5-(氯甲基)-2,3-吡啶二羧酸 | 150022-94-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 5-(氯甲基)-2,3-吡啶二羧酸
• 英文名称: 5-chloromethyl-2,3-pyridinedicarboxylic acid
• 英文别名: 5-(Chloromethyl)pyridine-2,3-dicarboxylic acid
• CAS: 150022-94-9
• 化学式: C₈H₆ClNO₄
• 分子量: 215.593
• InChiKey: JBKRIODDVXLROM-UHFFFAOYSA-N

物化性质

• 沸点：
  478.3±45.0 °C(Predicted)
• 密度：
  1.592±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  87.5
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2933399090

反应信息

• 作为产物：
  描述：

  5-chloromethyl-2,3-pyridinedicarboxylic anhydride 生成 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydride 、 5-(氯甲基)-2,3-吡啶二羧酸
  参考文献：
  名称：

  5 (and/or 6) substituted 2-(2-imidazolin-2-yl)nicotinic acids, esters

  摘要：

  提供了新型的5(和/或6)取代的2-(2-咪唑啉-2-基)和2-(2-咪唑啉基)烟酸、酯和盐，它们可用作除草剂。同时还提供了新型的取代吡咯吡啶乙腈、吡咯吡啶乙酰胺、咪唑吡咯吡啶二酮和氨基甲酰烟酸酯，它们可用作上述除草剂的中间体。

  公开号：

  US05334576A1

文献信息

• Process for the preparation of dialkyl, pyridine-2,3-dicarboxylates and derivatives thereof from dialkyl dichloromaleate
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0461401A1

  公开（公告）日：1991-12-18

  There is provided a process for the preparation of substituted and unsubstituted-2,3-pyridinedicarboxylate compounds by reacting a dialkyl dichloromaleate with a source of ammonia and an appropriately substituted α,β-unsaturated aldehyde or ketone.

  提供了一种制备取代和未取代的2,3-吡啶二羧酸酯化合物的方法，通过将二烷基二氯马来酸酯与氨源和适当取代的α，β-不饱和醛或酮反应。
• Process for the preparation of dialkyl pyridine -2,3-dicarboxylates and derivatives thereof from dialkyl dichloromaleate
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0548559A1

  公开（公告）日：1993-06-30

  There is provided a process for the preparation of substituted and unsubstituted-2,3-pyridinedicarboxylate compounds by reacting a dialkyl dichloromaleate with a dialkylamine to form an enamine intermediate and reacting said intermediate with an appropriately substituted α,β-unsaturated aldehyde or ketone and an ammonia source, as shown in Flow Diagam I:

  提供了一种制备取代和未取代的2,3-吡啶二甲酸酯化合物的方法，通过将二烷基二氯马来酸酯与二烷基胺反应形成恩酰亚胺中间体，并将该中间体与适当取代的α，β-不饱和醛或酮以及氨源反应，如流程图I所示。
• Novel 5(and/or 6)substituted 2-(2-imidazolin-2-yl)nicotinic acids, esters and salts, useful as herbicidal agents and nivel intermediates for the preparation of said nicotinic acids, esters and salts
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0322616A2

  公开（公告）日：1989-07-05

  There are provided novel 5(and/or 6)substituted 2-(2-imidazolin-2-yl) and 2-(2-imidazolidinyl)nicotinic acids, esters and salts, which are useful as herbicidal agents. There are also provided novel substituted pyrrolopyridine acetonitriles, pyrrolopyridine acetamides, imidazopyrrolopyridinediones and carbamoylnicotinic acid esters, that are useful as intermediates for the preparation of the above said herbicidal agents.

  提供了新型 5(和/或 6)取代的 2-(2-咪唑啉-2-基)和 2-(2-咪唑啉基)烟酸、酯和盐，可用作除草剂。此外，还提供了新型取代的吡咯并吡啶乙腈、吡咯并吡啶乙酰胺、咪唑并吡啶二酮和氨基甲酰基烟酸酯，可用作制备上述除草剂的中间体。
• Process for the preparation of pyridine-2,3-dicarboxylic acids
  申请人：CELGENE CORPORATION

  公开号：EP0390102A2

  公开（公告）日：1990-10-03

  Pyridine-2,3-dicarboxylic acids are prepared by the action of 2,3-dihydroxybenzoate-3,4-dioxygenase on 2,3-dihydroxybenzoic acids in a liquid medium which lacks active decarboxylase and which has a pH from 4 to 9, an ionic strength below about 1 molar, and a low concentration of metal cations and complex anions. In close temporal proximity, the 2-hydroxy-3-carboxy­muconic acid semialdehyde which forms is allowed to react with a source of ammonia or a primary amine, avoiding substantial decarboxylation.

  吡啶-2,3-二羧酸是由 2,3-二羟基苯甲酸-3,4-二氧 化酶在缺乏活性脱羧酶的液体介质中作用于 2,3-二羟基苯甲酸制备的，该介质的 pH 值为 4 至 9，离子强度低于约 1 摩尔，金属阳离子和复合阴离子的浓度较低。在时间上接近的情况下，形成的 2-羟基-3-羧基丁二酸半醛可与氨源或伯胺发生反应，从而避免大量脱羧。
• Process for the preparation of dialkyl pyridine-2,3-dicarboxylate and derivatives thereof from dialkyl dichlorosucciante
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0461403A1

  公开（公告）日：1991-12-18

  There is provided a process for the preparation of substituted and unsubstituted-2,3-pyridinedicarboxylate compounds by reacting a dialkyl dichlorosuccinate with a dehydrohalogenating agent, an ammonia source and an appropriately substituted α,β-unsaturated aldehyde or ketone.

  本发明提供了一种通过二烷基二氯琥珀酸酯与脱氢卤化剂、氨源和适当取代的 α、β-不饱和醛或酮反应制备取代和未取代的 2,3-吡啶二甲酸酯化合物的工艺。