benzaldehyde 4-p-tolyl-thiosemicarbazone | 89713-29-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzaldehyde 4-p-tolyl-thiosemicarbazone
• 英文别名: Benzaldehyd-(4-p-tolyl-thiosemicarbazon)；1-(Benzylideneamino)-3-(4-methylphenyl)thiourea
• CAS: 89713-29-1
• 化学式: C₁₅H₁₅N₃S
• 分子量: 269.37
• InChiKey: UGEVMHUMNGFAAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  68.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  benzaldehyde 4-p-tolyl-thiosemicarbazone 在 溴 作用下， 以 氯仿 为溶剂， 生成 benzaldehyde (6-methyl-benzothiazol-2-yl)-hydrazone
  参考文献：
  名称：

  Oxidative cyclization of 4-arylthio-semicarbazones

  摘要：

  DOI：

  10.1007/bf00755065
• 作为产物：
  描述：

  对甲苯异硫氰酸酯 以 甲醇 、 乙醇 、 水 为溶剂， 反应 6.0h， 生成 benzaldehyde 4-p-tolyl-thiosemicarbazone
  参考文献：
  名称：

  NMR Studies of Saccharide Hydrazones, Thiosemicarbazones and Azines: Model Compounds for Immobilisation Studies

  摘要：

  To evaluate possible chemical strategies for the solid-phase immobilization of sugars, studies on the formation and stability of hydrazones, thiosemicarbazones and azines of D-glucose and 2-acetamido-2-deoxy-D-glucose, and the subsequent release of sugars, were carried out. Hydrazone formation was observed to occur under milder conditions than previously reported, thereby minimising the accompanying N-deacetylation which occurs with N-acetamido sugars. The cyclic beta-pyranosyl structures of the saccharide hydrazones, thiosemicarbazones and azines were the preferred isomers in aqueous solution.

  DOI：

  10.1080/07328309808005766

文献信息

• Diacetoxyiodobenzene mediated oxidative transformation of thione to disulfides
  作者：Sarangthem Joychandra Singh、Nepram Sushuma Devi

  DOI：10.1016/j.tetlet.2016.11.091

  日期：2016.12

  We have developed an efficient oxidative transformation of thione to disulfides using diacetoxyiodobenzene (DIB) in acetonitrile at room temperature. This strategy is suited for oxidation of thiols to disulfide also. The present oxidation protocol is mild reaction condition, column free, and a new route for disulfide formation.

  我们已开发出在室温下使用乙腈中的二乙酰氧基碘苯（DIB）将硫酮有效氧化为二硫化物的方法。该策略也适用于将硫醇氧化为二硫化物。目前的氧化方案是温和的反应条件，无柱，是形成二硫键的新途径。
• Synthesis of 2-amino-substituted-1,3,4-thiadiazoles via 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) mediated intramolecular C–S bond formation in thiosemicarbazones
  作者：Sarangthem Joychandra Singh、Suresh Rajamanickam、Anupal Gogoi、Bhisma K. Patel

  DOI：10.1016/j.tetlet.2016.01.083

  日期：2016.3

  An effective oxidative intramolecular cyclization (C–S bond formation) of thiosemicarbazones using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) has been developed to afford a diverse array of 2-amino-substituted-1,3,4-thiadiazoles. The attractive features of this protocol are operational simplicity, obviates the need of expensive transition-metal catalysts and broad substrate scope.

  已开发出使用2,3-二氯-5,6-二氰基-1,4-苯醌（DDQ）的硫半脲的有效氧化分子内环化（CS键形成），以提供各种2-氨基取代的- 1,3,4-噻二唑。该协议的吸引人的特点是操作简单，无需昂贵的过渡金属催化剂和广泛的底物范围。
• Reactions of N-(1-chloro-2-oxo-2-phenylethyl) carboxamides with thiosemicarbazide and its derivatives
  作者：A. G. Balya、A. N. Vasilenko、V. S. Brovarets、B. S. Drach

  DOI：10.1134/s1070363208110236

  日期：2008.11

  N-(1-Chloro-2-oxo-2-phenylethyl)acet-, -benz-, and -4-methylbenzamides reacted with thiosemicarbazides and aromatic aldehyde thiosemicarbazones to give derivatives of 5-amino-2-hydrazino-1,3-thiazole. The latter underwent recyclization and acid hydrolysis on heating with hydrochloric acid to produce substituted 3-amino-2-thiohydantoins.
• Chande; Joshi, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1997, vol. 36, # 5, p. 403 - 409
  作者：Chande、Joshi

  DOI：——

  日期：——
• De; Roy-Choudhury, Journal of the Indian Chemical Society, 1928, vol. 5, p. 272
  作者：De、Roy-Choudhury

  DOI：——

  日期：——