isopropyl-methylphosphonic acid | 4721-34-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: isopropyl-methylphosphonic acid
• 英文别名: isobutylphosphonic acid；GB acid；isobutyl-phosphonic acid；Isobutyl-phosphonsaeure；2-Methyl-propan-phosphinsaeure-(1)；Isobutylphosphinsaeure；(2-Methylpropyl)phosphonic acid；2-methylpropylphosphonic acid
• CAS: 4721-34-0
• 化学式: C₄H₁₁O₃P
• mdl: MFCD00985298
• 分子量: 138.103
• InChiKey: HAEFDDOAYBQRGK-UHFFFAOYSA-N

物化性质

• 熔点：
  119°C
• 密度：
  1.083 (estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  isopropyl-methylphosphonic acid 在 尿素 作用下， 以90%的产率得到diisobutyldiphosphonic acid, ammonia salt
  参考文献：
  名称：

  Ohms, G.; Grossmann, G.; Schwab, B., Phosphorus, Sulfur and Silicon and the Related Elements, 1992, vol. 68, # 1-4, p. 77 - 90

  摘要：

  DOI：
• 作为产物：
  描述：

  异丁基膦 在 硝酸 作用下， 生成 isopropyl-methylphosphonic acid
  参考文献：
  名称：

  Hofmann,A.W., Chemische Berichte, 1873, vol. 6, p. 306

  摘要：

  DOI：

文献信息

• Radical-based dephosphorylation and organophosphonate biodegradation
  作者：J. W. Frost、S. Loo、M. L. Cordeiro、D. Li

  DOI：10.1021/ja00241a039

  日期：1987.4

  Products resulting from the degradation of organophosphonates by Escherichia coli are identified and used as a basis for evaluating mechanisms which may be the chemical basis of the biodegradation. One mechanistic hypothesis which is consistent with the biodegradation products involves radical-based dephosphorylation. Chemical modeling of this process is achieved by the reaction of alkylphosphonic

  大肠杆菌降解有机膦酸盐的产物被鉴定并用作评估机制的基础，这些机制可能是生物降解的化学基础。与生物降解产物一致的一种机制假设涉及基于自由基的去磷酸化。该过程的化学建模是通过烷基膦酸与四乙酸铅 (IV) 的反应和铂阳极上的电化学氧化来实现的。
• Method for the production of alkylphosphonic acids, esters, and salts by oxidizing alkylphosphonous acids, and use thereof
  申请人：Hill Michael

  公开号：US09018413B2

  公开（公告）日：2015-04-28

  The invention relates to a method for producing monocarboxy-functionalized dialkylphosphinic acids, esters, and salts, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) in the presence of a catalyst A to obtain an alkylphosphonous acid, the salt or ester (II) thereof, and b) the obtained alkylphosphonous acid, the salt or ester (II) thereof is reacted with an oxidizing agent or with an oxidizing agent and water or with oxygen and water in the presence of a catalyst B to obtain the alkylphosphonic acid derivative (III), wherein R1, R2, R3, R4 are identical or different from each other and independently represent, inter alia, H, C1-C18-alkyl, C6-C18-aryl, C6-C18-aralkyl, C6-C18-alkylaryl, X and Y are identical or different from each other and independently represent H, C1-C18-alkyl, C6-C18-aryl, C6-C18-aralkyl, C6-C18-alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonated nitrogenous base, and catalysts A and B are transition metals and/or transition metal compounds and/or catalyst systems composed of a transition metal and/or a transition metal compound and at least one ligand.

  该发明涉及一种生产单羧基功能化二烷基膦酸、酯和盐的方法，其特征在于a)在催化剂A的存在下，将膦酸源(I)与烯烃(IV)反应，得到一种烷基膦酸、其盐或酯(II)，b)将所得的烷基膦酸、其盐或酯(II)与氧化剂或与氧化剂和水或与氧气和水在催化剂B的存在下反应，得到烷基膦酸衍生物(III)，其中R1、R2、R3、R4相同或不同，独立表示H、C1-C18-烷基、C6-C18-芳基、C6-C18-芳基烷基、C6-C18-烷基芳基，X和Y相同或不同，独立表示H、C1-C18-烷基、C6-C18-芳基、C6-C18-芳基烷基、C6-C18-烷基芳基、Mg、Ca、Al、Sb、Sn、Ge、Ti、Fe、Zr、Zn、Ce、Bi、Sr、Mn、Cu、Ni、Li、Na、K和/或质子化的氮碱基，催化剂A和B是过渡金属和/或过渡金属化合物和/或由过渡金属和/或过渡金属化合物与至少一种配体组成的催化体系。
• The preparation and reactions of primary phosphine oxides
  作者：S.A. Buckler、M. Epstein

  DOI：10.1016/0040-4020(62)80003-9

  日期：1962.1

  The preparation of primary phosphine oxides, RP(O)H2, by the controlled oxidation of primary phosphines is described. Some of the properties of these novel oxides are discussed and their reactions with olefins, carbonyl compounds and isocyanates are reported. These reactions lead to various types of symmetrical and unsymmetrical secondary and tertiary phosphine oxides. Polymers are obtained from reactions

  描述了通过伯膦的受控氧化制备伯膦氧化物RP（O）H 2的方法。讨论了这些新型氧化物的一些性质，并报道了它们与烯烃，羰基化合物和异氰酸酯的反应。这些反应导致各种类型的对称和不对称的仲和叔氧化膦。聚合物是从与二异氰酸酯的反应中获得的。
• [EN] PROCESS FOR THE ALKYLATION OF PHOSPHORUS-CONTAINING COMPOUNDS<br/>[FR] PROCEDE D'ALKYLATION DE COMPOSES CONTENANT DU PHOSPHORE
  申请人：SUPRESTA LLC

  公开号：WO2005105818A1

  公开（公告）日：2005-11-10

  A process for alkylating a phosphorus-containing compound to provide an alkylated phosphorus-containing compound is provided which comprises alkylating 5 phosphorus-containing compound possessing at least one phosphorus-hydrogen alkylatable site with reactant which generates alkene and/or cycloalkene alkylating agent in situ in the presence of initiator, the alkylene and/or cycloalkylene alkylating agent alkylating the phosphorus-containing component to provide alkylated phosphorus-containing product.

  提供一种烷基化含磷化合物的方法，其中包括将至少具有一个磷-氢可烷基化位点的5个磷含量化合物与在引发剂存在下生成烯烃和/或环烷烃烷基化试剂的反应物进行烷基化，所述烯烃和/或环烷烃烷基化试剂烷基化磷含量成分以提供烷基化磷含量产物。
• Process for the preparation of benzothiazepines by cyclization with
  申请人：Zambon Group S.p.A.

  公开号：US05223612A1

  公开（公告）日：1993-06-29

  Process for the preparation of (2S,3S)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H) -one of formula ##STR1## by direct cyclization of the compound of the formula ##STR2## with a catalytic amount of phosphonic acid.

  使用磷酸催化剂，通过化合物##STR2##的直接环化反应，制备公式为##STR1##的(2S,3S)-2,3-二氢-3-羟基-2-(4-甲氧基苯基)-1,5-苯并噻吩-4(5H)-酮。