N,4-Diethylbenzene-1-sulfonamide | 477482-94-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,4-Diethylbenzene-1-sulfonamide
• 英文别名: N,4-diethylbenzenesulfonamide
• CAS: 477482-94-3
• 化学式: C₁₀H₁₅NO₂S
• mdl: MFCD05086827
• 分子量: 213.3
• InChiKey: LTXFHGMNQJDHBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Modulators of ATP-Binding Cassette Transporters
  申请人：Hadida Ruah Sara S.

  公开号：US20120322798A1

  公开（公告）日：2012-12-20

  Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTC”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

  本发明的化合物及其药学上可接受的组成物，可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜传导调节因子（“CFTC”）。本发明还涉及使用本发明的化合物治疗ABC转运蛋白介导的疾病的方法。
• Process for preparation of modified polyethylene terphthalate with improved barrier, mechanical and thermal properties and products thereof
  申请人：ESTER INDUSTRIES LIMITED

  公开号：US10174162B2

  公开（公告）日：2019-01-08

  The present invention relates to a copolyester having intrinsic viscosity greater than 0.50 dL/gm, comprises: terephthalate polyester composition; and a modified transparent polybutylene naphthalate, wherein the modified polybutylene naphthalate comprises naphthalene dicarboxylic acid, 1,4-butane diol, and isophthalic acid or monoethylene glycol or diethylene glycol or cyclohexane dimethanol or polyethylene naphthalate, nucleating agent, and a modified nanoclay.

  本发明涉及一种本征粘度大于 0.50 dL/gm，包括：对苯二甲酸酯聚酯组合物；和改性透明聚萘二甲酸丁二醇酯，其中改性聚萘二甲酸丁二醇酯包括萘二羧酸、1,4-丁二醇和间苯二甲酸或单乙二醇或二甘醇或环己烷二甲醇或聚萘二甲酸乙二醇酯、成核剂和改性纳米粘土。
• Methylsulfonamide derivatives and uses related thereto
  申请人：Emory University

  公开号：US10434195B2

  公开（公告）日：2019-10-08

  This disclosure relates to methylsulfonamide derivatives and uses as imaging agents and other uses related to CXCR4 inhibition. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed herein, derivatives, or pharmaceutically acceptable salts or prodrugs thereof. In certain embodiments, the compositions disclosed herein are used for imaging to study CXCR4 related conditions.

  本公开涉及甲基磺酰胺衍生物和作为成像剂的用途以及与 CXCR4 抑制有关的其他用途。在某些实施方案中，本公开涉及包含本文公开的化合物、衍生物或其药学上可接受的盐或原药的药物组合物。在某些实施方案中，本文公开的组合物用于成像，以研究与 CXCR4 相关的病症。
• HEPATITIS C VIRUS INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP2086963B1

  公开（公告）日：2015-09-16
• SULFONATED CO-POLYESTERS AND METHOD FOR MANUFACTURING
  申请人：Ester Industries Limited

  公开号：EP3107949A1

  公开（公告）日：2016-12-28