N-propyloctan-1-amine | 75898-40-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-propyloctan-1-amine
• 英文别名: octyl-propyl-amine；Octyl-propyl-amin；1-Octanamine, N-propyl-
• CAS: 75898-40-7
• 化学式: C₁₁H₂₅N
• mdl: MFCD03551930
• 分子量: 171.326
• InChiKey: BBFLXVFMAOURDU-UHFFFAOYSA-N

物化性质

• 沸点：
  224.4±8.0 °C(Predicted)
• 密度：
  0.782±0.06 g/cm3(Predicted)
• 保留指数：
  1246

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  12
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-propyloctan-1-amine 在 N,N-二异丙基乙胺 、 sodium hydroxide 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 4.0h， 生成 3-(propyl(octyl)amino)-3-oxopropanoic acid
  参考文献：
  名称：

  Immunosuppressive but Non-LasR-Inducing Analogues of the Pseudomonas aeruginosa Quorum-Sensing Molecule N-(3-Oxododecanoyl)-l-homoserine Lactone

  摘要：

  The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-l-homoserine lactone (1) is involved not only in bacterial activation but also in subversion of the host immune system, and this compound might thus be used as a template to design immunosuppressive agents, provided derivatives devoid of quorum-sensing activity could be discovered. By use of a leukocyte proliferation assay and a newly developed bioluminescent P. aeruginosa reporter assay, systematic modification of 1 allowed us to delineate the bacterial LasR-induction and host immunosuppressive activities. The main determinant is replacement of the methylene group proximal to the beta-ketoamide in the acyl chain of 1 with functions containing heteroatoms, especially an NH group. This modification can be combined with replacement of the homoserine lactone system in 1 with stable cyclic groups. For example, we found the simple compound N(1)-(5-chloro-2-hydroxyphenyl)-N(3)-octylmalonamide (25d) to be over twice as potent as 1 as an immune suppressor while displaying LasR-induction antagonist activity.

  DOI：

  10.1021/jm2001019
• 作为产物：
  描述：

  辛胺 、 1-氯丙烷 生成 N-propyloctan-1-amine
  参考文献：
  名称：

  Derivatives of Dimethylaminoethanol and Dimethylaminoethylamine

  摘要：

  DOI：

  10.1021/ja01125a050

文献信息

• Biocatalytic <i>N</i>-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades
  作者：Jeremy I. Ramsden、Rachel S. Heath、Sasha R. Derrington、Sarah L. Montgomery、Juan Mangas-Sanchez、Keith R. Mulholland、Nicholas J. Turner

  DOI：10.1021/jacs.8b11561

  日期：2019.1.23

  The alkylation of amines with either alcohols or carboxylic acids represents a mild and safe alternative to the use of genotoxic alkyl halides and sulfonate esters. Here we report two complementary one-pot systems in which the reductive aminase (RedAm) from Aspergillus oryzae is combined with either (i) a 1° alcohol/alcohol oxidase (AO) or (ii) carboxylic acid/carboxylic acid reductase (CAR) to affect

  胺与醇或羧酸的烷基化代表了使用遗传毒性烷基卤化物和磺酸酯的温和且安全的替代方案。在这里，我们报告了两种互补的一锅系统，其中来自米曲霉的还原胺酶 (RedAm) 与 (i) 1° 酒精/酒精氧化酶 (AO) 或 (ii) 羧酸/羧酸还原酶 (CAR) 结合影响 N-烷基化反应。两种方法的应用都在底物范围和制备规模合成方面得到了举例说明。这些新的生物催化方法解决了替代传统合成方案面临的问题，例如苛​​刻的条件、过度烷基化和复杂的后处理程序。
• [EN] KINASE INHIBITORS<br/>[FR] INHIBITEURS DE KINASE
  申请人：DEVGEN NV

  公开号：WO2005082367A1

  公开（公告）日：2005-09-09

  The invention provides the use of a compound or a composition comprising said compound for inhibiting the activity of at least one kinase, other than ROCK kinase, in vitro or in vivo, pharmaceutical and/or veterinary compositions comprising such compounds, medical and veterinary uses of such compounds and the compounds themselves.

  该发明提供了一种化合物或含有该化合物的组合物用于抑制体外或体内至少一种激酶（除ROCK激酶外）的活性，包括这些化合物的药用和/或兽医学组合物，这些化合物的医药和兽医用途以及化合物本身。
• The selective preparation of n-propylamines by the rhodium catalysed reaction of ethylene and syngas with alkylamines
  作者：M.D. Jones

  DOI：10.1016/0022-328x(89)87190-6

  日期：1989.5

  The aminomethylation of ethylene with a primary amine has been shown to provide a highly selective route to n-propylamines; the rhodium catalysed reaction of n-propylamine with ethylene and syngas (2/1, H2/CO) affords di-n-propylamine with 98% selectivity (with respect to ethylene). The reaction of amines of the type RR1NH with the ethylene/syngas mixture and a rhodium catalyst provides a highly selective

  已显示乙烯与伯胺的氨基甲基化为正丙胺提供了高度选择性的途径。n-丙胺与乙烯和合成气（2 / 1，H 2 / CO）的铑催化反应得到二正丙胺（相对于乙烯）具有98％的选择性。RR 1 NH型胺与乙烯/合成气混合物和铑催化剂的反应为正丙胺RR 1 NPr（R = Pr，R 1 = H; R = t-Bu）提供了高度选择性和通用的途径，R 1 = H； R = n-Bu，R 1 = H； R = C 8 H 17，R 1 = H，R = R 1 = Pr； R = HOCH 2 CH在图2中，R 1＝ H，R ＝ PhCH（OH）CH 2，R 1＝ H）。
• PLATINUM COMPOUND HAVING AMINO OR ALKYLAMINO-CONTAINING SUCCINIC ACID DERIVATIVES AS LEAVING GROUP, PREPARTION METHOD THEREOF, AND USE THEREOF
  申请人：BEIJING FSWELCOME TECHNOLOGY DEVELOPMENT CO., LTD.

  公开号：US20140349985A1

  公开（公告）日：2014-11-27

  Disclosed are a category of platinum compounds having amino- or alkylamino-containing succinato derivatives as leaving group, or pharmaceutically acceptable salts thereof, preparation method thereof, and medicinal compositions containing the compounds. Also disclosed is a use of the compounds in treating cell proliferative diseases, especially cancers. The platinum compounds of the present invention have high water solubility and small toxic side effect.

  本发明揭示了一类铂化合物，其具有氨基或烷基氨基含有琥珀酸酯衍生物作为脱离基团，或其药用可接受的盐，以及其制备方法，以及含有这些化合物的药物组合物。本发明还揭示了这些化合物在治疗细胞增殖性疾病，特别是癌症方面的用途。本发明的铂化合物具有高水溶性和小毒副作用。
• [EN] SURFACE TREATMENTS<br/>[FR] TRAITEMENTS DE SURFACE
  申请人：BOVIN NICOLAI VLADIMIROVICH

  公开号：WO2016185331A1

  公开（公告）日：2016-11-24

  Methods of treating surfaces to provide an antibacterial surface or a surface to which micro-dimensioned particles will adhere are disclosed. Water dispersible selenide-lipid and polycation-lipid constructs for use in the methods are also disclosed.

  公开了用于提供抗菌表面或微维粒子附着表面的处理表面的方法。还公开了用于这些方法的可水分散的硒脂和阳离子脂质构建物。