triethylammonium benzenethiolate | 37602-52-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯硫酚类
• 英文名称: triethylammonium benzenethiolate
• 英文别名: triethylammonium thiophenolate；Triethylammonium thiophenoxide；benzenethiolate;triethylazanium
• CAS: 37602-52-1
• 化学式: C₆H₅S*C₆H₁₆N
• 分子量: 211.371
• InChiKey: RCLSHBDBAGGVLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.32
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  4.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  triethylammonium benzenethiolate 、 5'-O-(4,4'-Dimethoxytrityl)-4-thiocyanatothymidine 以 二氯甲烷 为溶剂， 生成 5'-O-(4,4'-Dimethoxytrityl)-4-(S-phenyl)-thiothymidine
  参考文献：
  名称：

  5′-O-(4-4′-dimethylthoxytrityl)-4-thiocyanatothymidine A useful intermediate for the preparation of various 4-substituted thymidine analogues

  摘要：

  The thiocyanato group in 5'-O-(4,4'-dimethoxytrityl)-4-thiocyanatothymidine 2 is easily displaced by a variety of O-, N- and S-nucleophiles, making this compound a useful intermediate for the preparation of 4-substituted thymidine analogues.

  DOI：

  10.1016/s0040-4039(00)74367-x

文献信息

• Enantioselective Synthesis of 3‐Heterosubstituted‐2‐amino‐1‐ols by Sequential Metal‐Free Diene Aziridination/Kinetic Resolution
  作者：Irene Giménez‐Nueno、Joan Guasch、Ignacio Funes‐Ardoiz、Feliu Maseras、M. Isabel Matheu、Sergio Castillón、Yolanda Díaz

  DOI：10.1002/chem.201902734

  日期：2019.9.25

  A general protocol for the enantioselective synthesis of 3-heterosubstituted-2-amino-1-ols was developed based on metal- free intramolecular regio- and stereoselective diene aziridination and regioselective opening. Kinetic resolution of the resulting (1'-NR1 R2 and 1'-SR)-4-oxazolidinones was performed using ABCs organocatalysts, expanding the application of this methodology.

  基于无金属的分子内区域和立体选择性二烯叠氮化和区域选择性开放，开发了3-杂取代的2-氨基-1-醇对映选择性合成的通用方案。使用ABCs有机催化剂对所得的（1'-NR1 R2和1'-SR）-4-恶唑烷酮进行动力学拆分，从而扩大了该方法的应用范围。
• Nucleophilic addition to coordinated allyl ligands. Heteroatom nucleophiles with cationic molybdenum complexes
  作者：W.E. Vanarsdale、R.E.K. Winter、J.K. Kochi

  DOI：10.1016/0022-328x(85)80337-5

  日期：1985.11

  sulfide was also converted stereospecifically to a single isomeric sulfoxide with m-chloroperbenzoic acid. Such a chiral oxidation of a sulfide to a sulfoxide is compared with the rather unselective sulfoxidation of the free phenyl 3-cyclooctenyl sulfide by the same reagent. The stereospecificity is analyzed in terms of steric features inherent of allyl sulfides coordinated to an optically active metal center

  在加入异阴离子（甲醇，氢化物，alkylnitronate和硫醇盐）进行一系列的πallylmolybdenum至η相关阳离子的5 -C 5 H ^ 5的Mo（CO）（NO）（η 3 -烯丙基）+了检查。在每种情况下，都分离了在配位烯丙基基团末端的亲核攻击产生的加合物。发现将硫酚盐添加到环辛烯基类似物中，以高产率仅产生一种立体异构体。协调苯基3-环辛烯基硫化物也立体有择转化成具有单一的异构体亚砜米-氯过苯甲酸。将这种硫化物手性氧化为亚砜与通过相同试剂对游离苯基3-环辛烯基硫化物的非选择性硫氧化进行了比较。根据与光学活性金属中心配位的烯丙基硫化物固有的空间特征来分析立体特异性。
• Acetyl substitution of the cyclopentadienyl ligand in molybdenum complexes; nucleophilic additions to coordinated allyl groups
  作者：W.E. Vanarsdale、J.K. Kochi

  DOI：10.1016/0022-328x(86)80524-1

  日期：1986.12

  (η5-AcCp)Mo(CO)2(η3-allyl) (II) reveals a slightly distorted cyclopentadienyl ring and an effective enlargement (i.e., expanded locus) of the ligand as a result of acetyl substitution. The stereoelectronic consequences of the substituted cyclopentadienyl ligand (η5-AcCp) are found in the relative populations of the exo- and endo-conformations of the coordinated allyl ligands in both II as well as in its derived cation

  环戊二烯基的一个不寻常的乙酰基取代的配体的烯丙基的合成过程中，观察到（η 5 -Cp）的Mo（CO）2（I）是对氯（烯丙基）的Mo（CO）的亲核置换2（NCMe）2根据与lithiocyclopentadiene海特。乙酰基的起源是通过氘标记研究确定的，并且在配位乙腈活化为LiCp亲核加成反应方面是合理的。的（η的X射线晶体结构5 -AcCp）的Mo（CO）2（η 3-烯丙基）（II）揭示了一个稍微扭曲的环戊二烯基环和由于乙酰基取代而导致的有效配体扩大（即，扩大的位点）。取代的环戊二烯配位体（η的立体电子后果5 -AcCp）在的相对群的发现外-和内切在两个II协调烯丙基配体的-conformations以及在其衍生的阳离子IV（η 5 -AcCp）沫（CO）（NO）（η 3 -烯丙基）+分别与它们的未取代类似物I和III进行比较。在与氢化物，硫醇根阴离子和碳负离子向阳离子烯丙基配合物IV亲
• Process for producing modified inorganic polymers, their use in producing polynucleotides, and a reagent useful in these processes
  申请人：UNIVERSITY PATENTS, INC.

  公开号：EP0035719A2

  公开（公告）日：1981-09-16

  Modified inorganic polymers represented by the formula wherein Ⓟ is an inorganic polymer linked to the 3' or 5' -0- of the nucleoside through a base hydrolyzable covalent bond; R is H or a blocking group; R is a hydrocarbyl radical containing up to 10 carbons; each B is a nucleoside or deoxynucleoside base; and each A is H or OR. Said inorganic polymers are chemically bound to a nucleoside. The chemical bonding of the nucleoside moiety to the inorganic polymer is by means of reactive groups on the polymer which react with reactive groups of the nucleoside molecule. Such modified inorganic polymer supports are useful in the stepwise addition of nucleosides or oligonucleotides to the original nucleoside moiety of the support by a series of process steps. The starting nucleoside which is blocked in either the 3'- or the 5'-OH and the nucleoside is coupled through the unblocked hydroxy group to the polymer support bythe coupling agent. Furthermore an automated apparatus for producing a modified silica gel which is an example of a modified inorganic polymer is shown.

  由式表示的改性无机聚合物 其中 Ⓟ是通过可水解共价键与核苷的 3'或 5'-0-相连的无机聚合物；R 是 H 或封端基；R 是含有最多 10 个碳原子的烃基；每个 B 是核苷或脱氧核苷碱基；每个 A 是 H 或 OR。所述无机聚合物与核苷进行化学键合。核苷分子与无机聚合物的化学结合是通过聚合物上的反应基团与核苷分子的反应基团进行的。这种改性的无机聚合物载体适用于通过一系列工艺步骤将核苷或寡核苷酸逐步添加到载体的原始核苷分子上。起始核苷的 3'-或 5'-羟基被阻断，核苷通过未被阻断的羟基被偶联剂偶联到聚合物载体上。此外，图中还展示了一种生产改性硅胶的自动化设备，改性硅胶是改性无机聚合物的一个例子。
• Nucleoside phosphite compounds
  申请人：UNIVERSITY PATENTS, INC.

  公开号：EP0097805A2

  公开（公告）日：1984-01-11

  New compounds of the formula wherein B is a nucleoside or deoxynucleoside base; R is H or a blocking group, A is H or OR; R, is a hydrocarbyl radical containing up to 10 carbon atoms and X is a secondary amino group. The new compounds can be chemically bound to an inorganic polymer. The chemical bonding of the nucleoside moiety to the inorganic polymer is by means of reactive groups on the polymer which react with reactive groups of the nucleoside molecule. Such modified inorganic polymer supports are useful in the stepwise addition of nucleosides or oligonucleotides to the original nucleoside moiety of the support by a series of process steps. The starting nucleoside which is blocked in either the 3'- or the 5'-OH and the nucleoside is coupled through the unblocked hydroxy group to the polymer support by the coupling agent. Furthermore an automated apparatus for producing a modified silica gel which is an example of a modified inorganic polymer is shown.

  式中的新化合物 其中 B 是核苷或脱氧核苷碱基；R 是 H 或封端基团，A 是 H 或 OR；R，是含有最多 10 个碳原子的烃基，X 是仲氨基。新化合物可与无机聚合物化学结合。核苷分子与无机聚合物的化学结合是通过聚合物上的反应基团与核苷分子的反应基团进行的。这种改性无机聚合物载体适用于通过一系列工艺步骤将核苷或寡核苷酸逐步添加到载体的原始核苷分子中。起始核苷的 3'-或 5'-羟基被阻断，核苷通过未被阻断的羟基被偶联剂偶联到聚合物载体上。此外，图中还展示了一种生产改性硅胶的自动化设备，改性硅胶是改性无机聚合物的一个例子。