclisation, and reduction converted the tetralin (2) to the hexahydrophenalenol (8), which was methylated to afford (19) via alkoxide-directed metalation. The degree of stereoselectivity resulting from reactions of (19) and congeners with allylsilane - Lewis acid combinations was markedly dependent upon substitution patterns, whereas Et2AlCN-SnCl4 produced pseudoaxial nitriles. The trimethyl nitrile (24) was elaborated to the pseudopterosin aglycone (4).
• A Glucomannan and Chitosan Fiber Supplement Decreases Plasma Cholesterol and Increases Cholesterol Excretion in Overweight Normocholesterolemic Humans
  作者：Daniel D. Gallaher、Cynthia M. Gallaher、Gregory J. Mahrt、Timothy P. Carr、Carolyn H. Hollingshead、Robert Hesslink、John Wise

  DOI：10.1080/07315724.2002.10719246

  日期：2002.10

  Objective: Both chitosan and glucomannan have demonstrated hypocholesterolemic effects. A recent study in rats indicates that the combination of the two is also a potent hypocholesterolemic agent that increases fecal fat excretion. The objective of the present study was to determine the hypocholesterolemic effect of a supplement containing equal amounts of chitosan and glucomannan on blood lipid concentrations and fecal excretion of fat, neutral sterols and bile acids.Methods: Twenty-one overweight normocholesterolemic subjects (I I males and 10 females) were fed 2.4 g/day of a supplement containing equal amounts of chitosan and glucomannan. Prior to taking the supplement (initial period) and after 28 days (final period), blood was drawn for measurement of serum lipids and a three-day fecal sample collected for determination of fat, neutral sterol and bile acid excretion. Subjects maintained their normal dietary and activity patterns during the study.Results: Caloric intake and intake of fat and dietary fiber (excluding the supplement) did not differ between the initial and final periods. Serum total, HDL and LDL cholesterol concentrations were significantly lower (P < 0.05) in the final period compared to the initial period. Serum triacylglycerol concentration did not change between periods. There was a trend towards greater fecal excretion of neutral sterols and bile acids (p = 0.13 and 0.16, respectively) in the final period. However. fecal fat excretion did not differ between periods.Conclusions: Serum cholesterol reduction by a chitosan/glucomannan supplement is likely mediated by increased fecal steroid excretion and is not linked to fat excretion.