diethyl (4-benzoylbenzyl) phosphonate | 118466-21-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diethyl (4-benzoylbenzyl) phosphonate
• 英文别名: Diethyl [(4-benzoylphenyl)methyl]phosphonate；[4-(diethoxyphosphorylmethyl)phenyl]-phenylmethanone
• CAS: 118466-21-0
• 化学式: C₁₈H₂₁O₄P
• 分子量: 332.336
• InChiKey: KTDNUVISWQZPQW-UHFFFAOYSA-N

物化性质

• 沸点：
  474.0±38.0 °C(Predicted)
• 密度：
  1.158±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  diethyl (4-benzoylbenzyl) phosphonate 在 水 、 乙酸乙酯 、 Sodium sulfate-III 作用下， 以 盐酸 为溶剂， 反应 7.0h， 以to give 0.7 g of product的产率得到(4-苯甲酰基苯基)甲基膦酸
  参考文献：
  名称：

  Benzylphosphonic acid tyrosine kinase inhibitors

  摘要：

  某些苯甲基膦酸化合物及其药学上可接受的盐是酪氨酸激酶酶的抑制剂，因此对于控制酪氨酸激酶依赖性疾病（例如癌症、动脉硬化）非常有用。

  公开号：

  US05326905A1
• 作为产物：
  描述：

  4-甲基二苯甲酮 在 N-溴代丁二酰亚胺(NBS) 、 过氧化氢苯甲酰 作用下， 以 四氯化碳 为溶剂， 生成 diethyl (4-benzoylbenzyl) phosphonate
  参考文献：
  名称：

  用N-氟苯磺酰亚胺通过苄基膦酸酯的α-碳负离子的亲电氟化反应合成芳基（二氟亚甲基膦酸酯）

  摘要：

  已经研究了多种苄基膦酸酯与N-氟苯磺酰亚胺的亲电子氟化。在一系列官能团如硝基，溴，酮，酯，苯基和醚基的存在下，氟化反应进行得很好。也可以制备含有两个α，α-二氟亚甲基膦酸酯基的苯基和联苯衍生物。该方法与甲基或乙基膦酸酯相容，但是与叔丁基酯或在对位处含有另外的苄基部分的苄基膦酸酯不相容。

  DOI：

  10.1016/s0040-4020(97)10395-7

文献信息

• Conjugated dyes carrying N, N-dialkylamino and ketone groups: One-component visible light Norrish type II photoinitiators
  作者：Ge Ding、Chuan Jing、Xiaozhuan Qin、Yulong Gong、Xueping Zhang、Shengtao Zhang、Ziping Luo、Hongru Li、Fang Gao

  DOI：10.1016/j.dyepig.2016.10.034

  日期：2017.2

  This work presents new conjugated dyes carrying N, N-dialkylamino and ketone groups for using as one-component Norrish type II visible light photoinitiators. The novel dyes without ketone group were also synthesized to compose two-component visible light photoinitiators for comparisons. The target dyes show the remarkable absorption in visible light region. Photo-differential scanning calorimetry was

  这项工作提出了带有N，N的新型共轭染料-二烷基氨基和酮基用作一组分Norrish II型可见光光引发剂。还合成了没有酮基的新型染料，以组成两组分可见光光引发剂进行比较。目标染料在可见光区域显示出显着的吸收。采用光差扫描量热法分别研究了新型的单组分光引发剂和二组分光引发剂对甲基丙烯酸甲酯的可见光光引发聚合动力学。结果表明，在可见光照射下，一组分光引发剂显示出比二组分光引发体系更有效的甲基丙烯酸甲酯光引发聚合。测定了由新的光引发剂产生的可见光光聚合物的分子量。
• Two-photon Absorption Properties of Novel Conjugated Dyes Containing a Benzophenone Unit
  作者：Jian Liu、Fang Gao、Long Yang、Chunfeng Wang、Hongru Li、Shengtao Zhang

  DOI：10.1246/cl.2010.324

  日期：2010.4.5

  A variety of new conjugated dyes bearing a benzophenone unit were synthesized, and the linear absorption and emission were determined. Two-photon absorption properties of the derivatives have been measured by a Ti:sapphire femtosecond laser tuning from 720 to 880 nm at intervals of 20 nm. One- and two-photon optical properties of the derivatives were found to be significantly dependent on their chemical structures.

  合成了一系列具有苯基酮单元的新型共轭染料，并测定了它们的线性吸收和发射。通过一台从720 nm到880 nm以20 nm为间隔调谐的钛：蓝宝石飞秒激光器，测量了这些衍生物的双光子吸收特性。发现这些衍生物的一光子和双光子光学特性显著依赖于它们的化学结构。
• STILBENE-BASED REACTIVE COMPOUNDS, POLYMERIC MATRICES FORMED THEREFROM, AND ARTICLES VISUALIZABLE BY FLUORESCENCE
  申请人：SurModics, Inc.

  公开号：US20140162083A1

  公开（公告）日：2014-06-12

  The invention is directed to latent reactive and polymerizable derivatives of fluorescent stilbene-based compounds. The compounds can be used to provide articles with a fluorescence property, such as medical devices (e.g., catheters). The fluorescent compounds can be used in association with polymers, or can be incorporated into polymers, and the polymers used in a coating composition on the article surface. The compounds allow for visual or machine inspection of coating properties such as uniformity of coverage.

  这项发明涉及荧光基苯乙烯化合物的潜在反应性和聚合物化衍生物。这些化合物可用于赋予物品荧光特性，例如医疗器械（如导管）。荧光化合物可与聚合物结合使用，或者可以被纳入聚合物中，并且聚合物可用作涂层组合物涂覆在物品表面。这些化合物允许对涂层性能进行目视或机器检查，比如涂层覆盖的均匀性。
• TAILORED CONTROL OF SURFACE PROPERTIES BY CHEMICAL MODIFICATION
  申请人：Moloney Mark

  公开号：US20100068783A1

  公开（公告）日：2010-03-18

  A process for producing a substrate having an adhesive surface, which process comprises: (a) contacting the substrate with a carbene precursor, which carbene precursor is a compound of the following formula (1): whose substituent groups are SP defined herein, provided that when R is aryl or heteroaryl, said aryl or heteroaryl may be substituted by one, two, three, four or five groups, which groups are independently selected from various groups including -L B -W B ; and (b) either: (i) when W A or W B comprises an adhesive functional group, generating a carbene reactive intermediate from the carbene precursor so that it reacts with the substrate to functionalise the surface, thereby yielding said substrate having an adhesive surface; or (ii) when W A or W B comprises a group which is a precursor of an adhesive functional group, generating a carbene reactive intermediate from the carbene precursor so that it reacts with the substrate to functionalise the surface, and (c) converting said group which is a precursor into an adhesive functional group thereby yielding said substrate having an adhesive surface. The invention further relates to carbene precursor compounds for use in the process, substrates produced by the process and to processes for preparing certain precursor compounds.

  一种生产具有粘附表面的基板的方法，该方法包括：(a)将基板与卡宾前体接触，所述卡宾前体是以下式（1）的化合物：其取代基团为本文所定义的SP，但当R为芳基或杂环芳基时，所述芳基或杂环芳基可以被一个、两个、三个、四个或五个独立选择的各种取代基团之一取代，这些取代基团包括-LB-WB；和(b)：要么：(i)当WA或WB包含粘附功能基团时，从卡宾前体生成卡宾活性中间体，使其与基板反应以功能化表面，从而产生具有粘附表面的基板；或(ii)当WA或WB包含是粘附功能基团的前体时，从卡宾前体生成卡宾活性中间体，使其与基板反应以功能化表面，并且(c)将所述作为前体的基团转化为粘附功能基团，从而产生具有粘附表面的基板。该发明还涉及用于该方法的卡宾前体化合物，以及通过该方法生产的基板和用于制备某些前体化合物的方法。
• Synthesis and Spectroscopy of Novel Branched Fluorescent Dyes Containing Benzophenone Parts and the Possibility as Fluorescence Probes
  作者：Fang Gao、Lanying Niu、Nvdan Hu、Jianchao Wang、Hongru Li、Shengtao Zhang

  DOI：10.1007/s10895-010-0699-9

  日期：2011.1

  The optical density of C1, C2 and C3 are shown to be related to the number of branches. The changes of dipole moments between the excited and ground states for C1, C2 and C3 were estimated to be 4.356, 8.091 and 8.479 Derby, respectively by Lippert equation, confirming that the internal charge transfer (ICT) dominates the process of excited singlet state. The possibility as fluorescence probes of the

  本文描述了含有二苯甲酮单元，其包括支化的染料的新型荧光家族4 -N，N-二diphenylamino- 4 '-phenacyl -二苯乙烯（C1），4,4 ' -二（4- benzoylphenylethylene）基-三苯基胺（C2）和4,4',4" -三(4-苯甲酰基苯基亚乙基)基-三苯基胺( C3 )。二苯甲酮部分通过C-C双键与核偶联。衍生物的化学结构用1 H 和13 C 核磁共振和元素分析表征。通过对C1的 X 射线晶体学数据的分析发现了强 π-π 堆积相互作用. 衍生物的吸收最大值和发射最大值表现出从C1到C3 的逐渐红移。C1、C2和C3的光密度显示与分支的数量有关。C1、C2和C3激发态和基态间偶极矩的变化通过Lippert方程估计分别为4.356、8.091和8.479德比，证实内部电荷转移（ICT）主导激发单线态过程。评估了作为衍生物的荧光探针估计胶束与样品相互作用的区域的可能性。