N-(2-acetyl-4-bromophenyl)-4-[(4-chlorophenyl)-methylsulfamoyl]benzamide | 946160-84-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-acetyl-4-bromophenyl)-4-[(4-chlorophenyl)-methylsulfamoyl]benzamide
• CAS: 946160-84-5
• 化学式: C₂₂H₁₈BrClN₂O₄S
• 分子量: 521.819
• InChiKey: UOSVHMVVEIFJBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  91.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(2-acetyl-4-bromophenyl)-4-[(4-chlorophenyl)-methylsulfamoyl]benzamide 在 sodium tetrahydroborate 作用下， 生成 N-[4-bromo-2-(1-hydroxyethyl)phenyl]-4-[(4-chlorophenyl)-methylsulfamoyl]benzamide
  参考文献：
  名称：

  Structure–activity relationships of bioisosteres of a carboxylic acid in a novel class of bacterial translation inhibitors

  摘要：

  The discovery and initial optimization of a novel anthranilic acid derived class of antibacterial agents which suffered from extensive protein binding has been previously reported. The structure-activity relationships around the carboxylic acid substituent are described herein. This acid was replaced by several alternative functional groups in attempts to retain bioactivity while reducing protein binding. Only groups with an acidic proton retained activity, and analogs containing those groups maintained the protein binding inherent to this class of antibacterial agents. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.04.074
• 作为产物：
  描述：

  4-氯-N-甲基苯胺 在 吡啶 、 草酰氯 、 三乙胺 、 N,N-二甲基甲酰胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 N-(2-acetyl-4-bromophenyl)-4-[(4-chlorophenyl)-methylsulfamoyl]benzamide
  参考文献：
  名称：

  Structure–activity relationships of bioisosteres of a carboxylic acid in a novel class of bacterial translation inhibitors

  摘要：

  The discovery and initial optimization of a novel anthranilic acid derived class of antibacterial agents which suffered from extensive protein binding has been previously reported. The structure-activity relationships around the carboxylic acid substituent are described herein. This acid was replaced by several alternative functional groups in attempts to retain bioactivity while reducing protein binding. Only groups with an acidic proton retained activity, and analogs containing those groups maintained the protein binding inherent to this class of antibacterial agents. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.04.074

文献信息

• Structure–activity relationships of bioisosteres of a carboxylic acid in a novel class of bacterial translation inhibitors
  作者：J. Craig Ruble、Brian D. Wakefield、Gregg M. Kamilar、Keith R. Marotti、Earline Melchior、Michael T. Sweeney、Gary E. Zurenko、Donna L. Romero

  DOI：10.1016/j.bmcl.2007.04.074

  日期：2007.7

  The discovery and initial optimization of a novel anthranilic acid derived class of antibacterial agents which suffered from extensive protein binding has been previously reported. The structure-activity relationships around the carboxylic acid substituent are described herein. This acid was replaced by several alternative functional groups in attempts to retain bioactivity while reducing protein binding. Only groups with an acidic proton retained activity, and analogs containing those groups maintained the protein binding inherent to this class of antibacterial agents. (C) 2007 Elsevier Ltd. All rights reserved.