1-fluoro-5,6-dihydroxynaphthalene | 741693-92-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-fluoro-5,6-dihydroxynaphthalene
• 英文别名: 5-Fluoronaphthalene-1,2-diol
• CAS: 741693-92-5
• 化学式: C₁₀H₇FO₂
• 分子量: 178.163
• InChiKey: RMTQWEPAPMNFSA-UHFFFAOYSA-N

物化性质

• 沸点：
  357.2±22.0 °C(Predicted)
• 密度：
  1.429±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-fluoro-5,6-dihydroxynaphthalene 在 4-甲基苯磺酸吡啶 、 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and biological activity of some known and putative duloxetine metabolites

  摘要：

  Several putative phase I duloxetine metabolites, 4-hydroxy-, 5-hydroxy-, 6-hydroxy-, 5-hydroxy-6-methoxy-, 6-hydroxy5-methoxy-, 5,6-dihydroxy-, and 4,6-dihydroxyduloxetine were synthesized, and their phase II metabolite as glucuronide or sulfate conjugates were also synthesized. Their in vitro binding activities were compared to that of parent compound duloxetine. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.04.066
• 作为产物：
  描述：

  5-氨基-2-萘酚 在 sodium hydroxide 、 tetrafluoroboric acid 、 三氯化硼 、 四氯化锡 、 间氯过氧苯甲酸 、 sodium nitrite 作用下， 以 二氯甲烷 为溶剂， 生成 1-fluoro-5,6-dihydroxynaphthalene
  参考文献：
  名称：

  Synthesis and biological activity of some known and putative duloxetine metabolites

  摘要：

  Several putative phase I duloxetine metabolites, 4-hydroxy-, 5-hydroxy-, 6-hydroxy-, 5-hydroxy-6-methoxy-, 6-hydroxy5-methoxy-, 5,6-dihydroxy-, and 4,6-dihydroxyduloxetine were synthesized, and their phase II metabolite as glucuronide or sulfate conjugates were also synthesized. Their in vitro binding activities were compared to that of parent compound duloxetine. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.04.066

文献信息

• SOLID CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST
  申请人：Toho Titanium Co., Ltd.

  公开号：EP1260524A1

  公开（公告）日：2002-11-27

  The solid catalyst component for polymerization of olefins comprising (a) a magnesium compound, (b) titanium tetrachloride, (c) a phthalic acid diester or a derivative thereof, and (d1) a hydroxy group-containing hydrocarbon compound having a specific structure or (d2) a mercapto group-containing hydrocarbon compound having a specific structure and the olefin polymerization catalyst can produce olefin polymers in a very high yield, particularly can produce propylene polymers in a very high yield, while retaining high stereoregularity.

  用于烯烃聚合的固体催化剂组分包括：(a) 镁化合物；(b) 四氯化钛；(c) 邻苯二甲酸二酯或其衍生物；(d1) 具有特定结构的含羟基烃化合物或 (d2) 具有特定结构的含巯基烃化合物，该烯烃聚合催化剂能以极高的产率生产烯烃聚合物，特别是能以极高的产率生产丙烯聚合物，同时保持较高的立体规整性。
• Solid catalyst component for olefin polymerization and catalyst
  申请人：——

  公开号：US20040072681A1

  公开（公告）日：2004-04-15

  A solid catalyst component for olefin polymerization characterized by being formed from (a) a magnesium compound, (b) titanium tetrachloride, (c) a phthalic diester and a derivative thereof, and either (d 1 ) a hydroxylated hydrocarbon compound (phenol, etc.) represented by a specific formula or (d 2 ) a mercapto-containing hydrocarbon compound (thiophenol, etc.) represented by a specific formula. With a catalyst obtained from this solid catalyst component, an olefin polymer can be obtained in extremely high yield. In particular, a propylene polymer which retains high stereoregularity can be obtained in extremely high yield

  一种用于烯烃聚合的固体催化剂组分，其特征在于它是由(a)镁化合物，(b)四氯化钛，(c)邻苯二甲酸二酯及其衍生物，以及(d) 1 以特定公式表示的羟基烃化合物（苯酚等），或 (d 1) 2 ) 一种由特定公式表示的含巯基的烃化合物（噻吩酚等）。使用由这种固体催化剂组分制成的催化剂，可以获得产量极高的烯烃聚合物。特别是可以获得一种立体规整度很高的丙烯聚合物，产量极高
• US6878659B2
  申请人：——

  公开号：US6878659B2

  公开（公告）日：2005-04-12