1-cyclopropanecarbonyl-3-(1-naphthyl)thiourea | 66840-23-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-cyclopropanecarbonyl-3-(1-naphthyl)thiourea
• 英文别名: 1-Cyclopropan-carbonyl-3-(α-naphthyl)-thioharnstoff；N-(naphthalen-1-ylcarbamothioyl)cyclopropanecarboxamide
• CAS: 66840-23-1
• 化学式: C₁₅H₁₄N₂OS
• 分子量: 270.355
• InChiKey: JCMPXNKQVJKZKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  73.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-萘胺 、 硫氰酸铵 、 环丙基甲酰氯 以 丙酮 为溶剂， 以75%的产率得到1-cyclopropanecarbonyl-3-(1-naphthyl)thiourea
  参考文献：
  名称：

  One-pot and two-step synthesis of novel carbonylthioureas and dicarbonyldithioureas derivatives

  摘要：

  One-pot, two-step synthesis of several 1-cyclopropanecarbony1-3-(substituted phenyl)-thioureas and 1(phenylene-1,4-dione)-3,3'-(substituted phenyl)-dithioureas have been successfully prepared. The structures of the synthesized compounds were confirmed by elemental analysis, FT-IR spectroscopy and NMR. Also the crystal structure one of these compounds was determined by X-ray crystallography. All synthesized compounds were evaluated for antibacterial activity using Salmonella enterica (SE), Micrococcus luteus (ML), Bacillus subtilis (BS) and Pseudomonas aeruginosa (PS). (C) 2015 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2015.06.074