4-n-Propylaminopyrimidin | 45815-12-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-n-Propylaminopyrimidin
• 英文别名: propyl-pyrimidin-4-yl-amine；N-propylpyrimidin-4-amine
• CAS: 45815-12-1
• 化学式: C₇H₁₁N₃
• 分子量: 137.184
• InChiKey: VVOIYIAQBRDFQU-UHFFFAOYSA-N

物化性质

• 沸点：
  257.4±13.0 °C(Predicted)
• 密度：
  1.068±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  37.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• FUSED PYRIMIDINES AS ANTAGONISTS OF THE CORTICOTROPIN RELEASING FACTOR (CRF)
  申请人：GLAXO GROUP LIMITED

  公开号：EP1383747A1

  公开（公告）日：2004-01-28
• PYRIMIDINE DERIVATIVES AS 11BETA-HSD1 INHIBITORS
  申请人：F.HOFFMANN-LA ROCHE AG

  公开号：EP1763517A2

  公开（公告）日：2007-03-21
• Biarylurea derivatives
  申请人：Hayama Takashi

  公开号：US20070027147A1

  公开（公告）日：2007-02-01

  The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof: Formula (I) wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R 1 is a hydrogen atom, and so on; R 2 and R 3 are each a hydrogen atom, and so on; R 4 and R 5 are each a hydrogen atom, and so on; and the formula is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.
• ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF
  申请人：AbbVie Inc.

  公开号：US20200291024A1

  公开（公告）日：2020-09-17

  Disclosed herein are methods and compounds of augmenting and enhancing the production of type I IFNs in vivo. In some embodiments, the compounds disclosed herein are ENPP-1 inhibitors, pharmaceutical compositions, and methods for the treatment of cancer or a viral infection.
• US7354946B2
  申请人：——

  公开号：US7354946B2

  公开（公告）日：2008-04-08