2,2-Dimethylbutanoyl bromide | 558432-23-8

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 酰卤
• 英文名称: 2,2-Dimethylbutanoyl bromide
• CAS: 558432-23-8
• 化学式: C₆H₁₁BrO
• 分子量: 179.05
• InChiKey: NFQIMBYJXQGLAG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• ZWITTERIONIC POLYMERS WITH THERAPEUTIC MOIETIES
  申请人：University of Massachusetts

  公开号：US20160346400A1

  公开（公告）日：2016-12-01

  The invention generally relates to zwitterionic polymers (including zwitterionic copolymers), such as polymethacrylic structures, with pendent functional moieties, such as therapeutic or biologic moieties. More particularly, the invention relates to phosphorylcholine-substituted methacrylic polymers prepared by free radical polymerization and click chemistry, for example, and compositions and products comprising same, as well as related methods and uses of the compositions, for example, as biological or therapeutic agents and in drug delivery thereof.

  这项发明通常涉及带有侧链功能基团的带电离子聚合物（包括带电离子共聚物），例如聚甲基丙烯酸结构，其中功能基团为治疗或生物学基团。更具体地，该发明涉及通过自由基聚合和点击化学制备的磷酰胆碱取代的甲基丙烯酸聚合物，以及包括同样的组合物和产品，以及相关方法和使用这些组合物，例如作为生物学或治疗剂以及药物递送的用途。
• [EN] PROCESS FOR THE PREPARATION OF SIMVASTATIN<br/>[FR] PROCEDE DE PREPARATION DE SIMVASTATINE
  申请人：HANMI PHARM IND CO LTD

  公开号：WO2003057684A1

  公开（公告）日：2003-07-17

  Highly pure simvastatin can be prepared economically in a high yield using the method comprising the steps of treating lovastatin with potassium hydroxide dissolved in a mixture of water and methanol to obtain a triol acid; relactonizing the triol acid, and protecting the hydroxy group on the lactone ring; and acylating the resulting compound with 2,2-dimethylbutyryl chloride or 2,2-dimethylbutyryl bromide in the presence of an acylation catalyst in an organic solvent, followed by removing the silyl protecting group on the lactone ring to obtain simvastatin.

  高纯度辛伐他汀可以经济地高产制备，其方法包括以下步骤：将洛伐他汀用在水和甲醇混合物中溶解的氢氧化钾处理，以得到三醇酸；再环化三醇酸，并保护内酯环上的羟基；在有机溶剂中，在酰化催化剂的存在下，用2,2-二甲基丁酰氯或2,2-二甲基丁酰溴酰化所得化合物，然后去除内酯环上的硅保护基，以获得辛伐他汀。
• Process for the preparation of simvastatin
  申请人：Lee Jaeheon

  公开号：US20050080275A1

  公开（公告）日：2005-04-14

  Highly pure simvastatin can be prepared economically in a high yield using the method comprising the steps of treating lovastatin with potassium hydroxide dissolved in a mixture of water and methanol to obtain a triol acid; relactonizing the triol acid, and protecting the hydroxy group on the lactone ring; and acylating the resulting compound with 2,2-dimethylbutyryl chloride or 2,2-dimethylbutyryl bromide in the presence of an acylation catalyst in an organic solvent, followed by removing the silyl protecting group on the lactone ring to obtain simvastatin.

  高纯度辛伐他汀可以经济地高产率制备，其方法包括以下步骤：用溶解在水和甲醇混合物中的氢氧化钾处理洛伐他汀，以获得三醇酸；再环酯化三醇酸，并保护内酯环上的羟基；然后在有机溶剂中，在酰化催化剂的存在下，用2,2-二甲基丁酰氯或2,2-二甲基丁酰溴酰化所得化合物，接着去除内酯环上的硅保护基，以获得辛伐他汀。
• Zwitterionic polymers with therapeutic moieties
  申请人：University of Massachusetts

  公开号：US10632206B2

  公开（公告）日：2020-04-28

  The invention generally relates to zwitterionic polymers (including zwitterionic copolymers), such as polymethacrylic structures, with pendent functional moieties, such as therapeutic or biologic moieties. More particularly, the invention relates to phosphorylcholine-substituted methacrylic polymers prepared by free radical polymerization and click chemistry, for example, and compositions and products comprising same, as well as related methods and uses of the compositions, for example, as biological or therapeutic agents and in drug delivery thereof.

  本发明一般涉及具有下垂功能分子（如治疗或生物分子）的聚甲基丙烯酸酯结构等齐 聚物（包括齐聚物共聚物）。更具体地说，本发明涉及通过自由基聚合和点击化学等方法制备的磷酸胆碱取代的甲基丙烯酸聚合物，以及包含这些聚合物的组合物和产品，以及这些组合物的相关方法和用途，例如用作生物或治疗剂及其药物输送。
• PROCESS FOR THE PREPARATION OF SIMVASTATIN
  申请人：Hanmi Pharm. Co., Ltd.

  公开号：EP1463723A1

  公开（公告）日：2004-10-06