Methoxyanthranilic acid | 25784-01-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methoxyanthranilic acid
• 英文别名: 2-(methoxyamino)benzoic acid
• CAS: 25784-01-4
• 化学式: C₈H₉NO₃
• 分子量: 167.16
• InChiKey: LDWHCPDWEUIULE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] NEUROLOGICALLY-ACTIVE COMPOUNDS<br/>[FR] COMPOSES NEUROLOGIQUEMENT ACTIFS
  申请人：PRANA BIOTECHNOLOGY LTD

  公开号：WO2005095360A1

  公开（公告）日：2005-10-13

  Neurologically-active heterocyclic compounds comprising two fused 6-membered rings with nitrogen atoms at positions 1 and 3, a carboxy group at position 4,and a hydroxy group at position 8, with one ring being aromatic. Processes for the preparation of these compounds and their use as pharmaceutical or veterinary agents, in particular for the treatment of neurological conditions, and more specifically neurodegenerative conditions such as Alzheimer's disease.

  具有神经活性的杂环化合物，包括两个融合的6元环，氮原子位于位置1和3，羧基位于位置4，羟基位于位置8，其中一个环是芳香环。这些化合物的制备过程及其作为药用或兽药剂的用途，特别是用于治疗神经疾病，更具体地说是像阿尔茨海默病这样的神经退行性疾病。
• Neurologically-Active Compounds
  申请人：Kok Gaik Beng

  公开号：US20080119470A1

  公开（公告）日：2008-05-22

  Neurologically-active heterocyclic compounds comprising two fused 6-membered rings with nitrogen atoms at positions 1 and 3, a carboxy group at position 4, and a hydroxy group at position 8, with one ring being aromatic. Processes for the preparation of these compounds and their use as pharmaceutical or veterinary agents, in particular for the treatment of neurological conditions, and more specifically neurodegenerative conditions such as Alzheimer's disease.

  神经活性杂环化合物包括两个融合的6元环，其中氮原子位于1和3位置，羧基位于4位置，羟基位于8位置，其中一个环是芳香环。本发明还涉及制备这些化合物的方法以及它们作为制药或兽医制剂的用途，特别是用于治疗神经疾病，更具体地说是神经退行性疾病，如阿尔茨海默病。
• Process for the preparation of 2-alkoxy-N-(1-azabicyclo[2.2.2]octan-3-yl) aminobenzamides
  申请人：SYNTHELABO

  公开号：EP0190915A2

  公开（公告）日：1986-08-13

  A process for the preparation of 2-alkoxy- N-(1-azabicyclo[2.2.2]octan-3-yl) aminobenzamides, which are gastric pharmaceuticals in monogastric animals having the formaula: wherein R is hydrogen or loweralkyl, R' is lowealkyl, R2 is hydrogen, halo or loweralkoxy, Am is amino, methlamino or dimethylamino is disclosed wherein in the initial step an appropriate monoprotonated 3-aminoquinuclidine strong acid salt and an appropriate amino benzoic acid all in a 50-90 vol. % pyridine in water solution are reacted in the presence of N,N'-dialkylcarbodiimide. The free base may be obtained by conventional procedures from the mixtures with minimal purification effort.

  一种制备 2-烷氧基-N-(1-氮杂双环[2.2.2]辛烷-3-基)氨基苯甲酰胺的工艺，该工艺可作为单胃动物的胃药，其配方如下： 其中 R 是氢或低级烷基、 R' 是低烷基、 R2 是氢、卤素或低级烷氧基，Am 是氨基、甲氨基或二甲氨基 本发明公开了在初始步骤中，在 N,N'-二烷基碳二亚胺的存在下，适当的单质子化 3-氨基奎宁环强酸盐和适当的氨基苯甲酸在 50-90 体积％的吡啶水溶液中发生反应。游离碱可通过常规方法从混合物中获得，纯化工作量极小。
• Method for producing soluble conductive polymer having acidic groups
  申请人：NITTO CHEMICAL INDUSTRY CO., LTD.

  公开号：EP0834885A2

  公开（公告）日：1998-04-08

  A method for producing a soluble conductive polymer having acidic groups, which comprises subjecting to electrolytic polymerization (a) at least one compound selected from the group consisting of acidic group-substituted anilines, acidic group-substituted pyrroles, acidic group-substituted thiophenes, acidic group-substituted furans, acidic group-substituted selenophenes, acidic group-substituted tellurophenes, acidic group-substituted isothianaphthenes, acidic group-substituted isobenzofurans, acidic group-substituted isoindolines, acidic group-substituted isobenzoselenophenes, acidic group-substituted isobenzotellurophenes, and their metal salts, ammonium salts and substituted ammonium salts in a solution containing (b) a basic compound.

  一种生产具有酸性基团的可溶性导电聚合物的方法，该方法包括将 (a) 至少一种选自由酸性基团取代的苯胺、酸性基团取代的吡咯、酸性基团取代的噻吩、酸性基团取代的呋喃、酸性基团取代的硒吩组成的组中的化合物进行电解聚合； (b) 至少一种选自由酸性基团取代的苯胺、酸性基团取代的吡咯、酸性基团取代的噻吩、酸性基团取代的呋喃、酸性基团取代的硒吩组成的组中的化合物进行电解聚合、酸性基团取代的碲苯酚、酸性基团取代的异噻吩、酸性基团取代的异苯并呋喃、酸性基团取代的异吲哚啉、酸性基团取代的异苯并硒吩、酸性基团取代的异苯并呋喃，以及它们的金属盐、铵盐和取代铵盐，在含有 (b) 碱性化合物的溶液中。
• CONDUCTIVE POLYMER, QUALITY CONTROL METHOD FOR CONDUCTIVE POLYMER AND METHOD FOR PURIFYING CONDUCTIVE POLYMER
  申请人：Mitsubishi Rayon Co., Ltd.

  公开号：EP2551290A1

  公开（公告）日：2013-01-30

  The present invention provides a conductive polymer in which, when being formed into a coating film, foreign materials are difficult to be generated even the passage of time and a quality control method for a conductive polymer and has a repeating unit which is represented by the following general formula (1). The present invention also provides a quality control method for conductive polymers wherein conductive polymers with an area ratio (Y/X) of 0.60 or less are selected. In the formula R1 to R4 are each independently -H, a linear or branched alkyl group having 1 to 24 carbon atoms, a linear or branched alkoxy group having 1 to 24 carbon atoms, an acidic group, a hydroxyl group, a nitro group, -F, -Cl, -Br or -I; and at least one of R1 to R4 is an acidic group or a salt thereof.

  本发明提供了一种导电聚合物，其在形成涂膜时，即使经过一段时间也很难产生异物，本发明还提供了一种导电聚合物的质量控制方法，该导电聚合物具有由以下通式（1）表示的重复单元。本发明还提供了一种导电聚合物的质量控制方法，其中选择面积比（Y/X）为 0.60 或以下的导电聚合物。式中 R1 至 R4 各自独立地为-H、具有 1 至 24 个碳原子的直链或支链烷基、具有 1 至 24 个碳原子的直链或支链烷氧基、酸性基团、羟基、硝基、-F、-Cl、-Br 或-I；且 R1 至 R4 中至少有一个为酸性基团或其盐。