2-methyl-N-(4-methylbenzyl)-4-(3-nitrophenyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide | 1197180-31-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-methyl-N-(4-methylbenzyl)-4-(3-nitrophenyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide
• 英文别名: 2-methyl-N-[(4-methylphenyl)methyl]-4-(3-nitrophenyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide
• CAS: 1197180-31-6
• 化学式: C₂₄H₂₂N₄O₃
• 分子量: 414.464
• InChiKey: WBAYASSWLRBPPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  99.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  双乙烯酮 、 2-氨基吡啶 、 间硝基苯甲醛 、 4-甲基苄胺 在 对甲苯磺酸 作用下， 以 二氯甲烷 为溶剂， 反应 11.0h， 以77%的产率得到2-methyl-N-(4-methylbenzyl)-4-(3-nitrophenyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide
  参考文献：
  名称：

  A four-component, one-pot synthesis of highly substituted 1,4-dihydro-1,8-naphthyridine-3-carboxamides

  摘要：

  A new, one-pot, four-component reaction for the synthesis of a novel class of highly substituted 1,4-dihydro-1,8-naphthyridine-3-carboxamide derivatives starting from readily available inputs including aliphatic or aromatic amines, diketene, aromatic aldehydes, and 2-aminopyridines in the presence of a catalytic amount of p-toluenesulfonic acid under mild reaction conditions and in good yields at ambient temperature is described. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2009.08.104

文献信息

• A four-component, one-pot synthesis of highly substituted 1,4-dihydro-1,8-naphthyridine-3-carboxamides
  作者：Ahmad Shaabani、Mozhdeh Seyyedhamzeh、Ali Maleki、Maryam Behnam

  DOI：10.1016/j.tetlet.2009.08.104

  日期：2009.11

  A new, one-pot, four-component reaction for the synthesis of a novel class of highly substituted 1,4-dihydro-1,8-naphthyridine-3-carboxamide derivatives starting from readily available inputs including aliphatic or aromatic amines, diketene, aromatic aldehydes, and 2-aminopyridines in the presence of a catalytic amount of p-toluenesulfonic acid under mild reaction conditions and in good yields at ambient temperature is described. (C) 2009 Published by Elsevier Ltd.