N-(2-methylallyl)-N-propylhydroxylamine | 1108620-73-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(2-methylallyl)-N-propylhydroxylamine
• 英文别名: N-(2-methylprop-2-enyl)-N-propylhydroxylamine
• CAS: 1108620-73-0
• 化学式: C₇H₁₅NO
• 分子量: 129.202
• InChiKey: VGGANCKLHZRZRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  降冰片烯 、 N-(2-methylallyl)-N-propylhydroxylamine 以 苯 为溶剂， 反应 45.0h， 以48%的产率得到N-(2-methylallyloxy)-N-propylbicyclo[2.2.1]heptan-2-amine
  参考文献：
  名称：

  Bourgeois, Joffre; Dion, Isabelle; Cebrowski, Pamela H., Journal of the American Chemical Society, 2009, vol. 131, p. 874 - 875

  摘要：

  DOI：
• 作为产物：
  描述：

  丙胲 、 3-氯-2-甲基丙烯 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以42%的产率得到N-(2-methylallyl)-N-propylhydroxylamine
  参考文献：
  名称：

  Bourgeois, Joffre; Dion, Isabelle; Cebrowski, Pamela H., Journal of the American Chemical Society, 2009, vol. 131, p. 874 - 875

  摘要：

  DOI：

文献信息

• Binding molecules for treatment and detection of cancer
  申请人：Crucell Holland B.V.

  公开号：EP2279749A1

  公开（公告）日：2011-02-02

  The present invention provides new tumor-associated antigens, binding molecules that specifically bind to the antigens, nucleic acid molecules encoding the binding molecules, compositions comprising the binding molecules and methods of identifying or producing the binding molecules. The new tumor-associated antigen are expressed on cancer cells and binding molecules capable of specifically binding to the antigens can be used in the diagnosis, prevention and/or treatment of cancer.

  本发明提供了新的肿瘤相关抗原、与抗原特异性结合的结合分子、编码结合分子的核酸分子、包含结合分子的组合物以及鉴定或生产结合分子的方法。新的肿瘤相关抗原在癌细胞上表达，能与抗原特异性结合的结合分子可用于癌症的诊断、预防和/或治疗。
• Myeloid cell-specific lectin
  申请人：Crucell Holland B.V.

  公开号：EP2322547A1

  公开（公告）日：2011-05-18

  The present invention provides a human C-type lectin, binding molecules that specifically bind to the human C-type lectin, nucleic acid molecules encoding the binding molecules or the human C-type lectin, compositions comprising the binding molecules or the human C-type lectin and methods of identifying or producing the binding molecules. The human C-type lectin is specifically expressed on myeloid cells and binding molecules capable of specifically binding to the human C-type lectin can be used in the diagnosis, prevention and/or treatment of neoplastic disorders and diseases.

  本发明提供了一种人C型凝集素、与人C型凝集素特异性结合的结合分子、编码结合分子或人C型凝集素的核酸分子、包含结合分子或人C型凝集素的组合物以及鉴定或生产结合分子的方法。人 C 型凝集素特异性地表达在髓细胞上，能与人 C 型凝集素特异性结合的结合分子可用于诊断、预防和/或治疗肿瘤性紊乱和疾病。
• System for RF-induced hyperthermia
  申请人：Therm Med LLC

  公开号：EP2345453A2

  公开（公告）日：2011-07-20

  An RF transmitter and receiver system for inducing hyperthermia to kill or damage target cells in at least a portion of a target area, e.g. a tumour or a portion of a tumour or targeted cancerous cells, is provided. Targeted RF absorption enhancers, e.g. antibodies bound to RF absorbing particles, are introduced into a patient. These targeted RF absorption enhancers will target certain cells in the target areas and enhance the effect of a hyperthermia generating RF signal directed toward the target area. The targeted RF absorption enhancers may, in a manner of speaking, add one or more RF absorption frequencies to cells in the target area, which will permit a hyperthermia generating RF signal at that frequency or frequencies to heat the targeted cells.

  提供了一种射频发射器和接收器系统，用于诱导热疗，以杀死或破坏目标区域至少一部分的靶细胞，例如肿瘤或肿瘤的一部分或靶向癌细胞。将靶向射频吸收增强剂，例如与射频吸收粒子结合的抗体，导入患者体内。这些靶向射频吸收增强剂将靶向目标区域的某些细胞，并增强针对目标区域的热疗产生射频信号的效果。可以说，靶向射频吸收增强剂可以为目标区域的细胞增加一个或多个射频吸收频率，从而使产生热疗的射频信号以该频率加热目标细胞。
• Systems and methods for RF-induced hyperthermia using biological cells and nanoparticles as RF enhancer carriers
  申请人：Kanzius John

  公开号：US20050251234A1

  公开（公告）日：2005-11-10

  A method of inducing hyperthermia in at least a portion of a target area—e.g., a tumor or a portion of a tumor or targeted cancerous cells—is provided. Targeted RF absorption enhancers, e.g., tumor infiltrating lymphocytes (TILs) containing RF absorbing particles, are introduced into a patient. These targeted RF absorption enhancers will target certain cells in the target areas and enhance the effect of a hyperthermia generating RF signal directed toward the target area. The targeted RF absorption enhancers may, in a manner of speaking, add one or more RF absorption frequencies to cells in the target area, which will permit a hyperthermia generating RF signal at that frequency or frequencies to heat the targeted cells.

  提供了一种在目标区域的至少一部分--例如肿瘤或肿瘤的一部分或靶向癌细胞--诱导热疗的方法。将靶向射频吸收增强剂，例如含有射频吸收颗粒的肿瘤浸润淋巴细胞（TILs）导入患者体内。这些靶向射频吸收增强剂将靶向目标区域的某些细胞，并增强针对目标区域的热疗产生射频信号的效果。可以说，靶向射频吸收增强剂可以为目标区域的细胞增加一个或多个射频吸收频率，从而使产生热疗的射频信号以该频率加热目标细胞。
• Systems and methods for combined RF-induced hyperthermia and radioimmunotherapy
  申请人：Kanzius John

  公开号：US20050273143A1

  公开（公告）日：2005-12-08

  A combined radiotherapy and hyperthermia therapy is provided, including inducing hyperthermia in at least a portion of a target area—e.g., a tumor or a portion of a tumor or targeted cancerous cells—is provided. Biomolecules labeled with at least one radionuclide suitable for radiotherapy are provided and introduced into a patient; targeted RF absorption enhancers are provided and introduced into a patient; and a hyperthermia generating RF signal is directed via toward the target cells, thereby warming the radionuclide-labeled biomolecules and targeted RF absorption enhancers bound to target cells. The targeted RF absorption enhancers may, in a manner of speaking, add one or more RF absorption frequencies to cells in the target area, which will permit a hyperthermia generating RF signal at that frequency or frequencies to heat the targeted cells. Biomolecules labeled with at least one radionuclide suitable for radiotherapy may be used for both radiotherapy and as RF absorption enhancers for the hyperthermia generating RF signal.

  提供了一种放疗和热疗联合疗法，包括在至少一部分靶区--例如肿瘤或肿瘤的一部分或靶向癌细胞--诱导热疗。提供用至少一种适合放疗的放射性核素标记的生物大分子，并将其导入患者体内；提供靶向射频吸收增强剂，并将其导入患者体内；产生热疗的射频信号通过靶细胞定向，从而加热与靶细胞结合的放射性核素标记的生物大分子和靶向射频吸收增强剂。可以说，靶向射频吸收增强剂可为靶区细胞增加一个或多个射频吸收频率，从而使产生热疗的射频信号以该频率加热靶细胞。标记有至少一种适用于放射治疗的放射性核素的生物分子既可用于放射治疗，也可用作产生热疗射频信号的射频吸收增强剂。